Objective:To completely solve the traditional ECG examination mode, establish ECG diagnosis center in hospital, realize the automation of the whole process of ECG.Methods: Demonstrate the structure and function of Network ECG information management system software and hardware, describes the key technology used in the process of implementation.Results: Lead to centralized storage, management and diagnosis of the ECG data, achieve data sharing through integration with HIS, PACS system.Conclusion: Optimized the ECG examination process, improve doctor's efficiency and ECG report quality, make it convenient for the doctor to consult and analyze ECG data, provide medical care and powerful technical support for teaching and research.

Hospital digitization is a systematic process and has to be accomplished by stages. This paper discusses the key points of all stages of hospital digitization to enhance the control level of hospital.

Objective:To solve the management problems of using mobile cart, PDA, flat-panel computer and other mobile devices in hospital, promote the evolution of mobile device management to intelligent management. Methods: Select the mobile device management system for hospital use based on their own characteristics.Results: Manage all the mainstream operating system and terminal equipment; manage the hardware and software of mobile terminal and assets in hospital.Conclusion: Improve the management, reduce the maintenance workload, save the cost of operation and maintenance.

Epidemiological studies have shown that patients with diabetes are prone to have depression and anxiety.This article reviews the evidence,mechanism,complications and strategy of selective serotonin reuptake inhibitors paroxetine in treatment of depression and anxiety in patients with type 2 diabetes mellitus.

The study of tumors' proteomics is a research hotspot in China and abroad in recent years.The development of theory and technology in proteomics has provided new ideas and research field for cancer research.This paper reviewed the commonly used technical means of proteomics and its research progress on diagnosis,therapy and other aspects of pancreatic carcinoma.

Objective:To explore the effect of Zinc finger protein 185 (ZNF185) on the migration of human gliocytoma cells. Methods: ZNF185 protein expression in human gliocytoma and its adjacent normal tissues was detected through Western blot. The ZNF185 gene was cloned and transfected into the human gliocytoma cell line SF767. ZNF185 cells were located through immunofluo-rescence staining, and cell migration was analyzed using the cell scoring method. Results:CZNF185 protein expression was lower in the human gliocytoma cell line than in normal para-neoplastic tissues. ZNF185 protein was mainly expressed in the cytoplasm and cell membrane of the human gliocytoma cells and was co-located with F-actin. ZNF185 overexpression repressed the migration of human gliocytoma cells. Conclusion:ZNF185 represses the migration of human gliocytoma cells by binding to F-actin.

Objective To explore the role of zinc finger protein (ZNF)185 in the proliferation of human glioma cells. Methods Human glioma tissues and tumor adjacent tissues were obtained from glioma patients diagnosed pathologically in Tangshan Gongren Hospital from January 2011 to December 2013. Total protein was extracted from different tissues. The ZNF185 expression was detected by Western-blot assay. Total RNA was extracted from tumor adjacent tissues. ZNF 185 cod?ing sequence was obtained by RT-PCR and inserted into pEGFPC2 plasmid to construct the ZNF185 expression vector. Li?pofactamine2000 was used to transfect the ZNF185 expression vector to human glioma cell SF767. pEGFPC2 blank vector transfected SF767 cells were used as control. Changes of cell cycle were analyzed by flow cytometry, and cell proliferation was analyzed by MTT assay. Results The expression of ZNF185 decreased significantly in human glioma tissues compared to that of tumor adjacent tissues(P<0.01). The over expression of ZNF185 in SF767 resulted in the increased proportion of cell cycle G0-G1phase, but decreased proportion of S phase(P<0.05). Furthermore, the cell proliferation was significantly inhibited in the ZNF185 over-expressed SF767 cells compared with that of blank vector transfected cells(P<0.05). Con?clusion ZNF185 plays an inhibitory role in cell proliferation of human brain glioma cells.

Objective To discuss the death causes in patients diagnosed initially as mild to moderate craniocerebral trauma. Methods A retrospective study was done on 44 deaths, who arrived at the emergency department with a mild or moderate craniocerebral trauma from 2004 to 2008. There were 35males and nine females at age range of 19-85 years (average 53 years). There were 17 patients with Glasgow coma score (GCS) 13-15 points and 27 with GCS 9-12 points. The causes of injury included road traffic accidents in 18 patients, tumbling in 18, falling from height in six and unknown factors in two respectively. Of all, 18 patients underwent surgical intervention and 26 received conservative therapy.Results The causes of death were cerebral hernia in 25 patients (57%), various complications in 15(34%), multiple trauma in two (5%) and sudden death in two (5%) respectively. Conclusions The primary death cause is cerebral hernia in the patients with mild to moderate craniocerebral trauma.Attention should be paid to prevention and control of complications and multiple trauma during treatment of primary head injury. The prognosis may be badly affected by human factors.

Objective To systematically review the risks and effectiveness of combined caudate lobectomy in Klatskin tumor.Methods A systematic literature search was conducted on PubMed,Embase,Cochrane Library,Scopus,CNKI databases and Chinese Bio Medical Literature (CBM).A systematic review and meta-analysis of the current literatures were conducted based on the PRISMA guideline.Odds ratios were calculated using the Mantel-Haenszel method.The primary outcome variables included safety,effectiveness of combined caudate lobectomy and its impact on long-term survival.Results Nine out of 312 articles were included.Results showed caudate lobectomy did not increase the incidence of postoperative complications (OR ＝ 1.15；95 ％ CI 0.74-1.81；P ＞ 0.05),but improved R0 resection rate (OR ＝ 4.81；95 ％ CI 2.72 ～ 8.53；P ＜ 0.01) and long-term survival in these patients (OR ＝ 0.20；95％ CI 0.11 ～ 0.39；P ＜0.01).Conclusion Combined caudate lobe resection is a safe and effective treatment for Klatskin tumor.

OBJECTIVE:To provide reference for the timely and accurate judgment of drug fever induced by Piperacillin sodi-um and tazobactam sodium for injection and rational drug use in the clinic. METHODS:The medication,clinical manifestations, laboratory examination results and the physician treatment of 30 inpatients with drug fever induced by Piperacillin sodium and tazo-bactam sodium for injection from Sept. 2013 to Sept. 2014 were analyzed retrospectively and statistically. RESULTS:Most of the drug fever induced by Piperacillin sodium and tazobactam sodium for injection occurred in continuous 7 to 14 d medication,and the cumulative dosages were between 1.3 to 2.7 g/kg;73.3% of the 30 patients had fever during the intravenous drip,with body temperature mainly≥38.5 ℃;the elevation of eosinophil and slightly increase of serum C-reactive protein (CRP) and blood cell sedimentation rate (ESR) could be used as observation indexes of drug fever,but the leucocyte reduce could’t be suitable;the body temperature dropped to normal within 24 to 48 hours after stopped using it. CONCLUSIONS:The drug fever induced by Piperacillin sodium and tazobactam sodium for injection has no correlation with the patients’gender or age,and no special diagnos-tic criteria. But it has certain correlation with duration of medication,cumulative days and dosages and it can be used as reference of judgment with the combination of hematological examination index. Clinicians should improve the understanding and attention about drug fever to stop using suspicious drug in time.