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7.The value of antimitochondrial antibody and its subtypes in the diagnosis of primary biliary cirrhosis.

Ding-Kang YAO ; Wei-Fen XIE ; Wei-Zhong CHEN ; Hai-Ying LIU ; Xiao-Qing TU ; Li-Ying FAN

Chinese Journal of Hepatology 2005;13(1):9-11

OBJECTIVEA study on the value of antimitochondrial antibody (AMA) and its subtypes anti-M2, anti-M4, and anti-M9 in diagnosing primary biliary cirrhosis (PBC).

METHODSAntimitochondrial antibody was detected by indirect immunofluorescence and anti-M2, anti-M4 and anti-M9 by Western blotting. AMA and anti-M2 of 78 PBC patients, of 35 non-PBC hepato-biliary disease patients and 20 healthy controls were studied and anti-M2, anti-M4 and anti-M9 were studied in 30 of the 78 PBC patients.

RESULTS96.2% (75/78) of PBC patients were AMA positive and 94.9% (74/78) of PBC patients were anti-M2 positive. Only three among the 35 non-PBC patients were positive for AMA (one with very low titre). None of the 35 non-PBC patients was anti-M2 positive. AMA and anti-M2 were negative in all the healthy controls. Among the 30 anti-M2 positive patients, 16 patients were anti-M4 positive (16/30, 53.3%) and 4 patients were anti-M9 positive (4/30, 13.3%).

CONCLUSIONAMA and its subtypes (special anti-M2) are important sero-immunological markers for the diagnosis of PBC.

Autoantibodies ; blood ; classification ; Female ; Humans ; Liver Cirrhosis, Biliary ; diagnosis ; immunology ; Male ; Mitochondria, Liver ; immunology

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3.Research in diagnosing hepatic fibrosis with serological parameters.

4.Non-invasive diagnosis of hepatic fibrosis.

5.Serological markers of and a diagnostic profile model for liver fibrosis.

6.Overlap syndrome in autoimmune liver diseases.

7.The value of antimitochondrial antibody and its subtypes in the diagnosis of primary biliary cirrhosis.

8.Progress in non-invasive diagnostic model of hepatic fibrosis.

9.Plasma proteomic pattern predicts the stages of rat liver fibrosis.

10.Laboratory diagnosis of liver fibrosis and its future.

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