Glycogen storage diseases (GSD) are a group of inherited disorders characterized by enzyme defects that affect the glycogen metabolism. Hypoglycemia, hepatomegaly, splenomegaly and growth retardation are the main clinical manifestations. The enzymes affecting glycogen synthesis and degradation are varied.Consequently, the clinical manifestations are different because of different enzyme defection. Most patients treated regularly can obtain the normal growth and grow to adults, but still can be accompanied long-term complications by adulthood. Now some scientists find new modified cornstarch is superior to standard therapy in maintaining blood glucose levels. Gene therapy is still in the experimental animals.

Triple negative breast cancer(TNBC) is defined by the lack of estrogen receptor (ER) , progesterone receptor (PR) and human epidermal growth factor receptor-2 ( Her-2) expression. It is a subtype of tumor with distinct clinical and pathologic features and lacks effective targeted therapies. It is non - sensitive to endocrine therapy and targeted therapy drug herceptin, leaving chemotherapy as the mainstay of treatment The feature and the treatment of TNBC is the hotspot of resent research.

Objective To compare the accuracy of full field digital mammography (FFDM) and digital breast tomosynthesis (DBT) in predicting size of ductal carcinoma in situ (DCIS).Methods Totally 30 women pateints with DCIS confirmed by histology were analyzed retrospectively.Two radiologists measured the size of the lesions on FFDM,DBT images respectively,and compared with pathological results.Two kinds of inspection methods correlation with pathology were compared with Pearson correlation analysis.Results Size of DCIS measured by doctor 1 and doctor 2 between FFDM and histology had correlation (r=0.857,0.818,both P＜0.01),and those between DBT and histology also had correlation (r=0.924,0.885,both P＜0.01).Intraclass correlation coefficient (ICC) of two doctors was 0.947 on FFDM,and 0.908 on DBT.Conclusion DBT provides a better estimation of the size of DCIS.Two physicians had high consistency for lesion size evaluation.For DCIS with microcalcifications,both FFDM and DBT provide smaller estimations compared with pathology,thus a bigger surgical resection of lesion is needed.

Hereditary haemorrhagic telangiectasia(HHT) is a genetic autosomal-dominant disorder characterized by the presence of epistaxis,vascular telangiectasis in mucosal and cutaneous tissues,with visceral lesions and family history. However,many specialists or radiologists are still in lack of appreciation concerning the full range of consequences in diagnosis and their family relationship resulting the poor recognition of the disease. Understanding the diagnostic imaging and therapeutic measure for HHT will be critical,because of the continuous growth and risk existance of these arteriovenous malformations arousing early diagnosis,proper treatment,adequate follow-up and screening of the family.

OBJECTIVE To investigate probationer nurses' knowledge about nosocomial infection (NI) and clean operating-room. METHODS Survey among probationer nurses was performed by self-designed questionnaires. RESULTS 47% probationer nurses thought it very necessary to strength knowledge about NI before probation. The scores of clean operating-room knowledge was lower than that nosocomial infection (NI); The cognition rate among high educated probationer nurses were higher than low educated,P

Objective To survey the quantity of clinical practice of medical trainees in practice,analyze the status characteristics and main problems,and put preference for practice teaching administrative departments.Methods In June 2016,all students finishing internship in some military medical university were gathered and surveyed by the person in charge.Using self-made questionnaires,the students were asked to anonymously fill out the quantity of clinical practice by themselves respectively in different department and in various capacities.515 questionnaires were provided and 479 valid results were collected (93.0％).Using SPSS 16.0,the number of trainees in different genders,specialties and categories was analyzed by variance analysis and SNK test (22 comparison).Results The numbers of clinical practice as first assistants and second assistants in surgical medicine were the most,which were 5.70 and 5.29 in average,while those in specialty medicine were the least (al1＜2.85 in various capacities).The quantity of clinical practice in different specialties and sorts as second assistants in intemal medicine showed statistical significance (F=2.646,F=2.682;P=0.008,P=0.031) and SNK test showed that those in navy general practice medicine (5.81) and soldiers (4.59) operated more.The quantity of clinical practice in different specialties and sorts as first assistants in special medicine showed statistical significance (F=2.166,F=2.765;P=0.029,P=0.027) and SNK test showed that those specialties in pharmacy (3.33) and clinical medicine (3.22) and soldiers (3.03) operated more.Conclusion The quantity of clinical practice of medical trainees has characteristics with surgical medicine most and there is no links with genders.In the departments with more opportunities,the differences among different groups are not obvious,while in the less operating departments,the students with higher motivations operate more.Therefore,these departments should focus on mobilizing the enthusiasm of students.Besides,the quantity of clinical practice in medical trainees should be looked upon objectively and the operations should be done under the guide of the teachers and on the basis of considering the security of patients.

This paper introduces such information of database server platform for military ″1″ hospital information system as its history, present status and progress. The IA-64 calculation platform based on open standard and Oracle 9i are also summarized. Upgrade experiment and evaluation are carried out, which all lay the foundation for the following upgrade of the server platform and can be referred to on relative functions.

Objective The purpose of the present study was to observe the muscle glucose metabolism by determining the changes in sarcolemma GLUT4 protein content and muscle AMPK activity in overtraining rats.Methods Twenty-seven SD rats were randomly divided into group A(sedentary),group B(underwent endurance exercise 60 minutes/day)and group C(underwent endurance exercise 120 minutes/day).Both exercise groups trained 6 days/wk for 9 weeks.Muscle glycogen,sarcolemma GLUT4 contents and muscle AMPK activity were determined after the 9-week training.Results Sarcolemma GLUT4 content and muscle AMPK activity increased,muscle glycogen contents tended to rise in group B as compared with that in group A.Sarcolemma GLUT4 content and muscle AMPK activity decreased,but muscle glycogen contents were equivalent in group C as compared with that in group B.Conclusion Muscle AMPK activity deceased,and the translocation of GLUT4 protein was inhibited in the overtraining rats.The results could not support a glycogen depletion hypothesis.

Present basic researches on hepatic stem cells have obtained great progress. It is believed that hepatic stem cells can differentiate into hepatic cells and biliary duct cells. Hepatic stem cells are isolated and cultured by two-step collagenase digestion method, density gradient centrifugation, centrifugal elutriation, fluorescent activation screening method and immunomagnetic beads screening method. Directional differentiation of hepatic stem cells is a complicated process, which is affected by exterior and interior cell factors under liver microenvironment where are beneficial to growth, differentiation and function of stem cells. Hepatocyte growth factor can promote the proliferation of hepatic stem cells, and accelerate the differentiation into mature hepatic cells. Transcription factor of hepatic cells play a crucial effect in regulating the differentiation of hepatic stem cells. Incomplete or abnormal differentiation of hepatic stem cells can be responsible for liver cancer. Hepatic stem cells are the potential carrier cells as a target gene for liver cancer.