2.Clinical significance of histopathologic and ultrastructural pathologic examination in etiological diagnosis of infantile cholestatic diseases.
Rui-qiu ZHAO ; Xiao-qin GUAN ; Zi-guo LUO ; Hong-mei XU
Chinese Journal of Hepatology 2010;18(9):694-698
OBJECTIVETo study the features of histopathologic and ultrastructural pathologic changes of liver biopsy in patients with infantile cholestatic disease, and to investigate its diagnostic significance combining with the clinical data.
METHODSThirty-six children diagnosed as infantile cholestatic disease and received liver biopsy in Chongqing Medical University Children's Hospital from Jun 2007 to Oct 2008 were enrolled and the pathologic and ultrastructural pathologic changes of liver were analyzed.
RESULTSMorphologic changes under light microscope in liver tissues included hepatocyte swelling, hepatocyte denaturation, hepatocyte necrosis, multinucleated giant cell formation, bile duct proliferation, fiber tissues proliferation and inflammatory cells infiltration in liver lobules and portal regions. The characteristics of cholestasis including intralobular cholestasis, acinus formation, feather-like cytoplasmic filaments and bile stasis in bile canaliculi were observed. The morphologic changes of biliary atresia were observed in 7 cases whose image investigations showed no obstruction of biliary tract. Nuclear changes, resolution of cytoplasm, inflammatory cell infiltration, collagen fiber proliferation and increased number of lysosomes were observed under electromicroscope. Two cases of glycogen storage disease, 1 case of Niemann-Pick disease and 1 case of lipid storage disease with unknown cause were confirmed by the combination of histological changes and clinical manifestations.
CONCLUSIONCommon pathologic changes of liver tissues existed under light microscope or electroscope. The diagnosis of hereditary metabolic disorders could be made increasingly by application of these two technologies in clinical practice. It is difficult to diagnose biliary atresia in early childhood by image investigations and the pathological changes of liver tissues are helpful.
Cholestasis ; diagnosis ; etiology ; pathology ; Female ; Humans ; Infant ; Liver ; pathology ; Liver Diseases ; diagnosis ; etiology ; pathology ; Male
3.Development of prognostic models of liver diseases.
Jun-yong ZHANG ; Fu-kui ZHANG ; Ji-dong JIA ; Bao-en WANG
Chinese Journal of Hepatology 2005;13(11):876-877
5.Q fever endocarditis with multi-organ complication: a case report.
Li-juan ZHANG ; Xiu-ping FU ; Jing-shan ZHANG
Chinese Medical Journal 2006;119(18):1580-1582
Aged
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Cysts
;
etiology
;
Diagnosis, Differential
;
Endocarditis, Bacterial
;
complications
;
diagnosis
;
Humans
;
Liver Diseases
;
etiology
;
Lung Diseases
;
etiology
;
Male
;
Q Fever
;
complications
;
diagnosis
6.Current status of liver diseases in Korea: Toxic and alcoholic liver diseases.
The Korean Journal of Hepatology 2009;15(Suppl 6):S29-S33
The study of the epidemiology of toxic liver injury has been limited in Korea. The number of hospitalizations for toxic liver injury has been estimated to be 2,400 persons per year. About 30~40% of fulminant hepatitis was attributed to toxic hepatitis. The frequent causative agents of toxic hepatitis in Korea are herbal medicines (34~40%), folk remedies (23~34%), and prescribed medicines (24~55%). However, the most common agents causing severe liver injury including fulminant hepatitis are herbal medicine and folk remedies. Antituberculosis drugs and acetaminophen are two common causes of fulminant hepatitis among prescribed drugs. Alcohol is one of the leading causes of chronic liver disease in Korea. No nationwide study on the epidemiology of alcoholic liver disease (ALD) has been carried out, but 7~31% of cirrhosis has been reported to be alcoholic in a few single-center studies. Alcohol could be a risk factor for the development of hepatocellular carcinoma (HCC) in chronic viral hepatitis. Several studies have shown that alcohol increased the risk of HCC in liver cirrhosis with HBsAg or anti-HCV. Furthermore, alcoholic cirrhosis with occult hepatitis B virus infection increased the risk of HCC.
Drug-Induced Liver Injury/diagnosis/*epidemiology/etiology
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Humans
;
Korea/epidemiology
;
Liver Cirrhosis, Alcoholic/complications/epidemiology
;
Liver Diseases, Alcoholic/complications/*epidemiology
;
Liver Neoplasms/etiology
;
Risk Factors
7.Clinical and pathological analysis of mesenchymal hamartoma of liver.
Dan LI ; Xiang-Hong YANG ; Xiao-Yin CHANG
Chinese Journal of Contemporary Pediatrics 2011;13(8):684-685
Child
;
Child, Preschool
;
Female
;
Hamartoma
;
diagnosis
;
etiology
;
pathology
;
Humans
;
Immunohistochemistry
;
Infant
;
Liver Diseases
;
diagnosis
;
etiology
;
pathology
;
Male
8.Invasive Aspergillosis Arising from Ureteral Aspergilloma.
Hoon CHOI ; Il Sang KANG ; Hun Soo KIM ; Young Hwan LEE ; Ill Young SEO
Yonsei Medical Journal 2011;52(5):866-868
Ureteral obstruction may develop in immunocompromised patients with an Aspergillus fungal infection. Infections can progress to invasive aspergillosis, which is highly lethal. We report a case of a 56-year-old man with alcoholic cirrhosis of the liver and diabetes. He had ureteral aspergilloma, discovered as a saprophytic whitish mass. It was treated by ureteroscopic removal, however, he refused antifungal treatment. His condition progressed to invasive aspergillosis, and died from sepsis and hepatorenal syndrome.
Aspergillosis/diagnosis/*etiology
;
Diabetes Complications
;
Fatal Outcome
;
Humans
;
Immunocompromised Host
;
Liver Cirrhosis, Alcoholic/complications
;
Male
;
Middle Aged
;
Ureteral Diseases/diagnosis/*etiology
;
Ureteral Obstruction/diagnosis/etiology
10.The progress of study on hepatogenic diabetes.
Chinese Journal of Hepatology 2002;10(6):476-478
Diabetes Mellitus
;
diagnosis
;
etiology
;
therapy
;
Humans
;
Liver Diseases
;
complications
;
Research
;
trends
;
Research Design