1.Impact of High Dose Lorazepam on Seizure Threshold in Catatonia: Experience from a Case Study.
Sujita Kumar KAR ; Saurabh KUMAR ; Amit SINGH
Clinical Psychopharmacology and Neuroscience 2016;14(3):321-321
No abstract available.
Catatonia*
;
Lorazepam*
;
Seizures*
2.A comparison of the acute antiemetic effect of ondansetron with combination of metoclopramide, dexamethasone, lorazepam in patients receiving cisplatin.
Seung Ho BAICK ; Mi Kyung CHA ; Yong Wook CHO ; Do Yeun OH ; Sun Joo KIM
Journal of the Korean Cancer Association 1992;24(5):759-765
No abstract available.
Antiemetics*
;
Cisplatin*
;
Dexamethasone*
;
Humans
;
Lorazepam*
;
Metoclopramide*
;
Ondansetron*
3.Effect of Lorazepam injection on Status Epilepticus.
Journal of the Korean Neurological Association 1983;1(2):10-16
Status epilepticus is a neurological emergency requiring immediate effective care to avoid permanent brain damage or death. There is no single ideal pharmacological agent that can be used for status epilepticus. The author has studied the effect of intravenous lorazepam in the tratment of status epilepticus occurring in eighteen patients. Lorazepam controlled status epilepticus in sixteen (88%) of the eighteen patents, showed no side effect such as depressant action on respiratory and cardiovascular system. Also it seemed that lorazepam acted rapidly and its effect lasted at least for over eight hours. Except a few cases who had had prolonged hangover, the injection seemed to be handy and safe treatment without requiring EKG monitoring and repeated electrolyte check etc. as in dilantinization.
Brain
;
Cardiovascular System
;
Electrocardiography
;
Emergencies
;
Humans
;
Lorazepam*
;
Phenytoin
;
Status Epilepticus*
4.Effect of Lorazepam injection on Status Epilepticus.
Journal of the Korean Neurological Association 1983;1(2):10-16
Status epilepticus is a neurological emergency requiring immediate effective care to avoid permanent brain damage or death. There is no single ideal pharmacological agent that can be used for status epilepticus. The author has studied the effect of intravenous lorazepam in the tratment of status epilepticus occurring in eighteen patients. Lorazepam controlled status epilepticus in sixteen (88%) of the eighteen patents, showed no side effect such as depressant action on respiratory and cardiovascular system. Also it seemed that lorazepam acted rapidly and its effect lasted at least for over eight hours. Except a few cases who had had prolonged hangover, the injection seemed to be handy and safe treatment without requiring EKG monitoring and repeated electrolyte check etc. as in dilantinization.
Brain
;
Cardiovascular System
;
Electrocardiography
;
Emergencies
;
Humans
;
Lorazepam*
;
Phenytoin
;
Status Epilepticus*
5.Reverse Effect of Flumazenil on the Cerebral and Circulatory Functions Suppressed by Lorazepam in Dogs .
Yong Seok OH ; Young Chon WON ; Yong Lak KIM
Korean Journal of Anesthesiology 1991;24(5):916-924
The effects of lorazepam on cerebral function, metabolism, and hemodynamics were studied in eight dogs receiving a general anesthesia with isoflurane(0.5 vo1%)-50% nitrous oxide-oxy-gen. The effects of benzodiazepine antaronist, flumazenil, were also examined. Lorazepam(0.5 mg/kg) administration did decrease mean arterial pressure(MAP) and herat rate(HR). It did significantly decrease cerebral blood flow(CBF)(measured by posterior sagittal sinus outflow method) by 25% of control value(68+/-l3 vs. 51+/-12ml/100gm/min, meanSD) and cereberal metabolic rate for oxygen(CMRO ) by 17% (3.96+/-1.04 vs. 3.30+/-0.92ml/l00gm/min, mean+/-SD). Electroencephalogram(EEG) converted to high amplitude, predominantly theta and delta activity. Intracranial pressure(ICP) increased markedly. Following flumazenil(0.06 mg/kg) administration, HR recovered completely to control level but MAP increased only at 5 min. compared to pre-flumazenil value and returned to pre-flumazenil level. CBF recovered to control level for 15 min. and deereased after 30 min. compared to control level but higher than pre-flumazenil level about 9-15%. CMRO recovered completely to control leveL EEG changed to an awake pattern after fluamzenil administration. It is concluded that lorarepam decreased cerebral function and metabolism and depressed hemodynamic fuction. Benzodiazepine antag- onist, flumazenil, was effective in reversing cerebral and hemodynamic effects, may be in dose related manner.
Anesthesia, General
;
Animals
;
Benzodiazepines
;
Dogs*
;
Electroencephalography
;
Flumazenil*
;
Hemodynamics
;
Lorazepam*
;
Metabolism
6.Use of Lorazepam in Drug-Assisted Interviews: Two Cases of Dissociative Amnesia.
Sang Shin LEE ; Sinhyung PARK ; Si Sung PARK
Psychiatry Investigation 2011;8(4):377-380
Drug-assisted interviews are useful for psychiatric diagnosis and treatment. However, amobarbital, a typical medication used for this purpose, is associated with elevated risk of respiratory depression. Benzodiazepines are good substitutes for amobarbital, with similar therapeutic effects and fewer complications. Although drug-assisted interviews are not widely used, they may be beneficial for selected patients who do not respond to conventional treatments such as supportive psychotherapy or psychopharmacotherapy. We report two cases of dissociative amnesia that were treated using lorazepam-assisted interviews. The use of lorazepam in drug-assisted interviews is effective and safe for resolving dissociative amnesia.
Amnesia
;
Amobarbital
;
Benzodiazepines
;
Humans
;
Lorazepam
;
Mental Disorders
;
Psychotherapy
;
Respiratory Insufficiency
7.Treatment Experiences of High Dose Lorazepam Dependence: Two Case Reports.
Jung Hyun LEE ; Ho Suk SUH ; Ji Woong KIM ; Dong Hwa KIM ; Tae Hoon KIM ; Hong Shick LEE
Korean Journal of Psychopharmacology 2000;11(1):83-87
Drugs of the benzodiazepine family pharmacologically have superior anti-anxiety, sedative, anti-convulsant, and muscle relaxant effect resulting in its popular use not only in psychiatry but in other field of medicine. However, the long term use of benzodiazepines may cause to question the efficacy and may amount to dependence, tolerance, and withdrawal symptoms thus leading to sociologic problems. The treatment strategies of benzodiazepine dependence consist of gradual dosage reduction, the substitution to a long half-life benzodiazepine, and providing psychological support. We present two treatment experiences of high dose lorazepam dependence along with the review of corresponding literature.
Benzodiazepines
;
Half-Life
;
Humans
;
Lorazepam*
;
Substance Withdrawal Syndrome
8.Risperdal Sachet and Oral Lorazepam versus Intramuscular Haloperidol and Lorazepam Injection for Acute Psychotic Symptom in the Elderly Patients with Organic Mental Disorder.
Journal of the Korean Society of Biological Psychiatry 2007;14(2):99-105
OBJECTIVES: The purpose of present study was to investigate the effect, safety and tolerability of risperdal sachet(oral solution) with lorazepam tablet versus intramuscular haloperidol and lorazepam injection for management of acute psychotic symptom in the elderly with organic mental disorder. METHODS: Total 37 patients who have dementia, medical or physical diseases, associated with acute psychotic symptom were randomly assigned to oral treatment with 1mg of risperdal sachet(oral solution) plus 1mg of lorazepam(N=17) or to intramuscular treatment with 2.5mg of haloperidol plus 2mg of lorazepam(N=20). The change of CGI scores was used for the evaluation of efficacy. RESULTS: Mean score improvements at 15, 30, 60, and 120 minutes after treatment were statistically significant at each time point in both groups(p<0.001) and were similar in both groups(p=0.189). CONCLUSION: A single oral dose of risperdal sachet(oral solution) plus lorazepam was as effective and tolerable as parenterally administered haloperidol plus lorazepam for the rapid control of acute psychotic symptom in the elderly with organic mental disorder.
Aged*
;
Delirium
;
Neurocognitive Disorders*
;
Dementia
;
Haloperidol*
;
Humans
;
Lorazepam*
9.Comparison of Clinical Outcomes and Treatment Methods Applying International Guideline in Status Epilepticus.
Hwan Soo KIM ; Sung Koo KIM ; Il Tae HWANG ; Kon Hee LEE
Journal of the Korean Child Neurology Society 2008;16(1):28-35
PURPOSE: Status epilepticus(SE) is a common neurological emergency in childhood. SE is defined as a seizure or series of seizures without recovery of consciousness between seizures lasting at least 30 minutes. We investigated treatment modalities and clinical courses of patients with SE and tried to find out the differences between international standards. METHODS: We reviewed the medical records of 36 cases of SE who visited our hospitals from January 2002 to December 2007. We analyzed age, duration of seizures before and after arrival at hospital, time taken for administration of antiepileptic drugs(AED) and compared them with APLS guideline(3rd edition). RESULTS: There were 32 cases in which lorazepam was used as the first AED and the mean time needed for administration was 4.6+/-6.7minutes. Thirty cases needed a second dose of lorazepam and the mean time needed for administration was 10.2+/-8.2 minutes. Seven patients(21.1%) received inappropriate treatment at the first step and 25 patients(83.3%) and 21 patients(84.0%) at the second and the third step respectively. There were 15 cases in which phenytoin or phenobarbital was used as the second line AED and the mean time needed for administration was 25.8+/-61.8 minutes. CONCLUSION: Early treatment of SE is important in reducing mortality and morbidity associated with SE. In this study we found that a large number of patients were not treated according to the international guideline. Further study is needed to understand the reasons for such differences.
Consciousness
;
Emergencies
;
Humans
;
Lorazepam
;
Medical Records
;
Phenobarbital
;
Phenytoin
;
Resin Cements
;
Seizures
;
Status Epilepticus
10.Clinical Experience of General Anesthesia in a Child with Status Epilepticus Induced by Febrile Convulsion: A case report.
Jun Rho YOON ; Tae Kwan KIM ; Ho Sik MOON ; Si Hyun KIM ; Jin Seo KIM ; Byung Hyun HWANG
Korean Journal of Anesthesiology 2003;45(4):547-551
When continuous seizures are refractory to conventional intravenous anticonvulsant drugs, general anesthesia has been recommended to control status epilepticus. We present the case of a 6-year-old male patient who was admitted for generalized tonic-clonic status epilepticus secondary to febrile convulsion due to an upper respiratory infection. The tonic-clonic status epilepticus was refractory to all anticonvulsant measures and drugs including, phenytoin, phenobarbital, diazepam and lorazepam. After about 32 hours of unsatisfactory seizure activity control, we started general anesthesia for the management of his status epilepticus. After discontinuing general anesthesia, the patient developed a small number of episodes of epilepsia partialis, but seizure activity was well controlled by conventional anticonvulsants. The patient was extubated after three days and was discharged from hospital as cured 12 days after general anesthesia management.
Anesthesia, General*
;
Anticonvulsants
;
Child*
;
Diazepam
;
Humans
;
Isoflurane
;
Lorazepam
;
Male
;
Phenobarbital
;
Phenytoin
;
Seizures
;
Seizures, Febrile*
;
Status Epilepticus*