3.Cirrhotic Cardiomyopathy.
Moon Young KIM ; Soon Koo BAIK
The Korean Journal of Hepatology 2007;13(1):20-26
Most patients with liver cirrhosis have hyperdynamic circulatory alterations with increased cardiac output, and decreased systemic vascular resistance and arterial pressure. But, in spite of the increased resting cardiac output, ventricular contractile response to stressful stimuli is attenuated in cirrhotic patients which is termed as cirrhotic cardiomyopathy. The prevalence of cirrhotic cardiomyopathy remains unknown at present. Clinical features include structural, histological, electrophysiological, systolic and diastolic dysfunction. Multiple factors are considered as responsible, including impaired beta-adrenergic receptor signal transduction, abnormal membrane biophysical characteristics, and increased activity of cardiodepressant systems mediated by cGMP. Generally, cirrhotic cardiomyopathy with overt severe heart failure is rare. However, major stresses on the cardiovascular system such as liver transplantation, infections and insertion of transjugular intrahepatic portosystemic shunts (TIPS) can unmask the presence of cirrhotic cardiomyopathy and thereby convert latent to overt heart failure. Cirrhotic cardiomyopathy may also contribute to the pathogenesis of hepatorenal syndrome and circulatory failure in liver cirrhosis. Because of the marked paucity of treatment studies, current recommendations for management are empirical, nonspecific measures. Further studies for pathogenesis and new therapeutic strategies in this area are required.
Cardiomyopathies/*diagnosis/*etiology/therapy
;
Humans
;
Liver Cirrhosis/*complications
;
Prognosis
4.Progress in the diagnosis and treatment of ascites in cirrhosis: introduction of EASL clinical practice guidelines on management of ascites in cirrhosis.
Chinese Journal of Hepatology 2010;18(12):951-954
Ascites
;
diagnosis
;
etiology
;
therapy
;
Europe
;
Humans
;
Liver Cirrhosis
;
complications
;
diagnosis
;
therapy
;
Practice Guidelines as Topic
5.Nutmeg liver cardiac cirrhosis caused by constrictive pericarditis.
Kyoung Hwang SHIN ; Hyun Don JOO ; Il Han SONG
The Korean Journal of Internal Medicine 2015;30(6):938-939
No abstract available.
Aged
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Biopsy
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Humans
;
Liver Cirrhosis/diagnosis/*etiology/therapy
;
Male
;
Pericarditis, Constrictive/*complications/diagnosis/therapy
;
Tomography, X-Ray Computed
6.Update hepatology in 2008.
Chinese Journal of Hepatology 2009;17(1):1-4
Carcinoma, Hepatocellular
;
diagnosis
;
therapy
;
Gastroenterology
;
trends
;
Hepatitis, Viral, Human
;
diagnosis
;
therapy
;
Humans
;
Liver Cirrhosis
;
diagnosis
;
therapy
;
Liver Diseases
;
diagnosis
;
therapy
;
Liver Failure, Acute
;
etiology
;
therapy
;
Liver Neoplasms
;
diagnosis
;
therapy
;
Retrospective Studies
7.Liver transplantation for acute-on-chronic liver failure from erythropoietic protoporphyria.
Pyoung Jae PARK ; Shin HWANG ; Young Il CHOI ; Young Dong YU ; Gil Chun PARK ; Sung Won JUNG ; Sam Youl YOON ; Gi Won SONG ; Tae Yong HA ; Sung Gyu LEE
Clinical and Molecular Hepatology 2012;18(4):411-415
Erythropoietic protoporphyria (EPP) is an inherited disorder of the heme metabolic pathway that is characterized by accumulation of protoporphyrin in the blood, erythrocytes, and tissues, and cutaneous manifestations of photosensitivity, all resulting from abnormalities in ferrochelatase (FECH) activity due to mutations in the FECH gene. Protoporphyrin is excreted by the liver, and excess protoporphyrin leads to cholelithiasis with obstructive episodes and chronic liver disease, finally progressing to liver cirrhosis. Patients with end-stage EPP-associated liver disease require liver transplantation. We describe here a 31-year-old male patient with EPP who experienced acute-on-chronic liver failure and underwent deceased-donor liver transplantation. Surgical and postoperative care included specific shielding from exposure to ultraviolet radiation to prevent photosensitivity-associated adverse effects. The patient recovered uneventfully and was doing well 24 months after transplantation. Future prevention and treatment of liver disease are discussed in detail.
Acute Disease
;
Adult
;
End Stage Liver Disease/etiology/pathology/*therapy
;
Ferrochelatase/genetics/metabolism
;
Humans
;
Liver Cirrhosis/diagnosis
;
*Liver Transplantation
;
Male
;
Mutation
;
Protoporphyria, Erythropoietic/complications/*diagnosis/pathology
8.Progress in the diagnosis and treatment of hepatic hydrothorax.
Hong-cui LI ; Xiao LI ; Cheng-wei TANG
Chinese Journal of Hepatology 2009;17(12):958-960
Ascites
;
diagnosis
;
etiology
;
therapy
;
Diagnostic Imaging
;
methods
;
Humans
;
Hydrothorax
;
diagnosis
;
etiology
;
therapy
;
Hypertension, Portal
;
complications
;
Liver Cirrhosis
;
complications
;
Liver Transplantation
;
Pleural Effusion
;
diagnosis
;
etiology
;
therapy
;
Portasystemic Shunt, Transjugular Intrahepatic
9.Thoracoscopy for diagnosis and management of refractory hepatic hydrothorax.
Dian-jie LIN ; Min ZHANG ; Gui-xin GAO ; Bin LI ; Mao-fen WANG ; Ling ZHU ; Li-fu XUE
Chinese Medical Journal 2006;119(5):430-434
Adult
;
Female
;
Humans
;
Hydrothorax
;
diagnosis
;
etiology
;
therapy
;
Liver Cirrhosis
;
complications
;
Male
;
Middle Aged
;
Talc
;
therapeutic use
;
Thoracoscopy
;
methods
10.Four patients with hepatitis A presenting with fulminant hepatitis and acute renal failure and who underwent liver transplantation.
Se Hoon OH ; Joon Hyoek LEE ; Ji Won HWANG ; Hye Young KIM ; Chang Hoon LEE ; Geum Youn GWAK ; Moon Seok CHOI ; Kwang Chul KOH ; Seung Woon PAIK ; Byung Chul YOO
The Korean Journal of Hepatology 2009;15(3):362-369
Hepatitis A is generally known as a mild, self-limiting disease of the liver, but in rare instances it can progress to fulminant hepatitis, which may require liver transplantation for recovery. Such cases are known to be related to old age and underlying liver disease. We report four cases of hepatitis A in which patients presented with fulminant hepatitis and acute renal failure and underwent liver transplantation. The following common features were observed in our cases: (1) occurrence in relatively old age (> or =39 years old), (2) association with acute renal failure, (3) presence of hepatomegaly, and (4) microscopic features of submassive hepatic necrosis.
Adult
;
Age Factors
;
Female
;
Hepatitis/complications/*diagnosis/therapy
;
Hepatitis A/complications/*diagnosis
;
Hepatomegaly/diagnosis/etiology
;
Humans
;
Kidney Failure, Acute/complications/*diagnosis
;
Liver/pathology
;
Liver Cirrhosis/diagnosis/etiology
;
*Liver Transplantation
;
Male
;
Tomography, X-Ray Computed