Epstein-Barr Virus (EBV) is the first human virus related to oncogenesis.EBV infection is associated with inflammatory bowel disease (IBD) with unknown causality.The prevalence of EBV in intestinal tissue from patients with IBD is significantly higher and related to the exacerbation of the disease and refractory IBD.Immunosuppressive therapy has improved outcomes associated with IBD.However,it is also associated with an increased risk of opportunistic infection,and lymphoproliferative disorders (LDs) maybe due to EBV infection.Here we review our current understanding of the pathogenesis of EBV infection in colonic mucosal inflammation,EBV-induced disease exacerbation,lymphomagenesis in IBD,and clinical approaches therefrom.

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Fibrosis is the major cause of corneal scarring.Transforming growth factor-beta (TGF-β) plays a key role in corneal homeostasis and repair.Corneal epithelial basement membrane is thought to be the important barrier of corneal epitheliumstroma interaction.In different stages of corneal wound healing,the isoforms of TGF-β have different temporal and spatial expression.The integrity of basement membrane is a critical factor of these procedures.The temporal and spatial distributions of TGF-β isoforms play the crucial roles in cell migration,proliferation,phenotype changes and deposition of extracellular matrix in corneal wound healing.It is the mechanism of corneal scarring and scar-free healing.This article reviews recent articles to elucidate the biological functions of TGF-β and the temporal and spatial distribution of its isoforms in corneal wound healing.

In recent years, great achievements have been made in the therapy of viral hepatitis B and viral hepatitis C, as majority of hepatitis C patients can be clinically cured.Though current antiviral therapy is still unable to eradicate hepatitis B virus in infected hepatocyte and few patients could achieve HBsAg loss or seroconversion, end-stage liver disease like cirrhosis, liver failure and hepatocellular carcinoma have been dramatically prevented.The advances in treatments have prompted the progress in laboratory diagnosis of viral hepatitis.Here we review the progress in the field.

BACKGROUND:Intratubal contraceptive devices are simple and effective, which can cause less interference on female reproductive function and endocrine balance.
OBJECTIVE:To explain the advantages and adverse effects of shape-memory intratubal contraceptive material and other intratubal contraceptive materials.
METHODS:A computer-based search of Wanfang, CNKI and PubMed was performed to search related articles concerning shape-memory intratubal contraceptive material and other intratubal contraceptive materials published from 1996 to 2013.
RESULTS AND CONCLUSION:The main intratubal contraceptive materials include memory metal biomaterials, non-degradable polymer biomaterials, and degradable polymer biomaterials. After implantation, the memory-shape intratubal contraceptive device plays a stimulating role in the tubal epithelium for a short time, but the effect on the mucosal epithelial layer of the fal opian tube is transient. With the increasing time of implantation, inflammatory reactions of the tubal epithelium relieve gradual y with repair of vil i on the tubal wal , indicating there is a reproductive tissue basis of fal opian tube recanalization. Polyethylene materials are characterized as high impact resistance, abrasion resistance, excellent stability to chemical drugs, water absorption, electric insulation, and bioinert, which are used as stent materials of almost al the intrauterine devices. Silicone is characterized as heat resistance, cold resistance, non-toxicity, resistance to biological aging, chemical stability, physical inertia, physical and mechanical properties, and silicone, after implantation into human body, cannot cause foreign body reaction. Polylactic acid has good chemical inertness, biocompatibility and ease of processing, and may be stil present in the body after 5 years of implantation.

Purpose:To investigate whether transforming growth factor ?1 (TGF ?1) pathway is involved in the mechanism of dexamethasone (Dex) mediated proliferation inhibition in ovarian cancer cell line HO 8910.Methods:To analyse cell proliferation and cell cycle distribution by cell counts and flow cytometric analysis, respectively ; to determine the expression levels of TGF ?1 and its two receptors, T?R Ⅰ and T?R Ⅱ , by quantative RT PCR, ELISA and(or) immunocytochemistry methods.Results:Dex induced a G 0 /G 1 cell cycle arrest in HO 8910 cells, and it up regulated T?R Ⅱ expression in a concentration dependent manner.The level of T?R Ⅱ mRNA was the highest after treatment with Dex for 8 hours, with 1.4 fold more than that of control at concentration of 10 -7 mol/L ( P

Objective To investigate the risk factors of renal damage in children with Henoch-Schonlein purpura(HSP).Methods Two hundred and ninety-two children with HSP admitted to the First Affiliated Hospital of Anhui Medical University from Jan.2007 to Mar.2008 were reviewed.According to the findings urinary examination,children were divided into non-renal damage group(183 cases)and renal damage group(109 cases).Clinical data(gender,age,predisposing factors,rash repeated frequency,system damage)and laboratory examination [blood WBC,PLT,IgA,fibrinogen(FIB),TT,ASO,C3,C4] of 2 groups were compared,and then multiple regression analysis were performed to evaluate the risk factors of renal damage in children with HSP.Results 1.Among them,37.33% cases had renal da-mage,and hematuria and proteinuria manifestations were common.2.Simple Logistic regression showed that age was at least 8 years old and the number of purpura relapses was at least 4 times,increased serum FIB levels had significant difference between the 2 groups(P=0.030,0.000 and 0.011,respectively).There was no significant difference between the 2 groups in other clinical data and laboratory examinations.3.Mutiple Logistic regression showed that when the number of purpura relapses was at least 4 times,increased serum FIB levels were the risk factors of the renal damage(P=0.000 and 0.029,respectively);while there was no significant difference for the children who were at least 8 years old between the 2 groups(P=0.175).Conclusion When the number of purpura relapses is at least 4 times,increased serum FIB levels are the risk factors of the renal damage in children with HSP.

This paper pondered thoroughly the analysis of the mental status of earthquake victims,the preparation,operational measures and steps,and remarkable issues in post-earthquake psychological crisis intervention,in order to provide mental support for the post-earthquake reconstruction.

The quality of teaching staff is closely correlated with the development of students and educational career.Therefore,educational administrators should enhance their concepts of management,clarify requirement and quality of teaching staff under the circumstance of new curriculum reform,and explore effective approaches to enhancing the quality of teaching staff,so as to unceasingly improve the quality of teaching staff.

Objective To evaluate the accuracy of lung volume in pneumothorax by CT.Methods 1.17 artificial lung models were scanned by SHIMADZU SCT-7000 TH whole body scanner system and their volumes were determined by using the volume-calculated function of CT.2.The actual volume of the models were equal to the volume of water injection by the models.Results The actual and calculated volumes of lung were 2893.47?29.22 ml and 2894.32?28.47 ml respectively.A good correlation(?=0.9860,?