1.Research progress on cirrhosis reversal and recompensation.
Jing Hang XU ; Yan Yan YU ; Xiao Yuan XU
Chinese Journal of Hepatology 2023;31(7):673-676
Previously, liver lesions in cirrhosis were considered irreversible, especially because the condition aggravated gradually after entering the decompensated phase, thus making it difficult to return to the compensated phase. At present, more and more evidence shows that some patients with decompensated liver cirrhosis can be recompensated after the cause is controlled and complications are managed. This article explores the research progress related to LC reversal and recompensation from three aspects: liver histopathology, liver function, and clinical complications.
Humans
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Liver Cirrhosis/complications*
2.Cirrhosis recompensation: clinical complications.
Chinese Journal of Hepatology 2023;31(7):684-687
Cirrhosis recompensation is a new concept proposed in recent years to describe the clinical stage of the overall reversal of patients with decompensated cirrhosis. The recompensation of cirrhosis is discussed here from the perspective of clinical complications.
Humans
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Liver Cirrhosis/complications*
4.Focusing on timing selection and whole-course management of liver transplantation treatment for patients with acute-on-chronic liver failure.
Chinese Journal of Hepatology 2023;31(6):561-563
Acute-on-chronic liver failure (ACLF) is a clinical syndrome of acute decompensation accompanied by organ failure that occurs on the basis of chronic liver disease and has a high short-term mortality rate. Currently, there are still differences in relation to the definition of ACLF; thus, baseline characteristics and dynamic changes are important bases for clinical decision-making in patients with liver transplantation and others. The basic strategies for treating ACLF currently include internal medicine treatment, artificial liver support systems, and liver transplantation. Multidisciplinary active collaborative management throughout the whole course is of great significance for further improving the survival rate in patients with ACLF.
Humans
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Liver Transplantation
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Acute-On-Chronic Liver Failure/complications*
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Survival Rate
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Liver Cirrhosis/complications*
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Prognosis
5.Hepatic sarcoidosis with severe jaundice leading to cirrhosis: a case report.
Hong-yun DONG ; Yu-qiang MI ; Fei LI
Chinese Journal of Hepatology 2007;15(8):629-629
Aged
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Female
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Humans
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Jaundice
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complications
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Liver Cirrhosis
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etiology
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Liver Diseases
;
complications
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Sarcoidosis
;
complications
6.The Correlation of Child-Pugh Score, PGA Index and MELD Score in the Patient with Liver Cirrhosis and Hepatocellular Carcinoma According to the Cause of Alcohol and Hepatitis B Virus.
Byoung Sik MUN ; Heok Soo AHN ; Deuk Soo AHN ; Seung Ok LEE
The Korean Journal of Hepatology 2003;9(2):107-115
BACKGROUND/AIMS: To determine the treatment modalities and the prognosis of a patient with liver cirrhosis, quantitative estimation of liver function is important. We assessed the Child-Pugh score (CPS), the common method as a severity index for the cirrhosis, the Promthombin, gamma GT, and Apolipoprotein A1 (PGA) index and model for end-stage liver disease (MELD) score. The purpose of this study was to evaluate the correlation between these indices in the patients with cirrhosis only and hepatocellular carcinoma (PHC), according to underlying causes (HBV and alcohol). METHODS: We reviewed medical records of 339 cirrhotic patients with/without hepatocellular carcinoma and divided patient groups by disease and underlying cause: cirrhosis caused by alcohol; LC-Al, cirrhosis caused by HBV; LC-B, hepatocellular carcinoma with cirrhosis caused by alcohol; HCC-Al, hepatocellular carcinoma with cirrhosis caused by HBV; HCC-B. We assessed the CPS, PGA index and MELD score and calculated the correlation coefficient between these scores. RESULTS: Among the total of 339 patients, 201 patients were diagnosed on the liver cirrhosis only, and 138 patients on the hepatocellular carcinoma with cirrhosis. In each groups, mean score values were not significantly different in CPS, PGA index and MELD score. The correlation of CPS, PGA index and MELD score in all groups, except for the correlation of PGA index and MELD score in HCC-Al group, was significantly positive (p<0.05). Compared to correlation coefficients between three indices, the patients with cirrhosis only had higher tendencies than the patients with hepatocellular carcinoma. The patients by HBV had higher tendencies than by alcohol. CONCLUSIONS: The correlations between CPS, PGA index and MELD score showed significantly positive correlations in the patients with liver cirrhosis only and hepatocellular carcinoma with cirrhosis (except in HCC-Al group). The patients with cirrhosis only had higher correlation coefficients than the patients with PHC and the patients by HBV had higher than by alcohol.
Adult
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Aged
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Carcinoma, Hepatocellular/*complications
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Female
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Hepatitis B/*complications
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Humans
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Liver Cirrhosis/*complications
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Liver Cirrhosis, Alcoholic/complications
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Liver Neoplasms/*complications
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Male
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Middle Aged
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Prognosis
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*Severity of Illness Index
7.Can We Accurately Assess Liver Fibrosis with Fibroscan(R) Using Fewer Valid Measurements?.
Omid POURNIK ; Seyed Moayed ALAVIAN ; Saeid ESLAMI
Yonsei Medical Journal 2013;54(2):541-542
No abstract available.
Female
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Hepatitis B, Chronic/*complications
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Humans
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Liver Cirrhosis/*diagnosis
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Male
8.Cirrhotic Cardiomyopathy.
Moon Young KIM ; Soon Koo BAIK
The Korean Journal of Hepatology 2007;13(1):20-26
Most patients with liver cirrhosis have hyperdynamic circulatory alterations with increased cardiac output, and decreased systemic vascular resistance and arterial pressure. But, in spite of the increased resting cardiac output, ventricular contractile response to stressful stimuli is attenuated in cirrhotic patients which is termed as cirrhotic cardiomyopathy. The prevalence of cirrhotic cardiomyopathy remains unknown at present. Clinical features include structural, histological, electrophysiological, systolic and diastolic dysfunction. Multiple factors are considered as responsible, including impaired beta-adrenergic receptor signal transduction, abnormal membrane biophysical characteristics, and increased activity of cardiodepressant systems mediated by cGMP. Generally, cirrhotic cardiomyopathy with overt severe heart failure is rare. However, major stresses on the cardiovascular system such as liver transplantation, infections and insertion of transjugular intrahepatic portosystemic shunts (TIPS) can unmask the presence of cirrhotic cardiomyopathy and thereby convert latent to overt heart failure. Cirrhotic cardiomyopathy may also contribute to the pathogenesis of hepatorenal syndrome and circulatory failure in liver cirrhosis. Because of the marked paucity of treatment studies, current recommendations for management are empirical, nonspecific measures. Further studies for pathogenesis and new therapeutic strategies in this area are required.
Cardiomyopathies/*diagnosis/*etiology/therapy
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Humans
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Liver Cirrhosis/*complications
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Prognosis
9.Cardiogenic liver cirrhosis with a large amount of ascitic fluid: a case report.
Tao YAN ; Hui-fen WANG ; Wei JI ; Hong ZHAO ; Hong-ling LIU ; Guang-de ZHOU
Chinese Journal of Hepatology 2007;15(7):549-550
Adult
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Ascites
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etiology
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Ascitic Fluid
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Female
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Humans
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Liver Cirrhosis
;
complications
10.Analysis on similarity between traditional Chinese medicine syndromes and information on disease in patients with post-hepatitis cirrhosis.
Chinese Journal of Integrated Traditional and Western Medicine 2009;29(5):398-402
OBJECTIVETo explore the similarity between traditional Chinese medicine (TCM) syndromes and clinical symptoms and biological parameters in patients with post-hepatitis cirrhosis (PHC).
METHODSAfter the variants had been normalized, 4 methods for similarity analysis, i.e. method of cosine distance, correlation coefficient, D and spectral similarity, were used to analyze the similarity of clinical characteristic information (symptoms), biological parameters and TCM syndromes obtained from 279 patients with PHC.
RESULTSThe corresponding similarity matrixes were used to reflect the similarity between TCM syndromes and symptoms and biological parameters respectively, results obtained by the 4 methods were basically identical. As compared with the traditional correlation coefficient analysis, the other three methods showed a higher level of matching, sensitivity, rationality in quantitative accepting-rejecting and reliability, and were more accordant with clinical practice.
CONCLUSIONThe resemblance between TCM syndromes and clinical information on disease obtained from similarity analysis is basically in accordance with the clinical practice, so, the technique could be taken as a method for finding the characteristics of TCM syndrome with simplified clinical parameters.
Hepatitis ; complications ; Humans ; Liver Cirrhosis ; diagnosis ; etiology ; Medicine, Chinese Traditional