The key mechanism of severe infection (sepsis) is systemic inflammatory reaction syndrome. Continuous blood purification (CBP) is helpful for treatment of sepsis through removing medium and large molecular weight inflammatory mediators. Clinical application and lab researches have confirmed that CBP can stabilize cardiopulmonary function in patients with severe sepsis. Continuous veno-venous hemodiafiltration, continuous plasma filtration absorption and high volume hemofiltration can play a role in lowering inflammatory mediators in plasma and tissue. CBP has revealed a good prospect in the treatment of severe sepsis in children.

Training technologies on life support for pediatric critical illness mainly include basic life support,pediatric advanced life support,neonatal resuscitation program,pediatric trauma life support,pediatric fundamental critical care support,and simulation-based medical education.This article introduced and summarized the contents of training technologies on life support for pediatric critical illness,and elucidated the status on each project and its vision.

Severe hand foot and mouth disease can lead to death when accompanied by neurogenic pulmonary edema. Early identifying involvement of central nervous system, focusing on the evidences of excited sympathetic nerve tension and high risks of neurogenic pulmonary edema, monitoring respiratory rate,dyspnea, cyanosis, fine and medium rales in lungs are critical to prognosis. Managing fluid loading strictly, decreasing intracranial hypertension, supporting actively respiratory function and strengthening airway management are key points for the treatment of neurogenic pulmonary edema.

Tetramine poisoning still occurs and seriously impairs children' s health. Some children suffered from brain injury or death. Diagnosing accurately as soon as possible, eliminating poison rapidly,using antidotes timely and controlling convulsion quickly are the crucial treatment principles.

In addition to parameter setting and mechanics monitoring,respiratory wavetorms are helpful for respiratory therapist in getting the real-time changes of respiratory mechanics and dynamically adjusting ventilator parameters.The curves of pressure to time,flow to time and volume to time accompanied by the loops of pressure to volume.flow to volume and pressure to flow can be displayed dynamically in new type ventilators.It will be definitely helpful to us to make good use of ventilator.

Hypertensive emergencies,though uncommon in children,are often involving severe organ dysfunction and potentially life threatening.Early recognition of hypertensive crisis and properly management to control the blood pressure are the key points of the treatment.Drug therapy is an important antihypertensive treatment.

Sepsis is a group of clinical syndrome in response to overwhelming inflammation,which is a major problem associated with high morbidity and mortality among critically ill patients.Recently,an abundance of basic and clinical findings suggest that stem cell can be attributed to anti-inflammatory,tissue healing and immunomodulatory,which may provide a promising idea in the treatment of sepsis.

The 2012 version of international guidelines for management of severe sepsis and septic shock got re-revised on the basis of the 2008 version.For pediatric severe sepsis,the 2012 version enforces initial resuscitation;develops detailed ant-infection measures;stresses isotonic crystalloid fluid resuscitation and the use of albumin,hetastarch is no longer recommended ;reduces the value of early use of dopamine,and clears the use of corticosteroids indications and the use of blood products;mechanical ventilation is recommended to use lung protective ventilation strategy; standardizes sedation and analgesia applications; clears the level of blood glucose control;others include blood purification,nutrition,stress ulcer prevention recommendations.

Brain injury is one of the most common diseases in PICU.Bedside electroencephalogram monitoring is the most commonly used to evaluate cerebral function.Bedside electroencephalogram monitoring includes continuous electroencephalogram,video electroencephalogram and cerebral function trends,such as amplitude integrated electroencephalogram,envelope and band power.

The incidence of invasive fungal infection in critically ill patients is increasing year by year. Its clinical manifestation lacks specificity which is difficult for early diagnosis. It′s hard to identify inva-sive fungal infection with fungal colonization in clinical practice. We need to find out the way to distinguish them.