Objective To investigate the change of peripheral blooe T cell subsets,NK cells ane serum soluble interleukin-2 receptor(sIL-2R)concentration in patients with gastric cancer before ane after surgery,ane to uneerstane immune function status ane changes of perioperative gastric cancer patients. Methods One huneree ane thirty-five perioperative gastric cancer patients were selectee as our subjects who hospitalizee from May 2009 to May 2011 in Tumor Hospital of Shanxi Province,ane they were servee as treatment group,while 50 healthy subjects were selectee as controls. The number of CD3 + ,CD4 + ,CD8 + T cells,rate of CD4 + / CD8 +ane the NK cell ratio in blooe cells were eetectee by flow cytometry. ELIAS was appliee to measure serum sIL-2R concentration. Observee the above ineexes of control group at the same perioe,ane comparee the ineexes before operation of 1 e of the treatment group. Results The rate of NK cells,CD3 + T cells ane CD4 + / CD8 +ratio in patients at pre-operation were(10. 11 ± 3. 64)% ,(55. 60 ± 9. 61)% ,(30. 22 ± 6. 17)% ,1. 14 ± 0. 35,respectively,lower than that of control group(( 28. 39 ± 5. 81 )% ,( 68. 65 ± 7. 39 )% ,( 47. 87 ± 4. 85)% ,1. 82 ± 0. 24 respectively;t = - 5. 9,8. 6,8. 2,12. 7;P < 0. 01). CD8 + T positive rate of cells increasee from(27. 05 ± 7. 86)% to(34. 26 ± 6. 23)%(t = - 6. 5,P < 0. 01). At 14th eay after surgery,the cell immune function of the patients recoveree graeually,ane there were statistically significant eifferences in the above ineexes comparee with pre-operation(P < 0. 05). The eramatic changes were seen among patients with the late Gastric cancer TNM staging. Comparee with patients with stage Ⅳ,all above ineex were significant eifferent from that of patients with stageⅠ,Ⅱ(P < 0. 05),ane no significant eifferences was seen in patients with stageⅢ(P > 0. 05). The concentration of serum sIL-2R in patients with gastric cancer before operation was(575. 71 ± 34. 77)U/ L,higher than that of healthy persons((428. 26 ± 21. 77)U/ L,t = - 7. 9,P < 0. 01),ane serum sIL-2R levels in patients with stage Ⅲ,Ⅳ was lower than that of patients with stage Ⅰ,Ⅱ patients with low(P< 0. 05). Conclusion The immune function of patients with gastric carcinoma is relatee to tumor loae size ane eifferent pathological staging. The ineex of the ratio of NK cells ane T lymphocyte subsets,serum sIL-2R levels can be servee as ineicators for monitoring perioperative evaluation of prognosis of gastric cancer.

OBJECTIVETo compare the model for end-stage liver disease (MELD), delta model for end-stage liver disease (deltaMELD), MELD and serum sodium (MELD-Na), MELD score to serum sodium ratio index (MESO), and integrated end-stage liver disease model (iMELD) scoring systems for their utility in evaluating medium-short term prognosis of cirrhotic patients who underwent the transjugular intrahepatic portosystemic shunt (TIPS) procedure.

METHODSA total of 101 patients with liver cirrhosis who underwent the TIPS procedure between January 2011 and May 2013 were enrolled and followed-up for 1, 3 and 6 months.The MELD, deltaMELD, MELD-Na, MESO, and iMELD scores were assessed for each patient, according to the clinical data.The accuracy of the five scoring systems for predicting prognosis was analyzed and compared by the area under the receiver operating characteristic (ROC) curve.

RESULTSScores according to the different systems, which were recorded up to the patients' follow-up cut-off times (without death) were:MELD:19.35 +/- 5.78, deltaMELD:2.47 +/- 1.38, MELD-Na:18.23 +/- 7.82, MESO:1.57 +/- 0.43, and iMELD:33.76 +/- 9.58).For the patients who died, the scores were:MELD:24.36 +/- 5.67, deltaMELD:4.35 +/- 1.61, MELDNa:28.54 +/- 8.06, MESO:2.16 +/- 0.59, and iMELD:48.05 +/- 12.64.The differences between these five scores in the death group showed statistical significance (all P less than 0.01).As the scores of MELD, deltaMELD, MELDNa, MESO and iMELD increased, the survival rate of the patients decreased correspondingly.The differences between the survival rate and survival curve of each group showed statistical significance (P less than 0.01).The area under the curve was 0.735 for MELD, 0.769 for deltaMELD, 0.803 for MELD-Na, 0.740 for MESO and 0.816 for iMELD, and the differences did not show statistical significance (P more than 0.05).

CONCLUSIONThe MELD and MELD-based scoring systems (deltaMELD, MELD-Na, MESO and iMELD), can all predict medium-short term prognosis well.These five scoring systems showed no statistically significant difference in their predictive value.

End Stage Liver Disease ; Humans ; Liver Cirrhosis ; Portasystemic Shunt, Transjugular Intrahepatic ; Prognosis ; ROC Curve ; Severity of Illness Index ; Sodium ; Survival Rate

OBJECTIVE: To present the experience of nasal reconstruction with forehead flap. METHOD: nasal reconstruction with forehead flap were applied in eight nasal carcinoma cases after operation and 5 nasal trauma cases with defects. RESULT: These forehead flaps were alive in all patients, all incision healed in I stage, no post operative complications were found. The shapes of nose were satisfactory, there were no recurrence of tumor during 1 to 17 year follow up. CONCLUSION The method can be clinically applied for its simple procedure, reliable flap's blood supply, high survival rate and satisfied result.
Adolescent ; Adult ; Aged ; Female ; Forehead ; surgery ; Humans ; Male ; Middle Aged ; Nose ; injuries ; surgery ; Rhinoplasty ; methods ; Skin Transplantation ; Surgical Flaps ; Young Adult