1.Current status of liver diseases in Korea: Hepatocellular carcinoma.
The Korean Journal of Hepatology 2009;15(Suppl 6):S50-S59
Primary liver cancer, most of which is hepatocellular carcinoma (HCC), is the third common leading cancer in Korea. During the last two decades, the incidence rate of primary liver cancer has shown a modest decrease, but its mortality rate has slightly increased. The incidence of HCC, according to age, peaks in the late sixth decade in men and in the early seventh decade in women. Hepatitis B virus (HBV) is the most important risk factor, which represents approximately 70% of all HCC, and hepatitis C virus (HCV) and alcohol are the next in order of major risk factors for the development of HCC in Korea. HBV-associated HCC occurs 10 years earlier than HCV-associated HCC due to a more prolonged exposure to HBV, which is vertically transmitted almost from HBsAg-positive mother in HBV-endemic area. National Cancer Control Institute, which was reorganized in 2005, is now working for several national projects such as National Cancer Registration Program, National R&D Program for Cancer Control and National Cancer Screening Program. International collaboration for the clinico-epidemiologic research would be needed to provide the specific measures for managing HCC in diverse etiologic situations. Finally, the mechanisms of hepatitis virus-associated hepatocellular carcinogenesis might be clarified to provide insights into the advanced therapeutic and preventive approaches for HCC in Korea, where the majority of HCC originate from chronic HBV and HCV infections.
*Carcinoma, Hepatocellular/diagnosis/epidemiology/etiology/therapy
;
Humans
;
Incidence
;
Korea/epidemiology
;
*Liver Neoplasms/diagnosis/epidemiology/etiology/therapy
2.Current status of liver diseases in Korea: Hepatocellular carcinoma.
The Korean Journal of Hepatology 2009;15(Suppl 6):S50-S59
Primary liver cancer, most of which is hepatocellular carcinoma (HCC), is the third common leading cancer in Korea. During the last two decades, the incidence rate of primary liver cancer has shown a modest decrease, but its mortality rate has slightly increased. The incidence of HCC, according to age, peaks in the late sixth decade in men and in the early seventh decade in women. Hepatitis B virus (HBV) is the most important risk factor, which represents approximately 70% of all HCC, and hepatitis C virus (HCV) and alcohol are the next in order of major risk factors for the development of HCC in Korea. HBV-associated HCC occurs 10 years earlier than HCV-associated HCC due to a more prolonged exposure to HBV, which is vertically transmitted almost from HBsAg-positive mother in HBV-endemic area. National Cancer Control Institute, which was reorganized in 2005, is now working for several national projects such as National Cancer Registration Program, National R&D Program for Cancer Control and National Cancer Screening Program. International collaboration for the clinico-epidemiologic research would be needed to provide the specific measures for managing HCC in diverse etiologic situations. Finally, the mechanisms of hepatitis virus-associated hepatocellular carcinogenesis might be clarified to provide insights into the advanced therapeutic and preventive approaches for HCC in Korea, where the majority of HCC originate from chronic HBV and HCV infections.
*Carcinoma, Hepatocellular/diagnosis/epidemiology/etiology/therapy
;
Humans
;
Incidence
;
Korea/epidemiology
;
*Liver Neoplasms/diagnosis/epidemiology/etiology/therapy
3.Liver Transplantation for Hepatocellular Carcinoma.
The Korean Journal of Hepatology 2006;12(4):493-506
Since the hepatocellular carcinoma (HCC) develops in cirrhotic liver and is often multicentric, liver transplantation (LT) seems to be a rational approach for the treatment of HCC. Current selection criteria of LT for HCC are Milan criteria (single nodule < or = 5 cm , or < or = 3 nodules and
4.A Case of Hepaticoduodenal Fistula Development after Transarterial Chemoembolization in Patient with Hepatocellular Carcinoma.
Yoon Hea PARK ; Se Hun KANG ; Seung Up KIM ; Do Young KIM ; Jun Yong PARK ; Sang Hoon AHN ; Kwang Hyub HAN ; Chae Yoon CHON
The Korean Journal of Gastroenterology 2011;58(3):149-152
Transarterial chemoembolization (TACE) is recommended as one of the first line therapy for unresectable hepatocellular carcinoma (HCC). Rupture of HCC following TACE is a rare and potentially fatal complication. We report a case of hepaticoduodenal fistula with ruptured HCC and liver abscess complicated by TACE. A 52-year-old male was treated by TACE three times, followed by radiation therapy and systemic chemotherapy. 30 days after the last TACE, right upper quadrant pain of abdomen was developed. About 1 month later, computed tomography of abdomen showed ruptured HCC with debris containing liver abscess and hepaticoduodenal fistula. Esophagogastroduodenoscopy revealed hepaticoduodenal fistula and hepatic parenchyme covered with exudate. The patient was managed with supportive care, but the hepaticoduodenal fistula persisted.
Carcinoma, Hepatocellular/radiotherapy/*therapy
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Chemoembolization, Therapeutic/*adverse effects
;
Endoscopy, Digestive System
;
Gastric Fistula/*etiology
;
Humans
;
Liver Abscess/etiology
;
Liver Diseases/*etiology
;
Liver Neoplasms/radiotherapy/*therapy
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Male
;
Middle Aged
;
Rupture, Spontaneous/etiology
;
Tomography, X-Ray Computed
5.Prevention of liver cancer: basic and clinical aspects.
Experimental & Molecular Medicine 2002;34(5):319-325
Cancer prevention is a challenging project both in the basic and clinical medicine. In particular, prevention of liver cancer is the most urgent task in countries where the incidence of hepatitis virus-related liver cancer is rising. As reviewed in this article, liver cancer is going to be the first cancer that will be actually prevented by primary and secondary interventions. Even the improvement of absolute survival of the patients can be expected by successful prevention, as already demonstrated in a few clinical trials. Thus, prevention of liver cancer is promising to provide not only cost-effectiveness by morbidity reduction but also cost-benefit by mortality improvement.
Animals
;
Chemoprevention
;
Hepatitis B/complications/drug therapy
;
Human
;
Liver Neoplasms/etiology/*prevention & control
;
Retinoids/*therapeutic use
7.Update hepatology in 2008.
Chinese Journal of Hepatology 2009;17(1):1-4
Carcinoma, Hepatocellular
;
diagnosis
;
therapy
;
Gastroenterology
;
trends
;
Hepatitis, Viral, Human
;
diagnosis
;
therapy
;
Humans
;
Liver Cirrhosis
;
diagnosis
;
therapy
;
Liver Diseases
;
diagnosis
;
therapy
;
Liver Failure, Acute
;
etiology
;
therapy
;
Liver Neoplasms
;
diagnosis
;
therapy
;
Retrospective Studies
8.Diagnosis and treatment of de novo malignancy after liver transplantation.
Zhi-Jun ZHU ; Lin LI ; Ya-Min ZHANG
Chinese Journal of Oncology 2007;29(3):237-238
Adult
;
Antiviral Agents
;
therapeutic use
;
Colonic Neoplasms
;
diagnosis
;
etiology
;
therapy
;
Cyclosporine
;
adverse effects
;
Esophageal Neoplasms
;
diagnosis
;
etiology
;
therapy
;
Female
;
Ganciclovir
;
therapeutic use
;
Humans
;
Immunosuppression
;
adverse effects
;
Immunosuppressive Agents
;
adverse effects
;
Liver Neoplasms
;
diagnosis
;
etiology
;
therapy
;
Liver Transplantation
;
adverse effects
;
Lymphoproliferative Disorders
;
diagnosis
;
etiology
;
therapy
;
Middle Aged
;
Pharyngeal Neoplasms
;
diagnosis
;
etiology
;
therapy
;
Survival Analysis
;
Tacrolimus
;
adverse effects
;
Time Factors
9.Clinical analysis of the peri-operative complications following percutaneous transhepatic biliary drainage or stent implantation.
Ping YU ; Ding-ke DAI ; Xiao-jun QIAN
Chinese Journal of Oncology 2009;31(12):923-924
Adult
;
Aged
;
Aged, 80 and over
;
Biliary Tract Neoplasms
;
complications
;
Cholangitis
;
etiology
;
Cholestasis
;
etiology
;
therapy
;
Drainage
;
adverse effects
;
Female
;
Hepatic Encephalopathy
;
etiology
;
Humans
;
Intraoperative Period
;
Jaundice, Obstructive
;
etiology
;
therapy
;
Liver Neoplasms
;
complications
;
Male
;
Middle Aged
;
Pancreatitis
;
etiology
;
Stents
;
adverse effects
10.A Case Series of Liver Abscess Formation after Transcatheter Arterial Chemoembolization for Hepatic Tumors.
Wei SUN ; Fei XU ; Xiao LI ; Chen-Rui LI
Chinese Medical Journal 2017;130(11):1314-1319
BACKGROUNDLiver abscess is a serious complication following transcatheter arterial chemoembolization (TACE). Much attention has been paid to this condition as it may interfere with the treatment process and result in a poor prognosis of the patient. This study aimed to analyze the causes of liver abscess, a complication, after TACE for hepatic tumors and to summarize management approaches.
METHODSFrom June 2012 to June 2014, of 1480 consecutive patients who underwent TACE at our hospital, five patients developed liver abscess after TACE procedures for hepatic tumors. Of the five patients, each receiving conventional TACE, one underwent three sessions, two underwent two sessions, and the remaining two underwent one session of TACE. Demographic and clinical characteristics, together with management approaches and prognosis, were collected through a review of medical records.
RESULTSThese five patients were confirmed to have post-TACE liver abscess through clinical manifestations, laboratory, and imaging tests. After percutaneous drainage and anti-inflammatory treatments, the symptoms present in four patients with liver abscess significantly improved as evidenced by shrinkage or disappearance of the abscess cavity, and the patients recovered completely after sufficient drainage. The remaining patient experienced recurrent symptoms and abdominal abscess, achieved no significant improvement after treatment, and eventually died of severe infection and multiple organ failures.
CONCLUSIONSTACE must be implemented with extreme caution to avoid liver abscess. An effective management relies on an early diagnosis, prompt use of sufficient doses of appropriate antibiotics, and active implementation of abscess incision, drainage, and aspiration.
Adult ; Aged ; Carcinoma, Hepatocellular ; therapy ; Chemoembolization, Therapeutic ; adverse effects ; Humans ; Liver ; pathology ; Liver Abscess ; diagnosis ; etiology ; Liver Neoplasms ; therapy ; Male ; Middle Aged ; Retrospective Studies