1.Risk factors of recurrent ischemic stroke in elderly patients
Jie XU ; Yi WU ; Weibo LU ; Jie CHEN ; Jie LIU
Chinese Journal of General Practitioners 2012;11(3):215-216
Five hundred elderly patients with ischemic stroke admitted from January 2008 to December 2010 were enrolled in the study,including 352 recurrent cases and 148 primary cases.There was a positive correlation of stroke recurrence with age,blood pressure,blood glucose and lipid levels,smoking and alcohol consumption of patients(P <0.05 ); while the stroke recurrence was negatively correlated with physical exercise(P < 0.05).Stepwise multiple regression analysis indicated that the blood pressure,blood glucose and lipid levels were risk factors for the recurrence of ischemic stroke in elderly patients.
2.MedDRA and its applications in statistical analysis of adverse events.
Acta Pharmaceutica Sinica 2015;50(11):1396-1401
Safety assessment in clinical trials is dependent on an in-depth analysis of the adverse events to a great extent. However, there are difficulties in summary classification, data management and statistical analysis of the adverse events because of the different expressions on the same adverse events caused by regional, linguistic, ethnic, cultural and other differences. In order to ensure the normative expressions, it's necessary to standardize the terms in recording the adverse events. MedDRA (medical dictionary for regulatory activities) has been widely recommended and applied in the world as a powerful support for the adverse events reporting in clinical trials. In this paper, the development history, applicable scope, hierarchy structure, encoding term selection and standardized query strategies of the MedDRA is introduced. Furthermore, the practical process of adverse events encoding with MedDRA is proposed. Finally, the framework of statistical analysis about adverse events is discussed.
Adverse Drug Reaction Reporting Systems
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standards
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statistics & numerical data
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Databases, Pharmaceutical
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standards
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Humans
4.Thinking on contents and methods of research on inheritance of prestigious TCM doctors’ experiences
Jingqing HU ; Jie LU ; Ximing LIU ; Zhizheng LU
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(10):-
The inheritance of prestigious TCM doctors' experiences is not only important for improving the level of health protection and developing the academic level of TCM in our country, but also an urgent research topic that need to be worked on. In this paper, the contents and methods of research on the inheritance of prestigious TCM doctors' experiences are discussed. There are three main research issues: the clinical experiences, the academic thoughts, and the ethics of prestigious TCM doctors. And when doing research on the methods, these problems should be paid attention to: study prestigious TCM doctors' clinical experiences, academic thoughts and ethics at the same time; start the research with trying to find a doctor's own character by comparison; understand the origin and development of a doctor's academic thought from the culture background; pay attention to the process of making tacit knowledge explicit; do more researches on the evaluation, promotion and application of prestigious TCM doctors' experiences based on EBM (evidence-based medicine).
5.Nursing Quality Control in Hospital Infection: An Evaluation of Its Effects
Xiaolian LU ; Jie LIU ; Lixin LIU ; Wei TANG
Chinese Journal of Nosocomiology 2006;0(12):-
OBJECTIVE To provide scientific basis for the control of hospital infection,and then the effects of nursing quality control were evaluated. METHODS There was significant difference in many targets of hospital infection. RESULTS The nursing quality control was strengthened by the following measures.The administration of hospital infection net be established,the environmental sanitation and sterilization in the medical matter be supervised,and the rules and regulations be enforced in the normal works of nursing against hospital infection. CONCLUSIONS Nursing quality control is very important in the control of hospital infection.
7.Experience of LU Zhi-zheng to apply tenuifolia.
Qiu-feng WANG ; Zong-lian LIU ; Jie LU
China Journal of Chinese Materia Medica 2015;40(19):3870-3872
Professor LU Zhi-zheng, one of the first traditional Chinese medicine masters, is good at using tenuifoliain clinical practice, which often brings unexpected surprises. Lu said, tenuifolia is a mild herbal medicine with the nature of upward dispersion and outward penetration but not dryness. Tenuifolia has the following functions: making people conscious, relieving sore throat, diverging incubated diseases, regulating functional activities of qi, sending up Yang, dispelling wind evil and eliminating dampness, and activating collaterals to relieve pain. When well used, it will not only enhance the effect of monarch drug, but also restrict the impetuosity nature in a prescription, achieving better efficacy.
Adult
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Brassicaceae
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chemistry
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Dizziness
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drug therapy
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Drugs, Chinese Herbal
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administration & dosage
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Female
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Humans
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Male
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Phytotherapy
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Rhinitis, Allergic
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drug therapy
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Stomach Diseases
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drug therapy
8.Effects of zoledronic acid in the treatment of breast cancer.
Jie CHEN ; Zhi-yan LIU ; Lu-jun ZHAO
Chinese Journal of Oncology 2011;33(4):318-319
Animals
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Antineoplastic Agents
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therapeutic use
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Bone Density Conservation Agents
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therapeutic use
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Bone Neoplasms
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drug therapy
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secondary
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Breast Neoplasms
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drug therapy
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pathology
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Chemotherapy, Adjuvant
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Diphosphonates
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therapeutic use
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Female
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Humans
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Imidazoles
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therapeutic use
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Neoadjuvant Therapy
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Osteoporosis
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prevention & control
9.Two radiotherapy treatment planning systems in comparison of dose calculating results for simulation phantom,patients and homogeneous organization phantom
Zengjun ZHAO ; Jie LU ; Yong YIN ; Baosheng LI ; Tonghai LIU
Chinese Journal of Radiation Oncology 2008;17(4):308-311
Objective Using Eclipse and Pinnacle3 V 7.4f treatment planning sytems (TPS) for dose calculation of the CT images of simulation phantom,patients and homogeneous organization phantom,to compare the differences between the two TPS for the calculation of non-uniform organizations.Methods For the CT images of simulation phantom,patients and homogeneous organization phantom,the calculating results between the two TPS were compared,including the common used clinical indexes of V20 and V30 of the lung,D95 of the planning target volume,the doses of the ISO and eight points of interest inside ISO slice.Resuits For simulation phantom and patients,although the calculating differences of the isocenter doses between the two TPS were small,the differences of other indicators were large.For example,when using secondary collimator irradiation,the maximal D95 difference of planning target volume reached 10.17%for patients and 4.64%for simulation phantom.When using muhileaf collimator irradiation,the maximal D95 difference reached 10.74%for patients and 5.66%for simulation phantom.Sometimes the dose differences of points 1-4 at the edge of planning target volume were more than 10%.In addition,the V30 differences of the lung were large too.But for the homogeneous organization phantom,the calculating differences were small.Conclusions The calculating differences between the two TPS are less for simulation phantom than for patients,and more for simulation phantom and patients than for homogeneous organization phantom.
10.A pilot study to evaluate the invasiveness of mandible ameloblastoma on ultrasonography
Linguo LU ; Jibin LIU ; Jie YANG ; Qiuhua XU ; Shan YAN
Chinese Journal of Ultrasonography 2010;19(9):793-796
Objective To evaluate and demonstrate ultrasonographic characteristics of mandibular ameloblastoma with active proliferation. Methods Nineteen subjects with ameloblastomas in the mandibles were examined with ultrasonography. In addition to sizes,internal echoes,the research was focused on blood flow of the tumors and destruction of mandibles. Ultrasonographic appearances of the tumors were compared with histopathological findings. Sensitivity and specificity of Doppler flow signals and destruction of mandibles for prediction of active tumor proliferations were calculated. Results Fifteen cases (79%)showed no or minimal flow signals on color Doppler flow imaging(CDFI), whereas the remaining 4 lesions demonstrated abundant flow signals,in which 3 cases were confirmed histopathologically with active tumor proliferations. The sensitivity and specificity of the Doppler flow signals for prediction of active tumor proliferations were 100% and 94%, respectively. Fourteen cases (74%) showed the mandibular cortices were thin but continuous,among the remaining 5 lesions showed local cortices destruction,3 of them were confirmed histopathologically with active proliferations. The sensitivity and specificity of the destruction of cortical bone for prediction of active tumor proliferations were 100% and 88 %, respectively. Conclusions Ultrasonography can be used as a new effective supplementary diagnostic method for mandibular ameloblastomas. CDFI of tumor vascularity and destruction of cortical bone could be used to predict active tumor proliferations and invasiveness.