Verrucous carcinoma is a form of low grade squamous cell carcinoma that is characterized grossly by its exophytic and wart-like appearance. We experienced a case of verrucous carcinoma in a 63-year-old female patient who presented with pyelonephritis caused by staghorn calculi. Abdominal CT scan showed a renal pelvic mass and nephrectomy was done. Histologic examination showed extensive keratinizing squamous metaplasia of pelvic urothelium with an area of verrucous acanthosis. To our knowledge, this is the second case of verrucous carcinoma of renal pelvis that has been reported in literature. We describe a case and review the literature concerning verrucous carcinoma.
Calculi ; Carcinoma, Squamous Cell ; Carcinoma, Verrucous* ; Female ; Humans ; Kidney Pelvis* ; Metaplasia ; Middle Aged ; Nephrectomy ; Pyelonephritis ; Tomography, X-Ray Computed ; Urothelium

Intrascrotal lymphangioma is a rare benign lesion of uncertain etiology. A 2-year-old male and a 3-year-old male presented with painful swelling of the right scrotum. After sonographic examination of scrotums, both cases were explored and found to have cystic scrotal masses separated from testes and epididymies. Histopathologic study of the resected specimens confirmed intrascrotal lymphangiomas.
Child, Preschool ; Humans ; Lymphangioma* ; Male ; Scrotum ; Testis ; Ultrasonography

OBJECTIVES: To investigate the possibility of utilizing DNA adduct as a carcinogenic biological marker for workers exposed to chromium, and the effect of chromium exposure on the formation of urinary 8-hydroxydeoxyguanosine(8-OH-dG) was also evaluated. METHODS: The chromium concentrations of venous blood and urine were measured in 20 chromium exposed workers(exposure group) and in 11 chromium workers(control group) who were not exposed. The concentration of 8-OH-dG in their urine was determined using high performance liquid chromatography with electrochemical detection. RESULTS: The blood chromium concentration was significantly higher in the exposure group ( 0.46+/-0.18 microgram/100 ml) than in control group(0.27+/-0.15 microgram/100 ml), but the urinary chromium concentration was not significantly higher in the exposure group. The urinary 8-OH-dG was higher in the exposure group(1.71+/-1.82 micromol/mol creatinine) than that in the control group(0.45+/-0.46 micromol/mol creatinine) and was significantly correlated with the blood chromium concentration(r=0.49). Results of multiple regression analysis revealed that the level of urinary 8-OH-dG depended upon the level of the blood chromium conc entration ( r2= 0.21). CONCLUSIONS: Urinary 8-OH-dG was significantly related to chromium exposure and this finding suggests the possibility that urinary 8-OH-dG could be used as a biological index of chromium induced DNA damage.
Biological Markers ; Chromatography, Liquid ; Chromium* ; DNA ; DNA Damage

PURPOSE: Few studies have examined acute prostatitis in Korea. To initiate the investigation of this topic, a multi-center retrospective analysis of acute prostatitis was conducted. MATERIALS AND METHODS: The clinical records of 335 patients from 13 hospitals, diagnosed with acute prostatitis, between January of 1994 and October of 2004, were reviewed. For each patient, the urine culture, changes in the PSA (prostate-specific antigen) value and the prostate volume, the incidence of prostate abscess, the use of antibiotics, and whether the disease went into remission or progressed to chronic prostatitis were analyzed. RESULTS: The mean age of the patients, time from the onset of symptom to admission and number of days of admitted were 54.9+/-15.1 (16-85) years, 2.4+/-3.4 (16-85) days and 7.5+/-3.9 (1-25) days, respectively. The chief symptoms of the patients were high fever, dysuria and urinary frequency. Routine urinalysis found pyuria in 82% and hematuria in 70% of patients. The causative organisms of 43.0% of the patients were cultured, with the chief organisms found to be E. coli (67%) and P. aeruginosa (13%), et al. The mean PSA and prostate volume on initial diagnosis were 24.6+/-30.2ng/ml and 45.8 +/-17.4ml, respectively, and a prostate abscess was found in 4 patients (3.1%). The antibiotics injected during patient admission were: cephalosporin family (68%), aminoglycosides (70%) and quinolone family (43%). An additional alpha blocker was used in 49% of cases. Oral quinolone (91%), cephalosporin (9%) and alpha blocker (44%) were prescribed for a mean 32.5 (2-180) days after discharge. 259 (77%) of the patients were available for follow-up. Of these, 21% took antibiotics over an 8 week treatment period, and 8% over a 12 week period. The disappearance of pyuria after treatment was observed in a mean of 13 days after the end of treatment. After 13 weeks of treatment, 11 (50%) of the 22 patients who received prostate massage (4.2% of all follow up patients) were found to have chronic prostatitis. The mean PSA and prostate volume declined during follow up, to 6.13+/-10.38ng/ml and 37.5+/-13.5ml, respectively. CONCLUSIONS: In our study, the most common chief symptom of acute prostatitis was a high fever, with the most common causative organism being E. coli. Patients were admitted for approximately one week, and treated with antibiotic for about one month, after which time PSA elevation was observed in 80% of patients. Although all acute prostatitis patients were treated with proper antibiotics, progression to chronic prostatitis was observed in 4.2% of patients.
Abscess ; Aminoglycosides ; Anti-Bacterial Agents ; Diagnosis ; Dysuria ; Fever ; Follow-Up Studies ; Hematuria ; Humans ; Incidence ; Korea ; Massage ; Patient Admission ; Prostate ; Prostate-Specific Antigen ; Prostatitis* ; Pyuria ; Retrospective Studies ; Urinalysis

PURPOSE: To compare the variable inflammatory parameters of acute pyelonephritis patients treated with inpatient therapy at 13 hospitals, according to the age and gender distributions. MATERIALS AND MATHODS: A total of 3,544 medical records of patients with confirmed acute pyelonephritis, and admitted to hospital between January 2000 and December 2005, were retrospectively analyzed. RESULTS: The mean age of the patients was 43.2+/-16.2 years old, with a male:female ratio of 1 : 5.1. The average duration of hospital admission was 7.9+/-5.3 days. Underlying diseases were found in 23.0% (749/3,252 patient), largely due to diabetes (35.1%). Radiological abnormal findings were found in 13.7%. The leukocyte count, ratio of segmented form, erythrocyte sedimentation rate (ESR), c-reactive protein, pyuria, positive blood culture, positive urine culture were 11,014+/-5,778/mm(3), 74.8+/-14.5%, 44.0+/-32.0 mm/hr, 12.4+/-9.3mg/dl, 83.9%, 10.5% and 46.7%, respectively. E. coli grow in 79% of the urine culture positive patients. In a comparison of 3 age groups (<40 years, 40-60 years, >61 years), the elderly patients had a greater number of underlying diseases and more pathogens in cultured blood. When divided into males and females, the elderly male patients had more pathogen in cultured urine, but contrary to the male patients, the elderly female patients had elevated leukocyte count and erythrocyte sedimentation rate. Also, the old patient group had more resistance to ampicillin when they had E. coli as the uropathogen (p=0.021). Patients with higher ESR required longer hospital admission periods. CONCLUSIONS: It was found that variable clinical parameters of acute pyelonephritis patients treated with inpatient therapy differed according to both gender and age group in Korea. Therefore, these factors should be taken into account in the treatment plan.
Aged ; Ampicillin ; Blood Sedimentation ; C-Reactive Protein ; Female ; Humans ; Inpatients ; Korea ; Leukocyte Count ; Male ; Medical Records ; Pyelonephritis* ; Pyuria ; Retrospective Studies