Aims: Researchers found a wide range of therapeutic properties in Spirulina sp. including as anti-cholesterol or anti-hyperlipidemic agent. In this study, the lipid levels of domestic F. catuswere induced in order to scrutinize the anti-hyperlipidemic effects of local S. platensisLUQS1 strain, specifically at concentrations of 0.5g/day and 1.0 g/day.Methodology and results:Elevation of serum lipid levels viz. total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglycerides (TG) as well as the status of kidney [creatinine (Cr) and blood ureanitrogen (BUN)] were observed in four groups of F. catusfor 45 days. The highest levels for TC, LDL and TG (P<0.05) were recorded in high cholesterol diet group (CD) at day 45 with 291.67±2.87 mg·dL-1, 111.60±9.73 mg·dL-1and 146.33±10.44 mg·dL-1, respectively. HDL levels in Spirulina-treated groups (CA and CAA) were better than normolipidemic group (control, SD group), of which the maximum levels were displayed at day 30 specifically 72.87±6.08 mg·dL-1by cats-fed with high cholesterol diet treated with 0.5 g/day S. platensis LUQS1 (CA group). There were insignificant differences (P>0.05) in the BUN levels; however, the Cr levels in CAA group (day 30 and 45) were slightly out of normal range but did not classify under chronic condition. Conclusion, significance and impact of the study: Alternative treatments on hyperlipidemic cats were rarely reported by researchers and medicinal practitioners. Thus, the findings of this present study provided a genuine knowledge concerning the lipid-lowering effect of S.platensisLUQS1 on the hyperlipidem