Objective To study effect of refined nursing management in the treatment of asthma in children with acute bronchitis and its effect on lung function,white blood cell count and Creactive protein.Methods A total of 128 children with bronchitis admitted in our hospital were randomly divided into study group and control group,with 64 cases in each group.The patients in the control group were treated with traditional care,and the patients in the study group implemented refined nursing management.The symptom disappearing time,oxygen saturation,pulmonary function indicators [forced expiratory volume in one second (FEV1),forced vital capacity (FVC),peak expiratory flow rate (PEFR)],white blood cell count,and C-reactive protein were observed and compared in two groups.Results The symptoms disappeared time such as cough and asthma in the study group was significantly shorter,and oxygen saturation was higher than that in the control group (P ＜ 0.05).Before nursing intervention,levels of FEV1,FVC and PEFR between the two groups had no significant differences (P ＞ 0.05),and were significantly improved after nursing in both groups,and the study group improved more than that in the control group (P ＜ 0.05).After nursing intervention,the C-reactive protein and white blood cell counts in both groups were lower than before nursing,and the study group was lower than the control group,the difference was statistically significant (P ＜0.05).Conclusion Refined nursing management in children with acute bronchitis can significantly reduce asthma,cough symptoms,shorten treatment and hospitalization time,improve treatment compliance and lung function,so it is worthy of further promotion.

Objective To study effect of refined nursing management in the treatment of asthma in children with acute bronchitis and its effect on lung function,white blood cell count and Creactive protein.Methods A total of 128 children with bronchitis admitted in our hospital were randomly divided into study group and control group,with 64 cases in each group.The patients in the control group were treated with traditional care,and the patients in the study group implemented refined nursing management.The symptom disappearing time,oxygen saturation,pulmonary function indicators [forced expiratory volume in one second (FEV1),forced vital capacity (FVC),peak expiratory flow rate (PEFR)],white blood cell count,and C-reactive protein were observed and compared in two groups.Results The symptoms disappeared time such as cough and asthma in the study group was significantly shorter,and oxygen saturation was higher than that in the control group (P ＜ 0.05).Before nursing intervention,levels of FEV1,FVC and PEFR between the two groups had no significant differences (P ＞ 0.05),and were significantly improved after nursing in both groups,and the study group improved more than that in the control group (P ＜ 0.05).After nursing intervention,the C-reactive protein and white blood cell counts in both groups were lower than before nursing,and the study group was lower than the control group,the difference was statistically significant (P ＜0.05).Conclusion Refined nursing management in children with acute bronchitis can significantly reduce asthma,cough symptoms,shorten treatment and hospitalization time,improve treatment compliance and lung function,so it is worthy of further promotion.

Sleep deprivation (SD) has a profound impact on the central nervous system, resulting in an array of mood disorders, including depression and anxiety. Despite this, the dynamic alterations in neuronal activity during sleep deprivation have not been extensively investigated. While some researchers propose that sleep deprivation diminishes neuronal activity, thereby leading to depression. Others argue that short-term sleep deprivation enhances neuronal activity and dendritic spine density, potentially yielding antidepressant effects. In this study, a two-photon microscope was utilized to examine the calcium transients of anterior cingulate cortex (ACC) neurons in awake SD mice in vivo at 24-hour intervals. It was observed that SD reduced the frequency and amplitude of Ca2+ transients while increasing the proportions of inactive neurons. Following the cessation of sleep deprivation, neuronal calcium transients demonstrated a gradual recovery. Moreover, whole-cell patch-clamp recordings revealed a significant decrease in the frequency of spontaneous excitatory post-synaptic current (sEPSC) after SD. The investigation also assessed several oxidative stress parameters, finding that sleep deprivation substantially elevated the level of malondialdehyde (MDA), while simultaneously decreasing the expression of Nuclear Factor erythroid 2-Related Factor 2 (Nrf2) and activities of Superoxide dismutase (SOD) in the ACC. Importantly, the administration of gallic acid (GA) notably mitigated the decline of calcium transients in ACC neurons. GA was also shown to alleviate oxidative stress in the brain and improve cognitive impairment caused by sleep deprivation. These findings indicate that the calcium transients of ACC neurons experience a continuous decline during sleep deprivation, a process that is reversible. GA may serve as a potential candidate agent for the prevention and treatment of cognitive impairment induced by sleep deprivation.

Objective:To study the value of myocardial perfusion imaging (MPI) and coronary flow reserve (CFR) combined with coronary artery calcium score (CACS) in the diagnosis of obstructive coronary artery disease (CAD).Methods:From January 2019 to December 2020, 96 confirmed or suspective CAD patients (65 males, 31 females; age: 30-81 years) who completed rest/stress MPI, CFR and CACS defection in Fuwai Central China Cardiovascular Hospital were retrospectively analyzed. Coronary angiography (CAG) was used as the diagnostic standard to calculate the sensitivity and accuracy of MPI, CFR and MPI/CFR combined with CACS in the diagnosis of CAD. The χ2 test was used to compare the diagnostic efficiency of different methods. Results:The diagnostic sensitivity of MPI was 76.06%(54/71), and the accuracy was 75.00%(72/96), while the sensitivity increased to 97.18%(69/71; χ2=13.67, P<0.001) and the accuracy increased to 87.50%(84/96; χ2=4.92, P=0.020) with significant differences after combined with CACS. The sensitivity and accuracy of CFR were 91.55%(65/71)and 87.50%(84/96), which increased to 97.18%(69/71; χ2=2.12, P=0.137) and 89.58%(86/96; χ2=0.21, P=0.411) with no significant differences after combined with CACS. The sensitivity of MPI in the diagnosis of three-vessel CAD was 70.00%(21/30), which increased to 100%(30/30; χ2=7.75, P=0.004) after combined with CACS; while the sensitivity of MPI combined with CACS in the diagnosis of single-vessel and double-vessel CAD were not significantly improved ( χ2 values: 3.29, 1.51, P values: 0.114, 0.416). Conclusion:The combination of MPI and CACS can significantly improve the diagnostic efficiency of CAD, contributed by the improvement of the diagnostic sensitivity in three-vessel disease; whereas the diagnostic efficiency of CFR for CAD is not significantly improved after combined with CACS.