Objective To observe the anagesia effectof PCIA (patient-controlled intravenous analgesia)with flurbiprofen anddezocine on obstructivesleep apnea sydrome (OSAS)patients under-going uvula palatopharyngoplasty.Methods Sixty OSAS patients,aged 26-59 years,using PCIA af-ter UPPP were randomly divided to three groups (n=20 each):patients in group FD started the PCIA with flurbiprofen 1 mg/kg+dezocine 0.4 μg/kg+Azasetron in 100 ml saline after surgery, while these in group D with dezocine 0.4μg/kg+Azasetron,group S with sulfentanyl 2μg/kg+Aza-setron (background infusion 2 ml/h,single lose 0.2 ml/h,load doses 5 ml/h,lock time 15 min)VAS scores of 1,2,6,12,24,48 h after surgery and the incidence of nausea,vomiting,drowsiness,pruri-tus,were recorded.Results All group patients showed good pain relieve.There were no significant differences in VAS scores observed in three groups.The side effect incidence for group FD,D and S was 5%,10% and 30%.Conclusion PCIA with flurbiprofen and dezocine can provide good anagesia effect and mild side effects on UPPP patients.