1.The treatment for calcaneus fracture involving talocaneal joint with AO titanium plate
Chinese Journal of Primary Medicine and Pharmacy 2009;16(5):827-828
Objective The treatment of open reduction and internal fixation with AO titanium plate was applied for calcaneus fracture involving talocalcaneal joint. Methods 36 patients were performed with this method, the Bolder angle and Gissane angle of calcaneus were compared before and after operation. The patients were followed up for an average period of 11.2 months. Results All the patients were well healed, the average data of Bolder angle was 22. 31° after operation while - 7. 20° before operation. Conclusion The treatment of open reduction and internal fixation with AO titanium plate is a kind of good method for calcaneus fracture involving talocalcaneal joint. It can not only resume the Bohler angle and Gissane angle, but also resume length, breadth, height of calcaneus. As a result, it can achieve anatomical reduction and patients can do exercises as soon as possible.
2.Application of Biomedical Fibrin Glue in Laparoscopic Hepatectomy
Longbin MA ; Bin LI ; Jin HE ; Xinyuan WANG ; Dawei ZHANG
China Pharmacy 2005;0(17):-
OBJECTIVE:To discuss the application of biomedical fibrin glue in laparoscopic hepatectomy(LH).METHO-DS:40 patients undergoing LH were randomly divided into biomedical fibrin glue group(trial group) and control group:the patients in trial group underwent LH,transection of liver by ultrasound knife,with the transected liver surface sprayed with biomedical fibrin glue guided by laparoscope;the control group underwent routine LH only.The postoperative blood loss and bile leakage were observed by T-tube drainage.RESULTS:In the biomedical fibrin glue group,the operations for all the patients were successful,the postoperative recovery was smooth,the postoperative drainage volume,RBC in the drained fluid,level of hemoglobin and length of hospital stay were all significantly lower than in the control group(P
3.Feasibility of Automatic Treatment Planning in Intensity-modulated Radiotherapy of Nasopharyngeal Carcinoma.
Yinbo HE ; Longbin ZHANG ; Jianghong XIAO ; Baofeng DUAN
Journal of Biomedical Engineering 2015;32(6):1288-1293
Intensity-modulated radiotherapy planning for nasopharyngeal carcinoma is very complex. The quality of plan is often closely linked to the experience of the treatment planner. In this study, 10 nasopharyngeal carcinoma patients at different stages were enrolled. Based on the scripting of Pinnacle 9. 2 treatment planning system, the computer program was used to set the basic parameters and objective parameters of the plans. At last, the nasopharyngeal carcinoma intensity-modulated radiotherapy plans were completed automatically. Then, the automatical and manual intensity-modulated radiotherapy plans were statistically compared and clinically evaluated. The results showed that there were no significant differences between those two kinds of plans with respect to the dosimetry parameters of most targets and organs at risk. The automatical nasopharyngeal carcinoma intensity-modulated radiotherapy plans can meet the requirements of clinical radiotherapy, significantly reduce planning time, and avoid the influence of human factors such as lack of experience to the quality of plan.
Carcinoma
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Feasibility Studies
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Humans
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Nasopharyngeal Neoplasms
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radiotherapy
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Radiometry
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Radiotherapy Dosage
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Radiotherapy Planning, Computer-Assisted
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Radiotherapy, Intensity-Modulated
4.Implantation of ~(125)I Particles plus5-FU Slow-release Particles for Advanced Pancreatic Cancer
Longbin MA ; Bin LI ; Jin HE ; Xinyuan WANG ; Dawei ZHANG ; Jianhui GAN ; Xizhu WANG
China Pharmacy 2005;0(16):-
OBJECTIVE:To observe the clinical effects of interstitial implantation of 125 I particles together with5-FU slow-release particles for advanced pancreatic cancer.METHODS:A total of12patients with advanced pancreatic cancer whose tumors were unsuitable to be resected were implanted with5-FU slow-releasing particles and then 125 I particles.The intensity of radioactive 125 I particles was0.4mCi~0.5mCi,the matched peripheral dose was60Gy~100Gy,and an average of16 125 I particles and1000mg5-FU were used for each patient.RESULTS:Relief of pain was achieved in all the subjects,with the effective rates of odynolysis at91.7%.The tumor size in all the subjects was diminished to some degree,with local control rate at83.3%.1y survival rate was25%.CONCLUSION:Interstitial implantation of 125 I particles and5-FU slow-release particles for advanced pancreatic cancer is simple,safe and effective.
5.Retrospective study on efficacy and safety of the sequential use of a non-bioartificial liver support system in the treatment of acute fatty liver during pregnancy.
Na HE ; Longbin ZHAO ; Yangyang ZHENG ; Shaohua ZHU ; Jing ZHANG ; Na LI ; Lin XIA ; Fang YIN ; Xinmin ZHOU
Chinese Journal of Hepatology 2015;23(10):775-777
6.Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response.
Xuesong LI ; Xiang CHEN ; Longbin ZHENG ; Minghong CHEN ; Yunjia ZHANG ; Ruigong ZHU ; Jiajing CHEN ; Jiaming GU ; Quanwen YIN ; Hong JIANG ; Xuan WU ; Xian JI ; Xin TANG ; Mengdie DONG ; Qingguo LI ; Yuanqing GAO ; Hongshan CHEN
Acta Pharmaceutica Sinica B 2023;13(12):4765-4784
Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis, while the underlying mechanism remains elusive. Here, we report that the non-canonical stimulator of interferon genes (STING)-PKR-like ER kinase (PERK) pathway was significantly activated in both human and mice atherosclerotic arteries. Typically, STING activation leads to the activation of interferon regulatory factor 3 (IRF3) and nuclear factor-kappa B (NF-κB)/p65, thereby facilitating IFN signals and inflammation. In contrast, our study reveals the activated non-canonical STING-PERK pathway increases scaffold protein bromodomain protein 4 (BRD4) expression, which encourages the formation of super-enhancers on the proximal promoter regions of the proinflammatory cytokines, thereby enabling the transactivation of these cytokines by integrating activated IRF3 and NF-κB via a condensation process. Endothelium-specific STING and BRD4 deficiency significantly decreased the plaque area and inflammation. Mechanistically, this pathway is triggered by leaked mitochondrial DNA (mtDNA) via mitochondrial permeability transition pore (mPTP), formed by voltage-dependent anion channel 1 (VDAC1) oligomer interaction with oxidized mtDNA upon cholesterol oxidation stimulation. Especially, compared to macrophages, endothelial STING activation plays a more pronounced role in atherosclerosis. We propose a non-canonical STING-PERK pathway-dependent epigenetic paradigm in atherosclerosis that integrates IRF3, NF-κB and BRD4 in inflammatory responses, which provides emerging therapeutic modalities for vascular endothelial dysfunction.