No abstract available.
Animals ; Liver Regeneration* ; Liver Transplantation* ; Liver* ; Rats*

Liver ; metabolism ; Liver Regeneration ; Signal Transduction

No abstract available.
Animals ; Jaundice, Obstructive* ; Liver Regeneration* ; Liver* ; Rats*

A retrospective study on 17 patients with the hepatic fasciola hepatica infection with the positive serum diagnosis was carried out. The CT scanner and MRI were implemented to determine the position, evaluate the lesion and monitor the progress and specific signs of the disease. In the CT scanner image, the sound intensity in the fasciola hepatica located position was reduced, the lesion usually concentrated. In the MRI, in the phase of abscess, the sign intensity of lesion was low (higher than T1W and lower than T2W), moderate lesion occurred in septal an wall.
Liver ; Liver Regeneration ; Magnetic Resonance Imaging

Hepatitis ; metabolism ; pathology ; Humans ; Liver Regeneration

It was known that the regenerating liver cytosol accelerated liver regeneration, whereas normal liver cytosol inhibited it during first 28 hours, but promoted it later by the thymidine incorporation test. In experiments, Sprague-Dawley male rats were divided into 3 experimental groups (A, B and C) which had 10 rats in each. Also, each group was equally subdivided into 2 subgroups such as A-8 and A-28 in the A group, B-8 and B-28 in the B group and C-8 and C-28 in the C group. All groups were partially hepatectomized equally. The remnant livers were procured at 8 hours in the 3 subgroups A-8, B-8 and C-8 and at 28 hours in the other 3 subgroups A-28, B-28 and C-28. Another experiment was performed in 10 rats under the same partial hepatectomy to get the average weight of the remnant liver. These data could be taken as the initial weight of the remnant liver in the above experimental animals. The normal saline, normal liver cytosol extract and regenerating liver cytosol extract were injected intraperitoneally after the partial hepatectomies, 4 ml of in the A, B, and C groups, respectively. Since specific structural changes might precede demonstrable functional alterations, morphometric measurements were done in the histological specimens of the 3 subgroups A-8, B-8, and C-8. The remnant livers, obtained in all six subgroups, were weighed to calculate the regeneration rates. The overall results are as follows : 1) The liver regeneration rates in the six subgroups were 4.1% in A-8, 3.8% in B-8, 4.3% in C-8, 28.4% in A-28, 16.7% in B-28, and 32.8% in C-28. 2) The morphometric study showed that the nucleus/cytoplasm ratios in the three subgroups were 0.1389 in A-8, 0.2048 in B-8, and 0.3705 in C-8. These results mean that regenerating liver cytosol extract promotes liver regeneration and that normal liver cytosol extract inhibits it during first 28 hours after a partial hepatectomy, but promotes cell division for subsequent regeneration.
Animals ; Cell Division ; Cytosol* ; Hepatectomy* ; Humans ; Liver Regeneration* ; Liver* ; Male ; Rats* ; Rats, Sprague-Dawley ; Regeneration ; Thymidine

Hepatectomy plays a pivotal role in the management of primary and secondary malignancies of the liver, and offers a curative option for the patient. Postoperative liver failure is a severe complication of liver resection, particularly for patients with underlying liver disease. Portal vein embolization (PVE) is a well-established preoperative technique that redirects blood flow to the anticipated remaining liver after resection in an effort to improve the functional hepatic reserve. PVE has improved the safety of hepatectomy and has extended surgical candidacy to patients who previously would have been ineligible for resection because of insufficient remnant liver volume. This article reviews the following aspects of PVE; indications, contraindications, liver volumetry, approaches, embolization agents, recent outcomes data, and areas of active research including adjunctive therapies and temporary PVE.
Hepatectomy ; Humans ; Liver ; Liver Diseases ; Liver Failure ; Liver Neoplasms ; Liver Regeneration ; Portal Vein

Animals ; Endothelial Cells ; cytology ; Hepatocytes ; cytology ; Humans ; Liver Regeneration

OBJECTIVETo discuss the clinicopathological characteristics and differential diagnosis of nodular regenerative hyperplasia of the liver (NRH).

METHODS9 cases of NRH were collected and their clinical and pathological features were reviewed.

RESULTSNRH is an important cause of non-cirrhotic portal hypertension which is frequently associated with autoimmune disease, malignant tumors and administration of certain drugs. Clinically NRH presents portal hypertension, but with almost normal liver function. Pathological examinations found diffuse nodules of hyperplastic hepatocytes in liver without fibrous septa in between. The obliteration of portal veins are frequently seen. This suggests that ischemia caused by alteration of portal veins may play an important role in the development of nodular regenerative hyperplasia of the liver.

CONCLUSIONHistopathology of NRH is characteristic and it should be differentiated from cirrhosis, focal nodular hyperplasia and hepatocellular adenoma.

Adult ; Female ; Humans ; Hyperplasia ; pathology ; Liver ; pathology ; Liver Diseases ; pathology ; Liver Regeneration ; Male ; Middle Aged

Insulin is well known to have a hepatotrophic effect, but exogenous insulin has a negative effect on liver regeneration because it decreases the level of endogenous insulin. Howerver intraportal exogenous insulin will have some differences. This study was set up to analyse the effect of portal insulin via intraperitoneal route on liver regeneration in rats which have a normal pancreas with or without liver cirrhosis after partial hepatectomy. Beforehand, insulin levels of the portal blood at the time intervals of 0, 30, 60, 120, and 240 minutes after intraperitoneal injection of insulin were measured and compared with those after subcutaneous injection. The results were: 1.5, 140.9, 58.6, 20.4, 14.3 g/ml in intraperitoneal group(n=14) and 1.5, 22.3, 27.1, 32.4, 29.1 g/ml in subcutaneous group(n=14). Intraperitoneally injected insulin was absorbed more rapidly than subcutaneously injected insulin. Thirty nine rats with normal liver were divided into 5 groups A(n=8): intraperitoneal saline, B(n=9): intraperitoneal insulin 2 IU/Kg, C(n=7): subcutaneuos insulin 2 IU/Kg, D(n=7): intraperitoneal insulin 5 IU/Kg, E(n=8): subcutaneous insulin 5 IU/Kg. They were all 2/3 partial hepatectomized and remnant livers were obtained after 24 hours after hepatectomy. Ninety minutes before sacrifice, 100 Ci,H3-thymidine was injected intraperitoneally and their C.P.M./ g of DNA was measured and compared with each other groups. The same procedures were done with another twenty seven rats with liver cirrhosis (A'(n=5), B'(n=6), C'(n=6), D'(n=5), E'(n=5)) which was induced by oral ingestion of CCl4 for 12 weeks. The results were: 38.29, 25.77, 14.37, 34.04, 23.83 C.P.M./ g in normal rat group and 23.76, 8.11, 10.89, 8.80, 12.22 C.P.M./ g. In normal rat, the C.P.M.'s of intraperitoneal groups were higher than those of subcutaneous group and the difference was statistically significant between A and C group (p<0.05). In cirrhotic group, there were not any significant differences between any two groups. It can be concluded that exogenous insulin has an inhibitory effect on liver regeneration. But intraperitoneal insulin exerts less inhibitory effect on liver regeneration than subcutaneous insulin because intraportal insulin is more potent in liver regeneration and has less negative feed back on endogenous insulin than systemic insulin.
Animals ; DNA ; Eating ; Hepatectomy ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Insulin* ; Liver Cirrhosis ; Liver Regeneration* ; Liver* ; Pancreas ; Rats*