1.Efficacy observation of apapatinib combined with oxaliplatin and tiggio for treatment of advanced gastric cancer
Xiaohong YAN ; Yaning ZHAO ; Hua WANG ; Yi GENG ; Qiao YANG ; Longke DONG ; Yao LIU
Cancer Research and Clinic 2017;29(11):761-764
Objective To investigate the clinical efficacy of apapatinib-targeted therapy combined with oxaliplatin and tiggio for treatment of gastric cancer. Methods A total of 150 patients with advanced gastric cancer were enrolled from March 2015 to March 2017. According to the random number table method, the patients were divided into the study group (apocitinib combined with oxaliplatin+tiggio) and the control group (oxaliplatin + tiggio), 75 cases each. The recent treatment effects and adverse reactions were compared between the two groups. Results The objective response rate (46.7 % vs. 25.3 %) and disease control rate (76.0 % vs.48.0 %)in the study group and the control group were statistically significant(all P <0.05).There were no statistical differences in the incidence of complications such as myelosuppression, digestive tract reaction, fatigue and oral ulcer between the two groups (all P > 0.05). The incidence of complications such as hypertension, proteinuria and hand-foot syndrome in the study group was higher than those in the control group (all P < 0.05), but it was in a state of grade Ⅰ~Ⅱ and tolerance. Conclusion Apotiphene combined with oxaliplatin and tiggio as a chemotherapy regimen for advanced gastric cancer may have a better effect.
2.Curative effect observation of erlotinib plus temozolomide for recurrence/progression in patients with EGFR gene mutation in NSCLC with brain metastases after whole brain radiotherapy
Qiao YANG ; Yao LIU ; Hui QIU ; Yi GENG ; Xiaohong YAN ; Jie HOU ; Cuihua CUI ; Longke DONG
Journal of International Oncology 2019;46(5):257-261
Objective To observe the clinical efficacy and safety of erlotinib plus temozolomide for recurrence/progression patients with epidermal growth factor receptor (EGFR) gene mutation in non-small cell lung cancer (NSCLC) with brain metastases after whole brain radiotherapy.Methods A total of 68 EGFR gene mutation NSCLC patients with brain metastases of intracranial recurrence/progression after whole brain radiotherapy were selected from August 2013 to June 2018 in Baoji Central Hospital of Shaanxi Province and Xintai People's Hospital of Shandong Province.All the patients were randomly divided into erlotinib group and combined treatment group (erlotinib combined with temozolomide) using random number table method.The patients in erlotinib group (34 cases) were treated with oral erlotinib 150 mg/d until progression or unacceptable adverse reaction,and the patients in combined treatment group (34 cases) were given erlotinib and oral temozolomide 150 mg/(m2 · d) for 1-5 day,every 28 days was a cycle,temozolamide for 6 cycles.Comparison was made on curative effects and occurrence condition of adverse reactions between the two groups.Results The overall response rates in the erlotinib group and combined treatment group were 11.8% (4/34)and 32.4% (11/34) respectively,and the disease control rates in the two groups were 35.3% (12/34) and 64.7% (22/34) respectively,with significant differences (x2 =4.191,P =0.041;x2 =5.882,P =0.015).The median progression-free survival in the erlotinib group and combined treatment group were 3.22 months and 5.29 months respectively,and the median overall survival in the two groups were 5.60 months and 7.90 months respectively,with significant differences (x2 =9.269,P =0.002;x2 =11.005,P =0.001).The incidence of nausea and vomiting in combined treatment group was significantly higher than that in erlotinib group [67.6% (23/34) vs.14.7% (5/34)],with a significant difference (x2 =19.671,P < 0.001),but there were no significant differences in the incidences of other adverse reactions (all P > 0.05).The patients in the two groups had no more than grade Ⅲ of adverse reactions.Conclusion The curative effect of erlotinib combined with temozolomide is better in the treatment of recurrence/progression patients with EGFR gene mutation in NSCLC with brain metastases after whole brain radiotherapy,with mild adverse reactions and good patients' tolerance.
3.Efficacy and Safety of Long-acting GLP- 1 Receptor Agonist Semaglutide for Type 2 Diabetes:A Systematic Review
Zhiwei LU ; Hao SUN ; Ying LI ; Longke XIAO ; Yan DONG ; Aina LIU ; Zhenyu ZHAO
China Pharmacy 2019;30(7):969-975
OBJECTIVE: To systematically evaluate therapeutic efficacy and safety of long-acting glucagon like peptide-1 (GLP-1) receptor agonist Semaglutide vs. placebo or other glucose-lowering drugs in the treatment of type 2 diabetes mellitus (T2DM), and to provide evidence-based reference for T2DM in clinic. METHODS: Retrieved from PubMed, Embase, Medline, Cochrane library, randomized controlled trials (RCT) about Semaglutide (trial group) vs. placebo or other glucose-lowering drugs (control group) in the treatment of T2DM were selected during the establishment of database to Sept. 2018. After data extraction and quality evaluation with Cochrane system evaluator manual 5.1.0, Meta-analysis was performed for HbA1c level and compliance rate, fasting plasma glucose (FPG) level, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), body weight pulse frequency level, the incidence of hypoglycemia and gastrointestinal reaction by using Rev Man 5.3 software. RESULTS: A total of 12 RCTs involving 9 966 patients were included. The results of Meta-analysis showed that compared with control group, trial group could effectively decrease the levels of HbA1c [MD=-1.03, 95%CI(-1.22,-0.85), P<0.001] and FPG [MD=-1.14, 95%CI(-1.53,-0.76), P<0.001], increase compliance rate of HbA1c [RD=0.40, 95%CI(0.31,0.49), P<0.001], reduce SBP [MD=-2.61, 95%CI (-3.23, -1.98), P<0.001] and DBP [MD=-0.56, 95%CI (-0.96, -0.16), P=0.006], decrease BMI [MD=-1.25, 95%CI (-1.51, -0.99), P<0.001] and body weight [MD= -3.60, 95%CI(-4.24, -2.96), P<0.001], increase pulse frequency [MD=2.16, 95%CI (1.51, 2.81), P<0.001]. The major adverse drug reactions were gastrointestinal reaction; the incidence of gastrointestinal reaction was higher than control group [RD=0.20, 95%CI(0.15,0.26), P<0.001], but there was no statistical significance in the incidence of hypoglycemia events between 2 groups [RD=0.00, 95%CI(-0.01,0.02), P=0.44]. CONCLUSIONS: Semaglutide can significantly decrease HbA1c, FPG, body weight, blood pressure and increase pulse frequency in T2DM patients, and increase the compliance rate of HbA1c. Although the incidence of gastrointestinal reaction is higher than control group, but the risk of hypoglycemia is not higher, indicating Semaglutide is well tolerated and safe.