Objective To investigate the relation of peripheral leukocyte total and its differential counts with urinary albumin(UAlb)in patients with type 2 diabetes.Methods The 564 subjects with type 2 diabetes were stratified according to UAER levels.The total and differential leukocyte counts of peripheral blood were measured.Demographic and potential metabolic confounding factors were analyzed with multiple correlation and logistic regressions to evaluate the effects of leukocyte counts on UAER.Results With the increase of UAER,the peripheral total leukocyte,neutrophil,monocyte,eosinophil and basophil counts increased.In contrast,the lymphocyte count decreased.The differences persisted even after adjusting the influence of age,sex,duration of diabetes and other known risk factors.Conclusions Our study shows that peripheral leukocyte counts,even within the normal range,are related with UAlb in subjects with type 2 diabetes in a dose-dependent manner.

Objective To compare the levels of serum high sensitivity C-reactive protein(hsC-RP) among subjects with normal fasting glucose plus normal glucose tolerance(NFG/NGT),IFG,IGT and IFG plus IGT,and to analyze the related risk factors. Methods 443 nondiabetic subjects aged 39-65 years were seperated into four groups:NFG plus NGT,IFG,IGT and IFG plus IGT.The serum hsC-RP levels and related factors were analyzed. Results Compared with IFG subjects,IGT subjects had higher hsC-RP levels.No differences in hsC-RP levels were found between NFG plus NGT group and IFG group, as well as between IGT group and IFG plus IGT group.Stepwise multiple regression showed that BMI and HOMA-IR were independent predictors of hsC-RP. Conclusions IGT subjects have significantly higher serum hsC-RP level than IFG subjetcts. The serum level of hsC-RP is associated with insulin resistance and the components numbers of metabolic syndrome.

0 05). In high grade squamous intraepithelial lesion (HGSIL), the differences between the laser treated group and either LLETZ or total hysterectomy groups turned into normal rate was significantly (P0 05).Conclusions Expectant treatment for CIN I is safe in a reliable patient population. LLETZ is a safe and effective treatment for HGSIL. The long-term efficacy of LLETZ should be investigated and assessed by extending the period of follow-up.

It has been preliminarily demonstrated that CIAPIN1 plays an essential role in normal tissue and is closely related to tumor formatin and development, prognosis and multiple drug resistance. CIAPIN1-based target therapy may provide a novel thinkingpathway in cancer treatment.

he proangiogenic effect.

The sonographie diagnosis of suhcutaneoyus nodules caused by lupg flukes in ten cases from the mountainous area of Xiangxi was reported.According to their ultrasonographic features,these nodules could be divided into three types:the substantial(one case),anechoic(two cases),and mixed type(seven cases).The sonographic characteristics,the pathotogic stages and the cytology of the subcutaneous nodules caused by lung fluke these cases were discussed.

Objective To observe efficacy of Pulmicort in treatment of capillary bronchitis.Methods Children with capillary bronchitis were randomly divided into two groups,ninty-eight cases of study group were treated with Pulmicort,fifty-eight cases of control group were treated with common therapy,observe clinical symptom:cough,breathes heavily. Results Two groups efficiency were 93.8% and 72.4% respectively.The study group was significantly better than that in control group. Conclusion Pulmicort inhalation in treatment of children with capillary bronchitis are effective.

Objective To study the changes in and correlations between the partial pressure of end-tidal carbon dioxide (PETCO2) and the coronary perfusion pressure during cardio-pulmonary resuscitation (CPR) based on the cardiac arrest dog models of ventricular fibrillation by electric shock. Methods 36 healthy dogs were evenly randomized into 3 groups including 4 minutes close-chest CPR(CCCPR) group, 4 minutes open-chest CPR(OCCPR) group, and 8 minutes OCCPR group. There were 12 dogs in each group, half male and half female. In the process of CPR, all parameters about PETCO2 and CPP were recorded. Results In the 4 minutes CCCPR group, the correlation coefficient between the CPP and the PETCO2 was 0.992 (P<0.05), which was in positive linear correlation. In the 4 minutes OCCPR group, the correlation coefficient between the CPP and the PETCO2 was 0.937 (P < 0.05), which also showed positive linear correlation. In the 8 minutes OCCPR group, the correlation coefficient between the CPP and the PETCO2 was 0.952 (P<0.05), and was also in positive linear correlation. The percentage of ROSC was 66.7(8/12) in the 4 minutes CCOPR group, 100%(12/12) in the 4 minutes OCCPR group and 58.3%(7/12) in the 8 minutes OCCPR group. There were statistical differences in CPP, PETCO2 between models with ROSC and without ROSC at 1, 2, 5, 10, 15 and 20 mins of CPR (all P<0.05). Conclusions This research shows that there is a close positive linear relationship between the coronary perfusion pressure and the PETCO2, and PETCO2 could be used to evaluate the prognosis of the CPR.

Objective To investigate whether MEG3 involved in the development of retinoblastoma by down-regulating the expression of P53 protein.Methods The MEG3 expression of retinoblastoma tissues and corresponding non-tumor tissues were detected by quantitative real-time PCR (qRT-PCR).Retinoblastoma cell lines SO-RB50 or HXO-RB44 were transfected with pcDNA-MEG3 or siRNA-MEG3,after which cell apoptosis was tested by flow cytometry and P53 protein expression was tested by Western blot.Results MEG3 expression of retinoblastoma tissues was significantly reduced compared with corresponding non-tumor tissues(P =0.014).MEG3 level was significantly increased in pcDNA-MEG3 transfected SO-RB50 cells (P =0.002) and significantly decreased in siRNA-MEG3 transfected HXO-RB44 cells (P =0.004).Flow cytometry showed that the SO-RB50 cells apoptosis was significantly increased with the MEG3 over-expression(P ＜ 0.05),as well as the HXO-RB44 cells apoptosis was significantly decreased with the MEG3 knockdown(P ＜ 0.05),compared with the control group,respectively.Furthermore,Western blot showed that P53 protein level was significantly increased after SO-RB50 transfected with pcDNA-MEG3 (P ＜ 0.05),while significantly decreased after HXO-RB44 transfected with siRNA-MEG3 (P ＜ 0.05),compared with the control group,respectively.Conclusion MEG3 is down-regulated in retinoblastoma,affect the development of retinoblastoma,and may induce the retinoblastoma cell apoptosis by promoting the expression of P53 protein.

Objective To analyze the National Natural Science Foundation-supported papers on oncology published by domestic authors from 2013 to 2015 and existed problems. Methods The key words in the National Natural Sci-ence Foundation-supported papers on oncology published by domestic authors from 2013 to 2015 and SCI-covered journals and Chinese institutions that published the National Natural Science Foundation-supported papers on on-cology from 2013 to 2015 were analyzed by bibliometrics. Results The number of the National Natural Science Foundation-supported scientific projects and funds, the number of the National Natural Science Foundation-sup-ported papers on oncology published by domestic authors, and the academic level of SCI-covered journals that pub-lished the National Natural Science Foundation-supported papers on oncology from Chinese authors increased year by year from 2013 to 2015 . General and medical colleges and universities with affiliated hospitals or national key laboratories were the leading force in oncology. The hot spots in oncology were focused on basic research and malig-nant tumors. Conclusion The National Natural Science Foundation plays an active role in promoting the develop-ment of oncology in China. Although it-supported papers on oncology published by domestic authors increase year by year, problems are still existed, such as imbalance of institutions that publish papers on oncology and insuffi-cient influencing power of papers published by domestic authors.