A clinical study with 49 participants was started and completed at the height of the Covid-19 pandemic with the use of decentralized clinical trial (DCT) methodologies. All participants and the study team remained safe and were able to conduct the study efficiently. Patients were able to provide consent electronically, received experimental supplements and were given the option to provide feedback through the system’s telemedicine feature.

No abstract available.
Diagnosis, Differential* ; Humans ; Lower Urinary Tract Symptoms*

A noncontact mapping system (EnSite) was used for electroanatomical mapping of the bladder simultaneously with pressure flow study in three women with lower urinary tract symptoms. We selected the periods of obvious detrusor activity. Data were processed to remove baseline drift, and an envelope of electrovesicography (EVG) data was created. The correlation coefficient for the correlation between between the EVG envelope and the detrusor pressure (P(det)) was calculated. Bladder geometry was successfully created in all 3 patients. Simultaneous recording of EVG and pressure flow data was successful in 1 patient. Scatter plots were made of the highest correlation coefficient, showing a positive correlation between the P(det) and the envelope, and negative correlation between abdominal pressure (P(abd)) and the envelope. Minimal electrical activity could be observed. Significant weak to moderate correlation coefficients were found for the correlations between P(det) and EVG and between P(abd) and EVG.
Female ; Humans ; Lower Urinary Tract Symptoms ; Urinary Bladder* ; Urodynamics

The levels of prostaglandin E were studied in the urine of 25 female patients with irritative bladder symptoms but no evidence of organic disease or urinary infection (female urethral syndrome). Twenty five healthy women served as a control group. A significant elevation of prostaglandin E in the urine of patient with female urethral syndrome was demonstrated (by Wilcoxon rank sum test; z= -2.32, p<0.05). The results suggest that prostaglandins may be responsible for the lower urinary tract symptoms in the patients. The potential beneficial clinical effects of prostaglandin syntheses inhibitors in treatingthe severe discomfort associated with urethral syndrome need to be evaluated further.
Female* ; Humans ; Lower Urinary Tract Symptoms ; Prostaglandins ; Urinary Bladder

PURPOSE: Although acute uncomplicated cystitis in women is relatively common, there have been few studies on lower urinary tract symptoms (LUTS) related to cystitis. The aim of this study was to assess characteristic troublesome symptoms in female patients with acute uncomplicated cystitis using a symptom questionnaire designed at our clinic. MATERIALS AND METHODS: An routine urinalysis and urine cultures were performed in 310 women who had visited our clinic between January 2005 and June 2006. Of these patients, 172 who had pyuria(mean age, 47.4+/-15.3 years) were screened for major symptoms using the questionnaire. The questionnaire included four categories of symptoms(14 symptoms): LUTS, local symptoms, general symptoms, and pain-related symptoms. The severity of symptoms was rated on a 4-point scale from 0(no symptoms) to 3(severe symptoms). The severity of symptoms was compared with the results of the routine urinalysis and urine cultures. RESULTS: Urine cultures were positive in 107(62.2%) patients. Themost frequent and distressing symptom was dysuria, a pain-related symptom (89.0%, 1.78 points). Frequency was most common among LUTS(71.5%), and unwell was most common among the general symptoms(87.2%). In patients that were positive for urine cultures, the occurrence rate of low abdominal discomfort(81.3%, p=0.038) and irritability(72.9%, p=0.026) were significantly higher. CONCLUSIONS: The questionnaire may be useful to assess duration and relief time of LUTS and to determine the progress and treatment outcomes of acute uncomplicated cystitis. Further studies will be required to investigate the effects of acute uncomplicated cystitis related to LUTS.
Cystitis* ; Dysuria ; Female ; Humans ; Lower Urinary Tract Symptoms ; Questionnaires ; Urinalysis

No abstract available.
Humans ; Lower Urinary Tract Symptoms* ; Prostate* ; Urethral Obstruction*

PURPOSE: The size of prostate increases with age, but there has been few Korean data on the prostate size in the general population. We thereby report the size of prostate with respect to age in Korean men residing in Namhae, Korea. MATERIALS AND METHODS: To determine the prostate size, 1421 men from Namhae, Korea underwent transrectal ultrasonography. Size of the prostate was estimated as a weight by the elliptical method. RESULTS: The mean prostate weight was 33.5 10.6 ml. The relationship between prostate volume and age was statistically significant in 1421 men (Pearson correlation coefficient=0.156, p=0.0001). Also, between the normal group and the groups of men with lower urinary tract symptoms (LUTS), there was significant correlation with age (Pearson correlation coefficient=0.162, p=0.0001), while results were insignificant with size (Pearson correlation coefficient= 0.170, p=0.0001). CONCLUSIONS: Size and rate of growth of the prostate were smaller compared to the Western society, nevertheless, prostate size increased with age. For accurate and reasonable age-specific size of the prostate of Korean male, more community based multicenter study will be needed with more refined measurement techniques such as step-section planimetry for the prostatic volume estimation.
Humans ; Korea ; Lower Urinary Tract Symptoms ; Male ; Prostate* ; Ultrasonography

Stone in the enlarged prostatic utricle is relatively rare and usually secondary to cystic dilatation of the utricle. Irritative lower urinary tract symptoms are the most common presenting complaint. Recently we experienced a enlarged prostatic utricle containing multiple stone and reviewed literature briefly.
Calculi* ; Dilatation ; Lower Urinary Tract Symptoms ; Saccule and Utricle*

OBJECTIVE: To develop the visual uroflow scale (VUS), analyze the relationship of VUS score and index of free uroflowmetry, assess urination function preliminarily and improve the work efficiency in the clinic. METHODS: Male lower urinary tract symptoms (LUTS) patients, who attended the Department of Urology in Peking University People's Hospital from March 2016 to March 2017, were assessed for their urination function according to the Visual Uroflow Scale without help from clinicians before undertaking a free uroflowmetry test. And afterwards, a free uroflowmetry was undertaken, and variables including maximal flow rate (Qmax), the average flow rate (Qave) and voiding volume (VV) was obtained. During the study, 124 cases were collected and 53 cases met the inclusion and exclusion criteria and were included in the study cohort. The Spearman correlation analysis was used for analyzing the correlation of VUS scores with free uroflowmetry variables and age. The validity of VUS was evaluated. RESULTS: Most of the patients could choose the very figure matched with self-condition by first instinct without any help from the clinician. The data were analyzed by Spearman correlation analysis. In the present study, voiding time was positively correlated with the VUS score (correlation coefficient, 0.62, P < 0.05). In the present cohort, the patients chose the third and fourth figures to take longer time to urinate, implying worse LUTS situation. Flow time and VUS scores were positively correlated (correlation coefficient, 0.61, P < 0.05). The patients with higher VUS scores would spend more time on urinate, no matter how long urinary hesitation was. Both Qmax and Qave were negatively correlated with the VUS score (correlation coefficient －0.54, －0.62, P < 0.05). The study illustrated that the VUS score suggested that the Qmax basically and further reflected the urination function. And its relationship to age revealed the decreased urination function of aging male, which had reached a consensus. CONCLUSION Development of VUS has helped the clinician assess the urination function preliminarily at the first time. Patients are assessed for a VUS score before getting surgery or receiving the drug for treatment, and can be re-assessed after. The VUS score can provide an objective quantitative basis to evaluate the treatment efficacy. In addition, considering that it is convenient, timesaving and easy to understand, the VUS is available for follow-up.
Cohort Studies ; Humans ; Lower Urinary Tract Symptoms ; Male ; Urination ; Urodynamics

PURPOSE: The definition of continence after radical prostatectomy has not been established. We examined the continence rate and changes in voiding and storage symptoms after laparoscopic radical prostatectomy(LRP). MATERIALS AND METHODS: Fifty-seven patients were enrolled and followed for more than 12 months after a LRP. Postoperative evaluation of urinary incontinence was performed by interview, and was classified as completely dry, intermittent(occasional dribbling only), using only 1 pad/day, using more than 1 pad/day, and no control. Pre- and post-operative International Prostate Symptom Scores(IPSS) were compared(Total, each criterion, and quality of life, voiding, and storage symptom subscores). RESULTS: Sixty seven percent of patients were completely dry and 17% of patients were classified as intermittent. Those using 1 pad/day, more than 1 pad/day, or no control accounted for 2%, 9%, and 5%, respectively. Pre- and post-operative total IPSS and quality of life scores were not different, but urgency and nocturia scores increased(p<0.05). The voiding subscore decreased and the storage subscore increased after LRP(p<0.05), suggesting aggravation of storage symptoms after LRP. CONCLUSIONS: We need to determine which definition of continence is most clinically useful. It is important to assess lower urinary tract symptoms, especially storage symptoms, as well as urinary incontinence after LRP.
Humans ; Lower Urinary Tract Symptoms ; Nocturia ; Prostate ; Prostatectomy ; Quality of Life ; Urinary Incontinence ; Urinary Tract