2.Research progress on ferroptosis in the treatment of bladder cancer
Jingping QIU ; Lugang ZHU ; Yuanwei CHEN ; Minghong ZHOU ; Yuwan ZHAO ; Jianjun LIU
Journal of Modern Urology 2024;29(9):830-835
Ferroptosis is a new programmed cell death dependent on iron ions.Ferroptosis can be induced by endogenous or exogenous pathways, and cells exhibit specific cell morphological signs and are regulated by a variety of molecular mechanisms.In recent years, more and more studies have shown that ferroptosis plays an important role in the treatment of cancer.This article summarizes the mechanism of ferroptosis in bladder cancer and the regulation of cancer cells, as well as the role of ferroptosis-related factors, non-coding RNA regulation, N6-methyladenosine (m6A), amino acid metabolism and autophagy dependent ferroptosis in the growth and proliferation of bladder cancer, with a view to provide new strategies for the treatment of bladder cancer.