1.Some experience of field medical station equipment and materials management.
Shuang HE ; Chaoqun ZHANG ; Yonghe HU ; Longfu ZHOU ; Jian HE ; Kewei XU ; Ben XU
Chinese Journal of Medical Instrumentation 2013;37(6):454-456
The field medical station in military hospital plays an important role in the military logistic system. To better accomplish the duty of medical support mission, the problems of medical equipment and material store house management in the field medical station are discussed. Some targeted suggestions are introduced from daily management and the use of equipment respectively. It can be used as reference for other military hospitals to accomplish different medical support tasks.
Hospitals, Military
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organization & administration
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Military Medicine
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instrumentation
2. Brucine in inducing cell apoptosis of human pancreatic cancer CFPAC-1 cells by regulating the pathway of mitochondrial apoptosis
Longfu TIAN ; Qi ZHANG ; Lihua CUI ; Lei YANG ; Yi ZHOU ; Yu TIAN ; Bo MA
Chinese Journal of Pancreatology 2019;19(6):425-429
Objective:
To investigate the influence of Brucine on cell apoptosis of pancreatic cancer CFPAC-1 cells and the possible mechanism.
Methods:
Brucine in different concentrations were used to treat CFPAC-1 cells. Cell proliferation was determined by MTT assay and cell apoptosis was determined by flow cytometer assay. Mitochondrial membrane potential was examined by JC-1 staining. The protein expression of Bax and Bcl-2 was measured by Western Blot.
Results:
The growth inhibition rates of CFPAC-1 cells after being treated with 0 (control group), 0.4 and 0.8 mmol/L Brucine for 24, 48 and 72 h were 0, (30.23±0.55)%, (40.61±0.15)%, (46.98±1.27)% and(50.17±0.75)%, (61.23±0.91)%, (70.32±0.40)%, increasing with a concentration- and time-dependent increase, which was higher than that in control group; and the differences between either two groups at different time points were statistically significant (
3.Anaplastic lymphoma kinase-positive adenocarcinoma of lung: a cytopathologic analysis.
Ying CHEN ; Lili GAO ; YanLi WANG ; Xian GUI ; Hao ZHANG ; Longfu WANG ; Lianghong GU ; Liqing FENG ; Jiawen WU ; Wentao YANG ; Yiju SONG ; Huan ZENG ; Jing ZHANG ; Qianming BAI ; Xiaoyan ZHOU ; Bo PING ; E-mail: BPING2007@163.COM.
Chinese Journal of Pathology 2015;44(9):628-632
OBJECTIVETo study the cytomorphologic features of anaplastic lymphoma kinase (ALK)-rearranged pulmonary adenocarcinoma.
METHODSThe morphologic features in 153 pulmonary adenocarcinoma cytology specimens encountered during the period from September, 2011 to April, 2015 in Shanghai Cancer Hospital were retrospectively reviewed. Fluorescence in-situ hybridization (FISH) and/or immunohistochemistry (Ventana D5F3) for ALK gene rearrangement were carried out. The samples studied included 34 pleural effusion specimens, 40 endobronchial ultrasound-guided transbronchial needle aspirates (EBUS-TBNA) and 79 fine needle aspirates of palpable masses on body surface.
RESULTSThirty-nine cases (25.5%) of ALK-rearranged samples were identified by FISH and/or immunohistochemistry, including 3 cases diagnosed by FISH and 36 cases by both technologies. The median age of the ALK-positive group was 50 years, significantly younger than that of the ALK-negative group (60 years old, P = 0.002). Only 4 of the ALK-positive patients were smokers, which was significantly less than that of the ALK-negative group (P < 0.01). In ALK-positive group, 3 cases showed cribriform pattern with prominent nucleoli, 3 cases showed cribriform pattern with mucin-rich cells and 8 cases showed extracellular mucus with mucin-rich cells. The above cytomorphologic patterns were significantly less common in ALK-negative tumors (P < 0.01).
CONCLUSIONSALK-rearranged lung adenocarcinoma is associated with certain distinctive morphologic patterns, including cribriform architecture, presence of prominent nucleoli, mucin-rich cells and extracellular mucus, which can be observed in cytology specimens (including conventional smears and cell block sections). These findings, when combined with clinical features, may give clues to detection of ALK-positive cases.
Adenocarcinoma ; genetics ; pathology ; Biopsy, Fine-Needle ; China ; Gene Rearrangement ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lung Neoplasms ; genetics ; pathology ; Receptor Protein-Tyrosine Kinases ; genetics ; Retrospective Studies
4. The usage of comprehensive geriatric assessment in elderly patients with acute myeloid leukemia: a multicenter, prospective study
Qi WU ; Rong FU ; Mingfeng ZHAO ; Yigai MA ; Hao JIANG ; Liangding HU ; Yu JING ; Hui LIU ; Liru WANG ; Li SU ; Yongqing ZHANG ; Chunlin ZHOU ; Yan ZHANG ; Hanyun REN ; Bin JIANG ; Hebing ZHOU ; Lin KANG ; Lu ZHANG ; Daobin ZHOU ; Jian LI
Chinese Journal of Hematology 2019;40(1):35-39
Objective:
To evaluate the feasibility and potential value of comprehensive geriatric assessment (CGA) in elderly (≥60 years) patients with newly diagnosed acute myeloid leukemia (AML) in China.
Methods:
The CGA results of 83 newly diagnosed AML (non-APL) patients from 16 hospitals in Beijing and Tianjin between March 2016 and December 2017 were prospectively collected and analyzed. The clinical data, treatment and follow-up information were also collected.
Results:
Of 83 newly diagnosed elderly AML patients, 81 patients (97.6%) completed all designated CGA assessment. The median number of impaired scales of the CGA assessment in the studied population was 2(0-6). Sixteen patients (19.3%) showed no impairments according to the geriatric assessment scales implem ented by this study. The distributions of impaired scales were as follows: impairment in ADL, 55.4%; IADL impairment, 42.2%; MNA-SF impairment, 48.2%; cognitive impairment, 15.7%; GDS impairment, 31.7%; HCT-CI impairment, 19.5%, respectively. In patients with "good" ECOG (
5.The usage of comprehensive geriatric assessment in elderly patients with acute myeloid leukemia: a multicenter, prospective study.
Qi WU ; Rong FU ; Ming Feng ZHAO ; Yi Gai MA ; Hao JIANG ; Liang ding HU ; Yu JING ; Hui LIU ; Li Ru WANG ; Li SU ; Yong Qing ZHANG ; Chun Lin ZHOU ; Yan ZHANG ; Han Yun REN ; Bin JIANG ; He Bing ZHOU ; Lin KANG ; Lu ZHANG ; Dao Bin ZHOU ; Jian LI
Chinese Journal of Hematology 2019;40(1):35-39
Objective: To evaluate the feasibility and potential value of comprehensive geriatric assessment (CGA) in elderly (≥60 years) patients with newly diagnosed acute myeloid leukemia (AML) in China. Methods: The CGA results of 83 newly diagnosed AML (non-APL) patients from 16 hospitals in Beijing and Tianjin between March 2016 and December 2017 were prospectively collected and analyzed. The clinical data, treatment and follow-up information were also collected. Results: Of 83 newly diagnosed elderly AML patients, 81 patients (97.6%) completed all designated CGA assessment. The median number of impaired scales of the CGA assessment in the studied population was 2(0-6). Sixteen patients (19.3%) showed no impairments according to the geriatric assessment scales implem ented by this study. The distributions of impaired scales were as follows: impairment in ADL, 55.4%; IADL impairment, 42.2%; MNA-SF impairment, 48.2%; cognitive impairment, 15.7%; GDS impairment, 31.7%; HCT-CI impairment, 19.5%, respectively. In patients with "good" ECOG (n=46), the proportion of impairment for each CGA scale ranged from 6.5% to 37.0% and 32 patients (68.9%) had at least one impaired CGA scale. Survival analysis showed that the number of impaired scales of the CGA was significantly correlated with median overall survival (P=0.050). Conclusions: CGA was a tool with feasibility for the comprehensive evaluation in elderly AML patients in China. Combined with age and ECOG, CGA may be more comprehensive in assessing patients' physical condition.
Activities of Daily Living
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Aged
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China
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Geriatric Assessment
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Humans
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Leukemia, Myeloid, Acute
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Prospective Studies