Diffuse large B cell lymphoma (DLBCL) is one of the most common non-Hodgkin lymphoma (NHL).Since the appearance of rituximab,the most common first-line therapy is rituximab in combination with chemotherapy.About 70 percent of patients could achieve complete remission (CR) and be cured finally.But one third of patients could not reach CR after frontline treatment or relapse early,especially the elder patients or high risk ones.In the 56th American Society of Hematology (ASH) annual meeting,a plenty of treatments focusing on these patients brought encouraging results,which makes it possible to further improve the CR rate.The progresses in relapse/refractory,high risk and special site DLBCL will be summarized in this paper based on the reports in the 56th ASH annual meeting.

Mantle cell lymphoma (MCL), being a kind of aggressive non-Hodgkin ' s lymphoma (NHL), accounts for 6 % - 8 % of NHL in adults which is characterized by malignant B cell infiltration of lymph node, gastrointestinal tract and bone marrow. MCL commonly responds to initial therapy but inevitably occurs relapse and drug resistance. The study on MCL in the 58th American Society of Hematology Annual Meeting has covered many aspects such as basic research, clinical treatment and new drug research. The development of novel mouse model and the exploration of signaling pathways provide a basis for the improvement of MCL pathogenesis and new drug research. VcR-CVAD, VCR and some other chemotherapy regimens designed for different patients have showed satisfactory results. New drugs such as inhibitors of CDK, PI3K and bcl-2 in initial clinical trials are also promising. IACS-010759 and other small molecules provide new directions for the treatment of MCL.

Objective:To evaluate the staining of different resin artificial teeth treated by different coloring agents.Methods:1 6 teeth of each brand of Endura Anterio,Heraeus's three color synthetic resin teeth,synthetic resin teeth,Efucera-A,KaiFeng synthetic resin teeth were respectively made into test specimens.A surface roughness tester was used to measure Ra along 3 tracks on each sur-face.The specimens of the same brand were respectively immersed into coffee,tea and vinegar as the test groups and distilled water as a control for 4 weeks.The initial and further color of each specimen was measured using a colorimeter.The CIE L* a* b* values were recorded and color differences (ΔE)after immersion were calculated.Data were statistically analyzed by ANOVA.Results:The color stability of the specimens in coffee and tea was significantly affected by the coloring agents(P <0.05),the higher ΔE was ob-served in coffee than in tea(P <0.05).There were no statistically evident color change in water and in vinegar(P >0.05).The ΔE values in the same coloring agent were as follows:Efucera-A,Heraeus's three color synthetic resin teeth,Endura Anterio,synthetic resin teeth and KaiFeng synthetic resin teeth (P <0.05).Conclusion:Extrinsic pigment can make resin artificial teeth stained,and the staining susceptibility of five resin artificial teeth is different.

Objective To explore fMRI data with independent component analysis (ICA) in order to investigate effects of transcutaneous electrical acupoint stimulation (TEAS) on brain function. Methods The experiment was performed on a whole-body 1.5 T GE Signa Excite MRI scanner with which the brain oxygenation level dependent (BOLD)/EPI images were acquired from a female traumatic brain injury patient. A block designed protocol was used. Both durations of rest and TEAS were 30 seconds. The data processing was performed with GIFT, Statistical Parametric Mapping 5 (SPM5) and MRIcro. Results from ICA and SPM were compared. Results Extended Infomax algorithm provided by GIFT found thirteen independent components (ICs), each of which contained a spatial map and a corresponding time course. The spatial maps associated with task-related ICs resembled the activation maps from SPM5 but were not totally identical. In addition, the time courses of these ICs differed from the shape of canonical HRF model used by SPM. Conclusion ICA is a good choice to investigate data and obtain prior knowledge before using model-based methods such as SPM.

Objective To discuss the clinical application of MSCT-guided BARD gun biopsy in diagnosing pulmonary lesions. Methods Under MSCT-guidance percutaneous transthoracic biopsy of lung with BARD gun was performed in 68 patients with pulmonary lesions. Results All the procedures were well performed with the technical successful rate of 100%. The final diagnosis was based on the pathological findings or clinical follow-up observation. The accuracy of the qualitative diagnosis was 94.1%. Of 68 patients, squamous cell carcinoma was found in 30, adenocarcinoma in 21, metastases in 7, inflammatory pseudotumor in 3, lung abscess in 2, and tuberculosis in one. The false-negative rate in making diagnosis was 5.9%. The complication occurrence was 8.8%. Conclusion BARD gun has the advantage of making coaxial- multipoint biopsy. With the help of MSCT-guidance and the full use of the operating advantage of BARD gun, this technique is safe and reliable, with higher accuracy and less complications.

Objective To probe into the clinical features and pathological change of GM 2 gangliosidosis. Methods The clinical manifestations of 2 patients with late onset GM 2 gangliosidosis were reported, a biopsy of the right frontal lobe was performed for each case.Results The clinical manifestations of the late onset GM 2 gangliosidosis were nonspecific, the ballooned neurons with cytoplasmic deposits were found under the light microscopy.The deposits were membranous cytoplasmic bodies(MCB) together with zebra bodies.Conclusion The result suggested that light microscopy with electron microscopy in taking brain biopsy was very important for the diagnosis of GM 2 gangliosidosis.

Objective To guide the treatment of acute exacerbation of chronic obstructive puhnonary diseases (AECO- PD) through studing the principally related factors of AECOPD.Methods 190 AECOPD patients were investigated through retrospective study.First,we studied the thirty-two possible factors with single-factor analysis,then procee- ded to perform multiple-factor analysis with Logistic regression among the factors which P value was below 0.2 in single -factor analysis,and analyzed the principally related factors with two-factor correlation.Results According to Mul- tiple-factor analysis with Logistic regression analysis,there were eight factors that showed significance,which were us- age of respiratory excitant,LBC,usage of antioxidant,heart failure,Cr,selection of antibiotics respectively,WBC and Hb.Correlative analysis of the principally related factors showed no correlation between WBC and LBC.Conclusion The principally related factors of AECOPD prognosis were their recited in results.

Objective To observe the clinical therapeutic effect of danshenfenzhen and nutritional support in treating congestive heart failure accompanied with malnutrition on the basis of common treatment.Methods 42 cas- es of congestive heart failure accompanied with malnutrition were randomly divided into 2 groups:test group 21 cases (danshenfenzhen and nutritional support) and control group 21 cases(free diet),in the test group intravenous drip danshenfenzhen and vein nutrition were given if the internal nutrition can not provide enough energy on the basis of count of energy consumption,the serum albumin,total blood lymph cells and body weight were measured.Results After 14 days' treatment in the test group,the serum albumin,body weight and the total lymph cell increased signifi- cantly while in the control group,the serum albumin,body weight and the total lymph cells decreased significantly. Conclusion Intravenous drip danshenfenzhen and nutritional support can improve nutritional status and cardiac function of patients with congestive heart failure accompanied with malnutrition.

Objective To investigate the value of virtual colonoscopy in the diagnosis of malignant and benign lesions in the colon. Methods CT colography was performed in 37 patients. Patients included 20 cases colon polyps, 6 cases colon cancer, 4 cases diverticulum, 5 cases ulcerative colitis and 2 cases other benign lesions. The colon lesions were evaluated with 2D and 3D images, depending on individual software. Results were compared with colonoscopy for each case. Results 17 cases colon polyps, 6 cases colon cancer, 4 cases diverticulum, 2 cases ulcerative colitis were detected by CTC. Conclusion CT virtual colography is a promising technique for the detection of colorectal lesions. This procedure is minimal invasive and fast, causes mild patient discomfort.

Background and purpose: With the development of therapy equipments and technology, the treatment for nasopharyngeal carcinoma(NPC) has entered into the era of precision radiotherapy, and setup errors have become a very important factor affecting treatment effects. The purpose of this study was to analyze the set-up errors detected by the kilovoltage cone beam CT(EPID) and the megavoltage electronic portal imaging device(CBCT) using 2 kinds of different immobilization techniques (pillow+head neck shoulder mask and vacuum bag+head neck shoulder mask) for NPC patients. Methods:A total number of 40 NPC patients were randomly assigned into 2 groups (pillow+head neck shoulder mask group and vacuum bag+neck shoulder mask group). Then each group was further divided into CBCT scan group and EPID group for veriifcation before treatment delivery. We matched the EPID images with the DRRs and acquired the set-up errors in x, y, z axis. Setup errors of CBCT were calculated according to its matched and planned CT images in left-right (x), superior-inferior (y) and anterior-posterior (z) directions. Paired t-test was used to evaluate the differences. Results:In the pillow+head neck shoulder mask group, the set-up errors of CBCT in the x, y, z axis were x (0.67±2.01)mm, y (0.51±1.71)mm and z (0.57±2.04)mm, respectively. The errors of EPID were x (0.69±2.19)mm, y (0.54±2.03)mm and z (0.61±2.11)mm. In the vacuum bag+head neck shoulder mask group, the set-up errors of CBCT in the x, y, z axis were x (0.42±1.81)mm, y (0.33±1.55)mm and z (0.50±1.75)mm, respectively. The errors of EPID were x (0.44±1.87)mm, y (0.43±1.70)mm and z (0.54±1.77)mm. The vacuum bag+head neck shoulder mask ifxed technique was more accurate when compared to the pillow + head neck shoulder mask ifxation method (P<0.05). Conclusion:CBCT and EPID were similar in detecting set-up errors for the NPC patients. However, the vacuum bag+neck shoulder mask ifxed technique was more accurate when compared to the pillow+head neck shoulder mask ifxation method.