1.Hie Changes of Plasma Atrial Natriuretic Polypeptied in Children with Congenital Heart Disease and Their Significance
Zuo LUAN ; Zhijia ZHOU ; Zemin MA
Academic Journal of Second Military Medical University 1981;0(04):-
The levels of plasma immunoreactive atrial natriuretic polypeptide (ir-ANP) were determined by radioimmunoassay in 59 children with congenital heart disease (CHD). It was showed that the ir-ANP levels of the patients with left to right shunt were higher than those of control (P0.05). The iir-ANP levels of patients with HYHA II degree were increased significantly (P
2.Significance of Changes of Tumor Necrosis Factor-? and Interleukin-6 Level in Children with Acute Viral Myocarditis
yan, LI ; wen-ping, ZHOU ; bin, LUAN
Journal of Applied Clinical Pediatrics 2006;0(13):-
Objective To explore the clinical significance and changes of tumor necrosis factor-?(TNF-?)and interleukin-6(IL-6)level in children with acute viral myocarditis(AVM).Methods TNF-? and IL-6 level in serum from 53 AVM children and 20 healthy children were measured by radio-immunoassay and enzyme-linked immunosorbent assay(ELISA).The relation between the levels of TNF-? and IL-6 in serum with the occurrence and development in acute viral myocarditis was analyzed.Results Thirty-two were males and 21 females in the 53 AVM children.The ages ranged from 3-11 years old.There were 12 males and 8 females in control group.The serum level of TNF-? and IL-6 were(526.7?32.9),(3.23?0.53)mg/L in AVM group and(383.1?27.5),(1.63?0.22)mg/L in control group.There were significant difference between the 2 groups(Pa
3.Temporoparietooccipital and parietooccipital disconnection in patients with intractable epilepsy
Yuguang Guan ; Guoming Luan ; Jian Zhou
Neurology Asia 2013;18(s1):57-59
Objective: To assess the surgical techniques and surgical outcomes of temporoparietooccipital and
parietooccipital disconnection. Methods: The authors conducted a retrospective review of clinical,
neuropsychological, EEG, imaging data in 16 patients with intractable epilepsy who underwent
temporoparietooccipital and parietooccipital disconnection between April 2008 and October 2011.
Of the 16 cases, 12 were males and 4 were females. The age of seizure onset was from 0.1 to 27
years (average 6.6) and disease duration of 0.1 to 18 years (average 7.5). The surgery was performed
between the age of 3 and 37 years (average 14.1). Nine patients underwent temporoparietooccipital
disconnection, 5 patients parietooccipital disconnection and 2 patient parietooccipital disconnection
and temporal lobotomy. Results: After a mean follow-up of 1.6 years (range 0.5–3.9 years), 13 patients
(81%) were seizure free, 1 patient had Engel Class II seizure outcome and 2 patient had Engel class
III outcome. Two patients exhibited severe brain swelling and one patients had second resective
operation with good recovery. None of the patients developed new motor defi cits postoperatively and
there was no mortality.
Conclusion: Temporoparietooccipital and parietooccipital is a safety and effective epilepsy surgery
procedure for patients with epileptic zone localization to the posterior quadrant on one side. The results
of surgical disconnection for posterior quadrantic epilepsy have yielded excellent seizure outcomes
in 81% of the patients, with no mortality or major morbidity.
4.Determination of the Related Substances in Azithromycin Tablet by HPLC-Electrochemical Detector
Jie LUAN ; Guoqing ZHOU ; Haixia WANG
China Pharmacy 2007;0(25):-
OBJECTIVE: To determine the content of the related substances in azithromycin tablet by HPLC-electrochemical detector.METHODS: The column was Gamma ARP-1/P.The mobile phase consisted of 0.014 mol?L-1 dipotassium hydrogen phosphate/0.020 mol?L-1 sodium hydroxide(pH was adjusted to 11 by phosphoric acid and sodium hydroxide)-acetonitrile(71∶29) at a flow rate of 0.7 mL?min-1.The column temperature was 40 ℃.The injection volume was 50 ?L.Glass carbon working electrode was set at +900 mV.RESULTS: The linear ranges of erythromycin peroxide,deoxyazithromycin,azithromycin impurity A,and N-demethlation azithromycin were 0.15~1.80 ?g(r=0.999),0.09~1.08 ?g(r=0.999),0.23~2.76 ?g(r=0.998) and 0.30~3.60 ?g(r=0.998),respectively.The average recoveries were 98.9%(RSD=1.1%),94.6%(RSD=5.4%),103.4%(RSD=3.4%) and 96.2%(RSD=4.3%),respectively.The contents of the related substances were all below 0.7%.CONCLUSION: The established method is reproducible,sensitive and reliable,and applicable for the detection of the related substances in azithromycin tablets.
5.Discussions of medical disputes on birth defects of newborns
Liangyu WEI ; Xiaolin LUAN ; Pengcheng SUN ; Tianhong REN ; Wenbo ZHOU
Chinese Journal of Hospital Administration 2014;30(6):444-446
A variety of views and approaches were found in the appraisal and judgments of the people's courts in various provinces and cities,on medical disputes involving absence of a hand or foot of newborns,which result in different or event contradictory court decisions.This study made an analysis of the characteristics,nature,and classification of such cases as well as countermeasures of medical institutions,with recommendations on rational and appropriate handling of such cases,for the purposes of legitimate rights maintenance of both doctors and patients,and promotion of mutual understanding between the two parities,and establishment of a harmonious doctor-patient relationship.
6.Relation between sex role and social anxiety and the mediating effect of self-acceptance study in college students
Yasong LUAN ; Jianqin CAO ; Yuqiu ZHOU ; Jun YANG ; Yang LI
Chinese Mental Health Journal 2015;(4):311-315
Objective:To explore the relationship between social anxiety and sex role in college students,and to analyze the mediating effect of self-acceptance between them.Methods:Data came from a sample of 2000 col-lege students in Daqing,who were selected by stratified random cluster sampling method according to the constitu-ent ratio of the college students.We used the Interaction Anxiety Scale (IAS)to assess subjective experience of so-cial anxiety,Bem Sex-Role Inventory (BSRI)to evaluate sex-role classification and Self-Acceptance Questionnaire (SAQ)to measure characteristics of self-acceptance.Results:In the college,the distribution of sex-role classifica-tion were androgynous 656 (34.9%),undifferentiated 650 (34.6%),masculine 287 (15.3%),feminine 284 (15.1%).The differences of gender in scores of IAS and SAQ were not significant (Ps >0.05),but there were significant differences among sex roles (P <0.001).IAS scores of feminine were significantly higher than the oth-ers,and the scores of androgyny and masculine were both lower than the other two significantly.SAQ scores offeminine and undifferentiated were both significantly lower than the other two respectively (Ps <0.05).By Boot-strap test,masculine,undifferentiated and feminine (vs.androgynous)could mediate IAS through self-acceptance, the mediating effects were 0.76 (95%CI:0.09 -1.42),4.14 (95%CI:3.43 -4.93),and 4.03 (95%CI:3.47 -4.64) respectively.There was a mediating effect.Both undifferentiated (vs.androgynous ) and feminine (vs.androgynous)directly influenced IAS significantly (Ps <0.05).Conclusion:Social anxiety may be related to sex role but not gender,social anxiety level of feminine students is higher,the sex-role types could influence social anxiety through self-concept indirectly.
7.The prevalence rate and growth environmental factors of social anxiety disorder among Daqing college students
Yasong LUAN ; Jianqin CAO ; Yuqiu ZHOU ; Jun YANG ; Jinwei YANG
Chinese Journal of Behavioral Medicine and Brain Science 2014;23(9):793-796
Objective To know the point prevalence rate of social anxiety disorder(SAD) in Daqing University,and explore the influence factors about growth environment.Methods Data came from a large representative sample of 1878 university students,who were selected by stratified random cluster sampling methods according to the constituent ratio of students.They finished general situation questionnaire,interaction anxiety scale (IAS),adolescent self-rating life events check list(ASLEC),Egma Minnen av Bardndosnauppforstran(EMBU) respectively.According to the score of IAS,they were divided into 3 groups of high,mid and low.And then all of the high group,the 50% and 10% randomly of the mid and the low group respectively accepted the face-to-face interviews with 6 trained psychiatrists referred to SCID-I/P.Results Among 1878 Daqing university students,191 of them were diagnosed as SAD,with a point prevalence rate of 8.89%.The rate of rural students was higher than that in urban students(12.3% vs.8.5%,x2 =7.966,P=0.017),and the rate of non-only child was higher than only child (12.0% vs.9.1%,x2 =4.055,P=0.044).There were significant differences between SAD and No-SAD on many factors of ASLEC and EMBU.Logistic regression analysis showed that study stress in ASLEC(B=0.206),father's warm (B =-0.070),father's overprotection (B =0.286),mother's punishment (B =0.159),only child or not (B =-0.685) entered into regression equation.Conclusion The point prevalence rate of SAD in Daqing university students is 8.89% and influenced by several growth environmental factors.Only child or not,father's warm,father's overprotection,mother's punishment,study stress in ASLEC can forecast SAD occurrence.
8.Treatment of 32 Cases of Meniere Disease with Acupuncture
Yufen LUAN ; Xiangcang ZHOU ; Zhaoxia GONG ; Kun ZHANG
Journal of Acupuncture and Tuina Science 2008;6(2):104-105
Thirty-two patients with Meniere disease were treated by acupuncture therapy,Baihui(GV 20),Fengfu(GV 16),bilateral Fengchi(GB 20),Shenshu(BL 23),Taixi(KI 3),and Xuanzhong(GB 39)were selected.Of the 32 cases,8 cases was totally under control,12 cases were generally under control,9 cases were partly under control and 3 cases were out of control,the totaI effective rate was 90.6%.
9.Clinical effect and pathogenesis of tiopronin in treating acute pancreatitis complicated with liver damages
Chunyan LUAN ; Zhigang LIU ; Hongmei ZHOU ; Yinhua ZHANG ; Cunxin ZHAO
Chinese Journal of Postgraduates of Medicine 2010;33(25):6-8
Objective To investigate the clinical effect and pathogenesis of tiopronin in treating acute pancreatitis complicated with liver damages. Methods Eighty-one patients with acute pancreatitis complicated with liver damages were randomly divided into two groups. The control group (40 cases) received routine treatment, and the treatment group (41 cases ) received routine treatment and tiopronin. The liver function, pancreatic enzyme indexes and C-reactive protein (CRP), the length of hospital stay was recorded. Results After 8 days' treatment, the liver function improved, and the levels of pancreatic enzyme indexes and CRP were decreased significanfly in both groups, and these changes were more obvious in treatment group (P <0.05). The length of hospital stay of mild acute pancreatitis in treatment group was significantly shorter than that in control group [ (8.6 ± 2.7 ) d vs. ( 13.8 ± 3.5 ) d ] (P < 0.05 ). Conclusions Tiopronin has beneficial effects in treating acute pancreatitis complicated with liver damages,and it has a therapeutic effect in acute pancreatitis at the same time. The mechanism may be related with the inhibition of inflammatory mediators, oxygen free radicals scavenging and other effects.
10.A phase Ⅱ prospective study on raltitrexed combined with concurrent radiotherapy for elderly esophageal carcinoma
Wei ZHANG ; Luan GUAN ; Haitao YIN ; Chong ZHOU ; Chengjun WU
Journal of International Oncology 2017;44(7):504-507
Objective To evaluate the clinical effects and adverse reaction of raltitrexed combined with radiation for esophageal carcinoma in elderly patients.Methods Sixty patients were randomly divided into two groups by the envelope method, 30 patients in experimental group received raltitrexed combined with radiotherapy and 30 patients in control group received radiotherapy only.Patients in both groups received conventional radiotherapy with a total dose of 56-60 Gy/28-30 F.In experimental group, raltitrexed 2.6 mg/m2 was administered concurrently with the radiotherapy on d1 and d22.Two cycles of concurrent chemotherapy were administered during radiotherapy.The short-term effects, survival times and adverse reactions of the two groups were compared.Results The total effective rates of experimental group and control group were 93.3% and 73.3%, respectively, and there was statistically significant difference between the two groups (χ2=4.320, P=0.038).The median survival times of experimental group and control group was 24.0 months and 12.0 months, respectively, and there was statistically significant difference by Log-rank test (χ2=6.048, P=0.014).The major adverse reactions of grade 3-4 in experimental group and control group were radiation-induced esophagitis (10.0% vs.3.3%;χ2=0.268, P=0.605), leukopenia (13.3% vs.10.0%;χ2=0.000, P=1.000), thrombocytopenia (3.3% vs.0;P=1.000), nausea and vomiting (6.7% vs.0;χ2=0.517, P=0.472), and the differences were not statistically significant.Conclusion Raltitrexed combined with radiotherapy can enhance the short-term effect and prolong the survival time for the elderly esophageal carcinoma patients, and the adverse reactions are mild.It is worthy of further clinical study.