Twenty two patients with variant types of absolute glaucoma were treated by surface cyc-lodiathermy. Follow-up time averages 3.5 years, without medication, intra-ocular pressure (IOP) was well controlled in 13 patients; IOP was decreased by 50% and the symptoms were relieved in two patients. The effective rate was 68%. In this paper, the technique and comp-lication of this operation were introduced. The technique rather simple. The effect of the operation is satisfactory, and complication is few. Therefore, we adopt cyclodiatharmy is a better procedure for absolute glaucoma

A comparison of plant and animal stem cells can highlight core aspects of stem-cell biology. In both kingdoms, stem cells are defined by their clonogenic properties and are maintained by intercellular signals. The signaling molecules are different in plants and animals stem cell niches, but the roles of argonaute and polycomb group proteins suggest that there are some molecular similarities.
Animals ; Plant Cells ; Signal Transduction ; Stem Cells ; cytology ; metabolism

Currently, histological and molecular methods are considered for the treatment of advanced non-small cell lung cancer (NSCLC). Single-agent epidermal growth factor receptor tyrosine-kinase inhibitors (EGFR-TKIs) and anaplastic lymphoma kinase in-hibitors (ALK-TKIs) have been used as standard first-line therapies for patients with active EGFR mutation and ALK rearrangement, re-spectively. However, to date, the single-agent EGFR-TKIs as the first-line therapy for patients with known EGFR mutations has been demonstrated to provide a prolonged progression-free survival but does not affect overall survival (OS). Physicians these days focus on improving the OS of patients with advanced NSCLC. To patients with EGFR mutation, combining and maintaining EGFR-TKIs with chemotherapy could be a promising approach. In this article, various ways of combining EGFR-TKIs with chemotherapy were explored.

A series of 5-amino-2-( benzylthio ) thiazole-4-carboxamide derivatives were designed and synthesized to discover novel compounds with anti-tumor activity. Compounds DDO-5401-DDO-5416 were synthesized using 2-amino-2-cyanoacetamide as the start material. The structures of the synthesized compounds were confirmed by IR, 1 H NMR and ESI-MS. The in vitro anti-tumor activities of the synthesized compounds were determined by MTT assay in HCT116 , HepG2 , A549 , MDA-MB-231 and MCF-7 cell lines. Target compounds showed good anti-tumor activity especially in A549 cell line. SAR study showed that electron donating groups were more favorable than electron absorption ones. Compound DDO-5413 exhibited noteworthy activity in MDA-MB-231 and MCF-7 cell lines with IC50 value lower than the positive reference dasatinib. It suggested that DDO-5413 might be the candidate for further investigation.

Levels of lipids, lipoproteins and apolipoproteins in 59 patients with cerebral infarction were compared before and after therapy. Evening—Primrose—oil group (EPOG 32cases) was treated with EPO and routine drugs (low molecular dextran, piracetam, vitamine E), the routine—drug group (RDG 27cases) was treated only with above- mentioned routine drugs. After treating for one month the lab data demonstrated that the(HDL—c, HDL2—c and apo A—I levels in EPOG were significantly higher than)before treating (P0.05). All parameters above- mentioned in RDG had no significant change after treating.

One carboxypeptidase producing strain was obtained from 28 proteinase producing strains, by analyzing the products of peptides hydrolyzed by the enzyme of the strains According to the characteristics of the morpha and the colonies, the screened strain belongs to aspergillus genera The activity of its carboxypeptidase reached maximum at the 84th hour after fermentation

Effects of carbon resource, nitrogen resource, metal irons and surface detergents on the production of pro topectinase by strain Aspergillus sp XZ 131 were studied The results showed that pectin substances were essential for the strain to produce protopectinase The enzyme activity reached to 300 U/mL, when(NH 4) 2SO 4 and(NH 4) 2HPO 4 were used as nitrogen resource Ca 2+ and Tween 20 were able to enhance the production of the enzyme The optimum composition of the medium was citrus peel powder 1g,(NH 4) 2SO 4 2g,CaCl 2 0 015g,Tween 20 0 2mL,KH 2PO 4 3 8g,K 2HPO 4?3H 2O 0 2g,H 2O 100mL,pH 6 5。

Objective To evaluate the clinical efficacy of sodium tanshinone IIA sulfonate(STS)in the treatment of ad-vanced schistosomiasis. Methods Fifty cases with advanced schistosomiasis admitted to the Touzao Township Hospital of Dong-tai City during the period from November 2012 to November 2013 were treated with STS for 10 days,and the internal diameter of the portal vein,levels of ALT,AST,γ-GT,PIIIP,CIV,HA and LN were measured and compared before and after the adminis-tration of STS. Results The mean levels of all serological parameters except HA were within the normal range before STS treat-ment,while the highest positive rate was detected inγ-GT(26.0%)and HA(54.0%). Following the STS treatment,the mean lev-els of all parameters and the positive rates reduced,with the greatest reduction observed inγ-GT(36.7%)and HA(37.8%);how-ever,the mean HA level was still higher than the normal range. The mean internal diameter of the portal vein reduced from(10.5± 1.7)mm before the STS treatment to(9.8±1.3)mm after the STS administration,with a significant diffrtence(P<0.05). Conclu-sion STS appears effective in the treatment of advanced schistosomiasis.

Antiangiogenesis therapy is one of the most common anticancer therapies. Bevacizumab is a monoclonal antibody that blocks the binding of the vascular endothelial growth factor to its high-affinity receptors. It is the only antiangiogenic agent approved for the first-line treatment of advanced non-small cell lung cancer (NSCLC). Many recent studies have attempted to determine the suit-able partners of bevacizumab in first-line treatment of NSCLC and evaluate its efficacy and safety as a second-line or beyond and con-tinuous treatment of beyond disease progression in patients with advanced NSCLC. This review summarizes current clinical research about the efficacy and safety of bevacizumab in the treatment of advanced NSCLC.

Objective By testing the particle removal efficiency of LG Electronics Company's two types of plasma air cleaners,to explore more scientific and reasonable methods for evaluating the purifying effectiveness of indoor air cleaners so as to obtain scientific and contrastable experimental data and calculating results. Methods This evaluating method referred to Standard Examination Method of Portable Household Electric Cord-Connected Room Air Cleaners of America (ANSI/AHAM AC-1-2000) and used one of indexes regu lated in standard Clean Air Delivery Rate (CADR) as the main evaluating index of the effectiveness of indoor air cleaners,meantime several kinds of domestic and international current evaluating indexes were adopted to synthetically evaluate decontaminating function of the air cleaners. Results The index of CADR could accurately and objectively manifest the true decontaminating function of indoor air cleaner. But if using the index of purifying efficiency to reflect the purifying effectiveness of air cleaners,pollutant's natural decay rate and initial concentration should be considered and at the same time other experimental conditions should be given out. Conclusion The establishments of accurate testing methods and accurate expressions of testing results were the sufficient and essential conditions for accurate evaluation on testing objectives.