1.Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease.
Moon Young KIM ; Soon Koo BAIK
The Korean Journal of Hepatology 2008;14(1):1-3
No abstract available.
Carotid Arteries/pathology/ultrasonography
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Carotid Artery Diseases/diagnosis/*etiology
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Diabetes Mellitus, Type 2/complications/diagnosis
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Fatty Liver/*complications/diagnosis/ultrasonography
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Humans
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Metabolic Syndrome X/complications/diagnosis
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Obesity/complications/diagnosis
;
Risk Factors
2.Comparison of Transient Elastography and Hepatic Fibrosis Assessed by Histology in Chronic Liver Disease.
Min Kyu JUNG ; Han Jin CHO ; Ho Chul LEE ; Kwan Sik PARK ; Eun Hee SEO ; Sung Woo JEON ; Chang Min CHO ; Won Young TAK ; Sung Kook KIM ; Yong Hwan CHOI ; Young Oh KWEON
The Korean Journal of Gastroenterology 2008;51(4):241-247
BACKGROUND/AIMS: Transient elastography (Fibroscan, Echosens, France) is a new, simple, and non-invasive method to assess the degree of hepatic fibrosis by measuring liver stiffness. Recent reports have shown that liver stiffness measurement using Fibroscan allowed accurate prediction of hepatic fibrosis in patient with chronic hepatitis C. The aim of this study was to evaluate accuracy of Fibroscan for the detection of hepatic fibrosis in Korea with various etiologies of chronic liver disease by comparison with fibrosis assessed by histologic examination. METHODS: Fifty-four patients with chronic liver diseases, which were histologically confirmed within recent 6 months were enrolled. Etiologies were HBV, HCV infection, autoimmune hepatitis, and non alcoholic steatohepatitis. Hepatic fibrosis was graded on the basis of standard guideline proposed by the Korean Study Group for the Pathology of Digestive Diseases. RESULTS: Fibroscan values were significantly higher in F3 (16.96 kPa) and F4 (19.86 kPa) than others (p=0.003). Liver stiffness measurement was significantly correlated to the fibrosis stage (r=0.614, p<0.0001). CONCLUSIONS: Liver stiffness measurement by Fibroscan is a promising method for the assessment of hepatic fibrosis in chronic liver disease because it accompanies no complication.
Adult
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Aged
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Biological Markers/blood
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Chronic Disease
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Elasticity
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Elasticity Imaging Techniques/*methods
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Humans
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Liver Cirrhosis/diagnosis/etiology/*ultrasonography
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Liver Diseases/complications/pathology/*ultrasonography
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Male
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Middle Aged
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Predictive Value of Tests
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ROC Curve
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Regression Analysis
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Sensitivity and Specificity
3.Management Strategy for Congenital Choledochal Cyst with Co-existing Intrahepatic Dilation and Aberrant Bile Duct As Well As Other Complicated Biliary Anomalies.
Qian DONG ; Buxian JIANG ; Hong ZHANG ; Zhong JIANG ; Hongting LU ; Chuanmin YANG ; Yu CHENG ; Xiwei HAO
Yonsei Medical Journal 2006;47(6):826-832
The purpose of this study was to investigate and discuss imaging methods and management strategies for congenital choledochal cyst with co-existing intrahepatic dilation and aberrant bile duct as well as other complicated biliary anomalies. In this study we reviewed and analyzed 72 patients with congenital choledochal cyst, ranging in age from 15 days to 12 years old and who were seen at our hospital during the past 12 years, from January 1993 to October 2005. The image manifestation and clinical significance of patients with co- xisting intrahepatic biliary dilation and aberrant bile duct were carefully examined during operation via MRCP, cholangiography and choledochoscope. Twenty-two cases (30.1%) presented with intrahepatic bile duct dilation and 12 of these were of the cystic type. That is, the orifice of the dilated intrahepatic tract that converged into the common hepatic duct showed membrane or septum-like stenosis. In 10 cases the dilation tapered off from the porta hepatis to the initiating terminals of the intra-hepatic bile ducts and was not accompanied by stenosis. An aberrant bile duct was observed in 2 of the cases. In 3 cases, the right and left hepatic ducts converged at the choledochal cyst. In conclusion, the imaging methods for intrahepatic bile duct dilation possess important clinical significance. Further, for hepatojejunostomy with radical excision of a choledochal cyst, additional operative procedures for intrahepatic stenosis, possible bile duct malformation and pancreaticobiliary common duct calculi can potentially reduce postoperative complications.
Tomography, X-Ray Computed
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Postoperative Complications/ultrasonography
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Male
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Liver Diseases/complications/*radiography/surgery
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Infant, Newborn
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Infant
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Humans
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Female
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Choledochal Cyst/complications/*radiography/surgery
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Cholangiography
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Child, Preschool
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Child
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Bile Ducts/*abnormalities/pathology/surgery
4.Management Strategy for Congenital Choledochal Cyst with Co-existing Intrahepatic Dilation and Aberrant Bile Duct As Well As Other Complicated Biliary Anomalies.
Qian DONG ; Buxian JIANG ; Hong ZHANG ; Zhong JIANG ; Hongting LU ; Chuanmin YANG ; Yu CHENG ; Xiwei HAO
Yonsei Medical Journal 2006;47(6):826-832
The purpose of this study was to investigate and discuss imaging methods and management strategies for congenital choledochal cyst with co-existing intrahepatic dilation and aberrant bile duct as well as other complicated biliary anomalies. In this study we reviewed and analyzed 72 patients with congenital choledochal cyst, ranging in age from 15 days to 12 years old and who were seen at our hospital during the past 12 years, from January 1993 to October 2005. The image manifestation and clinical significance of patients with co- xisting intrahepatic biliary dilation and aberrant bile duct were carefully examined during operation via MRCP, cholangiography and choledochoscope. Twenty-two cases (30.1%) presented with intrahepatic bile duct dilation and 12 of these were of the cystic type. That is, the orifice of the dilated intrahepatic tract that converged into the common hepatic duct showed membrane or septum-like stenosis. In 10 cases the dilation tapered off from the porta hepatis to the initiating terminals of the intra-hepatic bile ducts and was not accompanied by stenosis. An aberrant bile duct was observed in 2 of the cases. In 3 cases, the right and left hepatic ducts converged at the choledochal cyst. In conclusion, the imaging methods for intrahepatic bile duct dilation possess important clinical significance. Further, for hepatojejunostomy with radical excision of a choledochal cyst, additional operative procedures for intrahepatic stenosis, possible bile duct malformation and pancreaticobiliary common duct calculi can potentially reduce postoperative complications.
Tomography, X-Ray Computed
;
Postoperative Complications/ultrasonography
;
Male
;
Liver Diseases/complications/*radiography/surgery
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Infant, Newborn
;
Infant
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Humans
;
Female
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Choledochal Cyst/complications/*radiography/surgery
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Cholangiography
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Child, Preschool
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Child
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Bile Ducts/*abnormalities/pathology/surgery
5.Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease; Relation of non-alcoholic fatty liver disease to carotid atherosclerosis.
Su Yeon CHOI ; Donghee KIM ; Jin Hwa KANG ; Min Jung PARK ; Young Sun KIM ; Seon Hee LIM ; Chung Hyeon KIM ; Hyo Suk LEE
The Korean Journal of Hepatology 2008;14(1):77-88
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) is closely associated with abdominal obesity, dyslipidemia, hypertension, and Type 2 diabetes, which are all features of the metabolic syndrome. The aim of the present study was to elucidate whether NAFLD is associated with carotid atherosclerosis. METHODS: The study population comprised 659 subjects without hepatitis B and C infections and who did not consume alcohol. Fatty infiltrations of liver were detected by abdominal ultrasonography, and intima-media thickness (IMT) and plaque prevalence were estimated by carotid ultrasonography. RESULTS: The mean values of systolic and diastolic pressures, body mass index (BMI), aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, uric acid, total cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, fasting glucose, fasting insulin, homeostasis model of assessment (HOMA) index, hemoglobin A1c, and plasminogen activator inhibitor-1 differed significantly between patients with NAFLD (n=314) and normal controls (n=345). The carotid IMT was 0.817+/-0.212 (mean+/-SD) mm in patients with NAFLD and 0.757+/-0.198 mm in normal controls (p<0.001). The prevalence of carotid plaques was higher in patients with NAFLD (26.4%) than in normal controls (15.9%) (p<0.001). This association persisted significantly after adjusting for age, sex, BMI, HOMA index and individual factors of metabolic syndrome by multiple logistic regression analysis. CONCLUSIONS: Patients with NAFLD are at a high risk of carotid atherosclerosis regardless of metabolic syndrome and classical cardiovascular risk factors. Therefore, the detection of NAFLD should alert to the existence of an increased cardiovascular risk. Moreover, NAFLD might be an independent risk factor for cardiovascular disease.
Aged
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Body Mass Index
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Carotid Arteries/pathology/ultrasonography
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Carotid Artery Diseases/diagnosis/*etiology
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Cholesterol, HDL/blood
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Demography
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Diabetes Mellitus, Type 2/complications/diagnosis
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Diabetic Diet
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Fatty Liver/*complications/diagnosis/ultrasonography
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Female
;
Humans
;
Male
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Metabolic Syndrome X/complications/diagnosis
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Middle Aged
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Obesity/complications/diagnosis
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Regression Analysis
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Risk Factors
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Triglycerides/blood
6.Relationship between Tetrahydrobiopterin and Portal Hypertension in Patients with Chronic Liver Disease.
Won Ki HONG ; Kwang Yong SHIM ; Soon Koo BAIK ; Moon Young KIM ; Mee Yon CHO ; Yoon Ok JANG ; Young Shik PARK ; Jin HAN ; Gaeun KIM ; Youn Zoo CHO ; Hye Won HWANG ; Jin Hyung LEE ; Myeong Hun CHAE ; Sang Ok KWON
Journal of Korean Medical Science 2014;29(3):392-399
Tetrahydrobiopterin (BH4) is an essential cofactor in NO synthesis by endothelial nitric oxide synthase (eNOS) enzymes. It has been previously suggested that reduced intrahepatic BH4 results in a decrease in intrahepatic NO and contributes to increased hepatic vascular resistance and portal pressure in animal models of cirrhosis. The main aim of the present study was to evaluate the relationship between BH4 and portal hypertension (PHT). One hundred ninety-three consecutive patients with chronic liver disease were included in the study. Liver biopsy, measurement of BH4 and hepatic venous pressure gradient (HVPG) were performed. Hepatic fibrosis was classified using the Laennec fibrosis scoring system. BH4 levels were determined in homogenized liver tissues of patients using a high performance liquid chromatography (HPLC) system. Statistical analysis was performed to evaluate the relationship between BH4 and HVPG, grade of hepatic fibrosis, clinical stage of cirrhosis, Child-Pugh class. A positive relationship between HVPG and hepatic fibrosis grade, clinical stage of cirrhosis and Child-Pugh class was observed. However, the BH4 level showed no significant correlation with HVPG or clinical features of cirrhosis. BH4 concentration in liver tissue has little relation to the severity of portal hypertension in patients with chronic liver disease.
Adult
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Aged
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Biopterin/*analogs & derivatives/analysis
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*Chromatography, High Pressure Liquid
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Chronic Disease
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Elasticity Imaging Techniques
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Female
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Hepatic Veins/physiology
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Humans
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Hypertension, Portal/complications/*diagnosis/metabolism
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Liver/pathology
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Liver Cirrhosis/ultrasonography
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Liver Diseases/complications/*diagnosis/metabolism
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Male
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Middle Aged
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Nitric Oxide/metabolism
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Portal Pressure
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Regression Analysis
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Severity of Illness Index
7.Relationship between carotid atherosclerosis and nonalcoholic fatty liver disease.
Chinese Journal of Hepatology 2009;17(11):875-876
Aged
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Body Mass Index
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Carotid Arteries
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diagnostic imaging
;
pathology
;
Carotid Artery Diseases
;
diagnosis
;
epidemiology
;
etiology
;
Cholesterol, HDL
;
blood
;
Fatty Liver
;
complications
;
diagnosis
;
epidemiology
;
Female
;
Humans
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Insulin Resistance
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Intercellular Signaling Peptides and Proteins
;
blood
;
Male
;
Metabolic Syndrome
;
complications
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Middle Aged
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Obesity
;
complications
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Risk Factors
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Triglycerides
;
blood
;
Tunica Intima
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diagnostic imaging
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pathology
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Ultrasonography