1.Effect of HQSM on CK, LDH and AST in Serum of Myocardial Ischemia Rats
Guiyuan LV ; Suhong CHEN ; Liwen LI
Journal of Zhejiang Chinese Medical University 2006;0(02):-
[Objective] To observe effects of HQSM on CK, LDH and AST activity in serum of acute myocardial ischemia rats caused by injecting pituitrin.[Method] SD rats were divided into several groups at random: normal control group,model control group, three HQSM groups(210mg/kg,150mg/kg,105mg/kg), positive control group(Huangqi Shengmaiyin and Diao Xinxuekang).The rats were treated with respective drugs by ig for 30 days, and pituitrin was injected respectively by caudal vein 1h after administering at the 29th and 30th days.Blood serum was taken out to determinate the activity of CK, LDH and AST at 1h and 24h after the last injection. [Result] The activity of LDH and AST in serum increased at 1h after injecting pituitrin, the activity of CK in serum increased,meanwhile LDH and AST was still higher than normal control group at 24h. HQSM could decrease the activity of CK and AST(P
2.Roles of the chest pain rapid response system in treatment of patients with acute ST-elevated myocardial infarction
Zhengde LU ; Jianting GAN ; Jun YUAN ; Guangma XU ; Ling LIU ; Ying SHI ; Ruikai ZHU ; Yijun LU ; Liwen LV ; Yingzhong LIN
Chongqing Medicine 2017;46(34):4790-4793
Objective To investigate the effects of rapid response system of chest pain on the short-term and long-term prognosis of patients with acute ST segment elevation myocardial infarction (STEMI).Methods Referring to the international association of chest pain centers,the chest pain center was established in this hospital,and the corresponding management system and treatment process were worked out.A total of 374 acute STEMI patients who were recruited as the observation group were admitted to this hospital after the establishment of the chest pain center (December 2014 to June 2016),and 250 STEMI patients admitted before the establishment of the chest pain center (January 2012 to December 2012) were recruited as control group.Patients in observation group were treated in the chest pain center,and those in control groupreceived conventional treatment.The general situation,basic diseases,the finishing time of the first electrocardiogram(ECG),the time of door-to balloon expansion(D2B),the time of hospital stay,the average hospitalization expenses,in-hospital cardiac events and in-6-month cardiac events were compared between the two groups.All patients were followed up for 1 years,left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter (LVEDD),left ventricular aneurysm,B type natriuretic peptide (pro-BNP),serum creatinine (Scr),C-reactive protein (CRP) levels and adverse cardiac events (heart failure,death,readmission rate etc.)were compared between two groups.Results Compared with the control group,the average completion time of the first electrocardiogram in the observation group was shortened (P=0.001),the time of entry balloon dilatation,the time of hospital stay,the average hospitalization expenses were less than that of the control group (P<0.05),the adverse cardiac events (hospital death and heart failure) were lower in the observation group than in the control group (P<0.05).After 6 months of follow-up,LVEF was significantly higher in the observation group than in the control group (P<0.05).the levels of LVEDD,pro-BNP,CRP and adverse cardiac events in the observation group were significantly lower than those in the control group (P<0.05),there was no significant difference in the formation rate of ventricular aneurysm and Scr between the observation group and the control group (P>0.05).After 1 year of follow-up,LVEF was still higher in the observation group than in the control group (P<0.05).The incidence of LVEDD,pro-BNP,CREA,CRP,left ventricular aneurysm formation rate,the incidence of adverse cardiac events were lower in the observation group than in the control group (P<0.05).Conclusion The establishment of rapid response system of chest pain treatment not only effectively shortenthe treatment time of STEMI patients,improve the treatment efficiency,shorten the hospital stay,reduce the cost of hospitalization,but also improve the quality of life and disease prognosis.
3.METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth.
Mengyue LV ; Dan CAO ; Liwen ZHANG ; Chi HU ; Shukai LI ; Panrui ZHANG ; Lianbang ZHU ; Xiao YI ; Chaoliang LI ; Alin YANG ; Zhentao YANG ; Yi ZHU ; Kaiguang ZHANG ; Wen PAN
Protein & Cell 2021;12(12):965-970
4.Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia.
Liansheng ZHAO ; Huijuan WANG ; Yamin ZHANG ; Jinxue WEI ; Peiyan NI ; Hongyan REN ; Gang LI ; Qiang WANG ; Gavin P REYNOLDS ; Weihua YUE ; Wei DENG ; Hao YAN ; Liwen TAN ; Qi CHEN ; Guigang YANG ; Tianlan LU ; Lifang WANG ; Fuquan ZHANG ; Jianli YANG ; Keqing LI ; Luxian LV ; Qingrong TAN ; Yinfei LI ; Hua YU ; Hongyan ZHANG ; Xin MA ; Fude YANG ; Lingjiang LI ; Chuanyue WANG ; Huiyao WANG ; Xiaojing LI ; Wanjun GUO ; Xun HU ; Yang TIAN ; Xiaohong MA ; Jeremy COID ; Dai ZHANG ; Chao CHEN ; Tao LI ; Chinese Antipsychotics Pharmacogenomics Consortium
Neuroscience Bulletin 2019;35(6):1102-1105