7.A diagnostic model for alcoholic liver disease based on a generalized regression neural network.
Chinese Journal of Hepatology 2013;21(4):304-307
OBJECTIVETo study the feasibility and rationale of using a generalized regression neural network model integrated with multiple disease indicators for diagnosing alcoholic liver disease (ALD).
METHODSALD indicators were identified by reviewing the clinical testing results of 40 ALD patients from the literature and 135 patients from the Second Xiangya Hospital of Central South University, who were also classified by physician experts upon clinical consultation. Seven indicators were selected as diagnosis indexes and applied to a general regression neural network diagnostic model. Thirty-four of the reported patients and 120 of the clinical patients were selected for use as training samples to establish the indicator recognition pattern for the model, and the remaining six and 15 patients from the two respective groups were selected for use as testing samples to determine the model's diagnostic ability.
RESULTSThe model provided a correct diagnosis of ALD sub-classification for 94.1% (32/34) of the reported patients and 100% (120/120) of the clinical patients in the training set. The correct diagnosis rates achieved with the training sets were 100% for both the reported patient group (6/6) and the clinical patient group (15/15), indicating that the results of the diagnostic model were in good agreement with the ALD classifications generated by the clinical expert consultations.
CONCLUSIONThe general regression neural network model based on multiple indicators of ALD is capable of providing accurate and comprehensive diagnosis of ALD and may be feasible for clinical applications.
Humans ; Liver Diseases, Alcoholic ; diagnosis ; Neural Networks (Computer)
8.Current status of liver diseases in Korea: Toxic and alcoholic liver diseases.
The Korean Journal of Hepatology 2009;15(Suppl 6):S29-S33
The study of the epidemiology of toxic liver injury has been limited in Korea. The number of hospitalizations for toxic liver injury has been estimated to be 2,400 persons per year. About 30~40% of fulminant hepatitis was attributed to toxic hepatitis. The frequent causative agents of toxic hepatitis in Korea are herbal medicines (34~40%), folk remedies (23~34%), and prescribed medicines (24~55%). However, the most common agents causing severe liver injury including fulminant hepatitis are herbal medicine and folk remedies. Antituberculosis drugs and acetaminophen are two common causes of fulminant hepatitis among prescribed drugs. Alcohol is one of the leading causes of chronic liver disease in Korea. No nationwide study on the epidemiology of alcoholic liver disease (ALD) has been carried out, but 7~31% of cirrhosis has been reported to be alcoholic in a few single-center studies. Alcohol could be a risk factor for the development of hepatocellular carcinoma (HCC) in chronic viral hepatitis. Several studies have shown that alcohol increased the risk of HCC in liver cirrhosis with HBsAg or anti-HCV. Furthermore, alcoholic cirrhosis with occult hepatitis B virus infection increased the risk of HCC.
Drug-Induced Liver Injury/diagnosis/*epidemiology/etiology
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Humans
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Korea/epidemiology
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Liver Cirrhosis, Alcoholic/complications/epidemiology
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Liver Diseases, Alcoholic/complications/*epidemiology
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Liver Neoplasms/etiology
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Risk Factors
10.Nonalcoholic fatty liver disease in the elderly.
Chinese Journal of Hepatology 2016;24(2):92-95
Along with the aging process, the spectrum of liver disease changes greatly. Nonalcoholic fatty liver disease (NAFLD) in elderly people lead to low liver function and is also the major cause of extrahepatic diseases, such as cardiovascular disease and malignant tumor. This review provides an overview of the morphological structure and function of the liver in aged people, and discusses the characteristics of weakness, malnutrition and limited movement in the elderly, as well as the current status of multiple diseases and multiple drug use. Finally, this article puts forward some appropriate regimens for the diagnosis and treatment of NAFLD in elderly people to provide a reference for clinical practice.
Aged
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Cardiovascular Diseases
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Humans
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Liver
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pathology
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Malnutrition
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Neoplasms
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Non-alcoholic Fatty Liver Disease
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diagnosis
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pathology
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therapy
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Risk Factors
Result Analysis
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