Objective To analyze clinical efficacy of nimodipine combined with compound danshen solution in treating patients with subarachnoid hemorrhage.Methods 60 patients with acute subarachnoid hemorrhage were randomly divided into observation group and control group from January 2010 to January 2015, 30 cases in each group.Control group was treated with reduce intracranial pressure, symptomatic and supportive treatment, stable pH and electrolyte balance and other conventional treatment, observation group was given conventional therapy basis on the use of nimodipine combined with compound danshen solution, the situation of S100-βin cerebrospinal fluid,clinical efficacy and the incidence of complications of two groups were recorded and analyzed before and after treatment.Results Treatment 5, 7, 14d after S100-βprotein were observed in patients (0.095 ±0.014,0.072 ±0.011,0.022 ±0.010) μg/L, were better than control group (1.120 ±0.012,0.098 ±0.013,0.052 ±0.009) μg/L (P<0.05).Treatment observation group total effective rate was 90.0%,higher than 63.3% of control group(P<0.05).Rebleeding, cerebral ischemia, hydrocephalus and other complications of treatment group were similar to control group, the difference was not significant.Conclusion Clinical efficacy of nimodipine combined with compound danshen solution in treating subarachnoid hemorrhage is effective , precise, which compares with conventional therapy, there is no significant adverse reactions.It can significantly improve the cure rate in patients with subarachnoid hemorrhage , reducing mortality, and it is worthy of further research and applications.