Objective To study the effects of aerobic exercises on platelet function in patients with phase Ⅰ essential hypertension (EH). Methods Low-intensity aerobic exercises therapy was given to 36 patients with phase Ⅰ EH for three months. Changes of their blood pressure, heart rate, platelet aggregation rate (PAGTmax), alpha-granule membrane protein (GMP-140) and mean platelet volume (MPV) werer ecorded and compared to those in 36 normal healthy controls. Results As compared to those in controls,PAGTmax, level of GMP-140 and MPV were all increased in patients with phase Ⅰ EH before exercises therapy(t=15.221, 10. 916 and 16. 401, respectively, all P < 0. 01 ). After exercises therapy, 24-hour mean blood pressure decreased in association with reduction in PAGTmax to (0. 80±0. 05)% from (0. 88±0. 08) % (t=4. 323, P < 0. 05), level of GMP-140 decreased to ( 28±20) μg/L from (57±23 ) μg/L ( t=15.049, P<0.01) and MPV decreased to (9.0±0.9)fl from (9.1±0.9)fl (t=5.518, P <0.05) before it. But, there was no significant difference in these in dicators of platelet function in controls before and after exercise therapy (P>0.05). Conclusions Aerobic exercises therapy could be effective in lowering blood pressure in patients of mild EH with increased platelet activation, as well as inhibition ontheir platelet activation.

Objective To investigate CT and MRI findings of primary hepatic neuroendocrine tumor (PHNET) and the correlation with the pathology.Methods 14 patients with pathologically confirmed PHNET were analyzed retrospectively.All the patients underwent CT and 9 patients underwent MR.The CT and MRI findings were analyzed and the correlation with pathology was evaluated.Results Single lesion was found in 8 cases, and multiple nodular lesions in 5 cases, diffuse nodular lesions of the liver in 1 case.The lesions showed low density on CT images in all patients, and liquid-liquid level was visible in 1 lesion associated with internal bleeding.Contrast-enhanced CT in arterial-phase phase showed nodular or marginal ring enhancement in 13 cases, diffuse enhancement in 1 case, and in portal venous and delayed phases the enhancement of lesion subsequently decreased, compared with surrounding liver parenchyma.MRI showed hypointensity on T1WI and hyperintensity on T2WI, intralesional hemorrhage appeared as hyperintensity on T1WI and hypointensity on T2WI, and the enhancement pattern of MRI was similar to that of CT.With the increase of pathology grade,G1 presented as a single solid nodule,G2 as solid or cystic-solid nodules, and G3 as diffuse nodules or intrahepatic metastasis was found.The lesions showed hyperintensity on DWI.Conclusion CT and MRI can show characteristic appearances of PHNET and its certain histological characteristics.

Objective To explore the value of diffusion-weighted imaging (DWI) on evaluation and prediction of therapeutic outcome in concurrent chemoradiotherapy for cervical squamous carcinoma.Methods 26 cases of cervical squamous carcinoma were examined by MRI before and one month after concurrent chemoradiotherapy.The patients were divided according to tumor response evaluated by Response Evaluation Criteria in Solid Tumors (RECIST).Apparent diffusion coefficient (ADC) values and the receiver operating characteristic (ROC) curve analysis were carried out before and one month after treatment.Results 26 cases had higher mean ADC one month after the concurrent chemoradiotherapy than that before treatment[(1.542±0.189) × 10-3 mm2/s vs (0.898±0.096) × 10-3 mm2/s,P ＜ 0.05].After the treatment,there were 17cases of complete remission (CR) and 9 cases of partial remission (PR).ADC value in PR group was higher than that in CR group [(0.960±0.115) × 10-3 mm2/s vs (0.864±0.067) × 10-3 mm2/s,P ＜ 0.05].ROC curve showed that with 0.927 × 10-3 mm2/s of ADC as threshold to determine the tumor remission,the sensitivity and specificity were 66.7 ％ and 76.5 ％,respectively,and the area under the ROC curve was 0.752 (P ＜ 0.05).At one month after treatment,the tumor volume was decreased in different degrees in CR group and PR group,and the differences of ADC had statistical significance between the two groups [(1.603±0.183) × 10-3 mm2/s vs(1.427±0.146) × 10-3 mm2/s,P＜ 0.05].ROC curve showed that with 1.444 × 10-3 mm2/s of ADC as a threshold for diagnosing tumor residual,the sensitivity and specificity were 76.5 ％ and 55.6 ％ respectively,and the area under the ROC curve was 0.765 (P ＜ 0.05).Conclusions DWI as a useful supplement,can help to precisely evaluate the tumor response after the concurrent chemoradiotherapy and monitor the effects of the treatment.Besides,the ADC before chemoradiotherapy has the predictive value on short-term prognosis in cervical squamous cell carcinoma.

OBJECTIVE:To investigate the use of antibiotics in patients undergoing hemorrhoidectomy in our hospital.METHODS:A total of 120 copies of discharge records of patients undergoing hemorrhoidectomy written by four doctors(30 copies/doctor) between Jan 2006 and Jun 2006 in proctology department were sampled and divided into four groups in accordance with different charging doctors,and a statistical analysis was carried out in respect of the drug consumption sum and medication data of these patients.RESULTS:The irrational use of antibiotics in patients undergoing hemorrhoidectomy in proctology department of our hospital manifested as unclear indications of medication,improper time of drug use,and the prolonged continuous drug use.There were significant differences among four groups in the average drug consumption sum(P

Objectives: To study the differences between sevoflurane and isoflurane in abdomen surgery anesthetized with the target-controlled close-loop anesthesia system.Methods: Forty patients (ASA I-II) were divided into sevoflurane group (n=25) and isoflurane group (n= 15).BIS value of 55 was the control variable index.The target-controlled infusion system of sevoflurane was administered for the maintenance of anesthesia in both groups after intravenous nduction. The BIS values,blood pressures,heart rates and doses of assistant drugs were recorded and analyzed.Results: No statistical difference was observed in BIS、HR and pulse pressure in two groups. During the maintenance of anesthesia, oscillations of BIS and SBP in sevoflurane group were statistically less than those in isoflurane group (P

The medication record of Chinese medicine is not only a complete record of the clinical practice of clinical pharma-cists, but also the essential data for clinical pharmacists to carry out pharmaceutical care. However, at present, there is no unified standard for the medication record of Chinese medicine. Based on the purpose, significance, content and focus, the paper made pre-liminary discussion on the writing of medication record of Chinese medicine, which bulit a preliminary framework for the writing of med-ication record of Chinese medicine.

Objective To investigate compliance and influencing factors of hand hygiene (HH)among health care workers(HCWs).Methods From November 2014 to February 2015,implementation of HH among HCWs in 15 clinical departments in a hospital was investigated through questionnaires,the effect of HH purpose on HH behav-ior of HCWs was analyzed with multivariate logistic regression method.Results A total of 364 HCWs were investi-gated,245 (67.31% )of whom implemented HH well. Univariate analysis revealed that implementation of HH a-mong HCWs of different occupations,education levels,and HH purpose were all significantly different (all P<0. 05). Multivariate logistic regression analysis showed that HH purpose as well as HH compliance were both signifi-cantly different (P= 0.042). Compared with HH purpose of self-protection among HCWs,HCWs with HH pur-pose of cross-infection prevention had better HH behavior (OR,2.17[95% CI,1.29-3.65]).The top five objective factors influencing HCWs'HH implementation were as follows:lack of warm water in winter (70.73% ),heavy workload,had no time (61 .38% ),skin irritation caused by disinfectant or hand sanitizer (54.88% ),without hand dryer (47.56% ),and use disposable gloves (45.12% ).Conclusion On the basis of improving HH facilities,chan-ging HCWs'awareness of HH only for self-protection may be an another way to improve HH compliance among HCWs.

OBJECTIVE To compare the monitoring effect of 2 kinds of B-D testing package.METHODS 2 kinds of testing package around the air vent of first pot sterilizer before antiseptic every day were used preheating 5 min.Start to move the B-D procedure when the band pressure to achieve above 100 kPa with 3 time of pulsation vacuum,inner chamber pressure of 210 kPa,the temperature of 134 ℃ and time of 3.5 min.RESULTS Except the false negative caused by package factor,the testing accurate rate of disposable B-D testing package was 100%.But the testing accurate rate of repeated uses B-D testing package was 90%.CONCLUSIONS The disposable B-D test package may respond promptly the breakdown of sterilizer and avoid the false negative result which the artificial pack factor creates.The test result is accurate.The disposable B-D testing package for examination of autoclave exhaust cold air degree is obviously better than the self-made cotton fabric testing package.

Objective To investigate the change of heart rate variability(HRV) in patients with white coat hypertension (WCH).Methods Participants were classified as essential hypertension (EH) group (n=35),white coat hypertension (WCH) group (n=35),normotension (NT) group (n=35) based on clinic and 24 h ambulatory blood pressure monitoring.The time and frequency-domain measures of HRV were measured by 24 h ambulatory electrocardiographic recording.Results Compared with NT controls,the standard deviation of normal-to-normal intervals (SDNN),rate-mean-square of the difference of successive RR intervals (RMSSD) and high frequence (HF) in the patients with EH and WCH were significantly decreased[SDNN:NT(132.2?21.5)vs EH(115.9?18.9)vs WCH(120.6?17.5)ms;RMSSD:NT(36.8?9.3)vs EH(28.6?8.9)vs WCH(27.5?8.5)ms;HF:NT(206.8?99.7)vs EH(159.5?86.6)vs WCH(161.1?84.5)ms2/Hz;all P0.05).Conclusion These changes in the parameters of HRV showed cardiac autonomic nerve dysfunction in white coat hypertensive patients.

AIM: To observe platelet activation and fibrinolytic activity and evalute the effects of valsartan and amlodipine in elderly patients with essential hypertension. METHODS: Double antibody sandwich ELISA and spectrophotometric assay were used to examine the levels of platelet alpha granule membrane protein (GMP 140), tissue type plasminogen activator (t PA) and its inhibitor (PAI 1) in 57 elderly patients with essential hypertension and 30 normotensives. Valsartan was given in 29 cases (groupⅠ) and amlodipine in 28 cases (group Ⅱ) for 12 weeks. RESULTS: Elevated GMP 140, decreased t PA activity, and elevated PAI 1 activity were detected in the patients, but not in normotensives (P