No abstract available.
Liver* ; Radioactivity* ; Radionuclide Imaging*

No abstract available.
Humans ; Liver Cirrhosis* ; Liver* ; Radionuclide Imaging*

No abstract available.
Humans ; Liver Cirrhosis* ; Liver* ; Radionuclide Imaging*

Authors recommend ultrasound be used as a screening test in evaluation of suspected liver masses. Besides its speedness, wide availability, easy scheduling and lack of radiation hazard, ultrasound is higher in sensitivity,better in characterization of a lesion, and better in staging of a cancer than radionuclide scanning Ultrasoundcould be used to delineated pedunculated hepatoma and anatomic variations, to differentiate intahepatic from extrahepatic lesions, and to evaluate multiple organs simultaneously, while radionuclide scanning can not afford any benefit in these aspects. In addition, ultrasound could be used as a guide for diagnostic or therapeurtic aspiration.
Carcinoma, Hepatocellular ; Liver ; Mass Screening ; Radionuclide Imaging ; Ultrasonography

No abstract available.
Adult ; Carcinoma, Hepatocellular/radiography/radionuclide imaging/ultrasonography ; Granuloma, Plasma Cell/pathology/*radiography/radionuclide imaging ; Humans ; Liver Diseases/pathology/*radiography/radionuclide imaging ; Liver Neoplasms/radiography/radionuclide imaging/ultrasonography ; Magnetic Resonance Imaging ; Male ; Tomography, X-Ray Computed

No abstract availble.
Aged ; Humans ; Liver Neoplasms/radiography/*radionuclide imaging/*secondary ; Male ; Neoplasm Recurrence, Local/*radionuclide imaging ; *Positron-Emission Tomography ; Rectal Neoplasms/pathology/*radionuclide imaging ; Sigmoidoscopes

The purpose of this volunteer study was to investigate whether pretreatment with UDCA before the administration of 99mTc DISIDA affects the biliary excretion of the DISIDA, and whether it can shorten the total imaging time. Ten young, healthy volunteers (eight males, two females, mean age: 26.3 +/- 2.1 years) participated in the study. Hepatobiliary scintigraphies were performed twice per volunteer within three days, for the control and the UDCA-pretreated studies. In the control study, the gallbladder (GB) was observed first in four cases and the intestine was observed first in another four cases; in contrast, in the UDCA challenge study, the GB was observed first in eight cases. The quantitative results for the factors related to the GB differed significantly between the control and challenge studies. When the subjects were pretreated with UDCA, the time duration until visualization of the GB was shortened, and the maximum activity of the GB became more intense. In conclusion, UDCA pretreatment before hepatobiliary scintigraphy can shorten the total imaging time for evaluating functional obstructions of the cystic duct and increase the specificity of the process.
Adult ; Biliary Tract/*radionuclide imaging ; Female ; Humans ; Liver/*radionuclide imaging ; Male ; Radionuclide Imaging/*methods ; Radiopharmaceuticals/*pharmacokinetics ; Technetium Tc 99m Disofenin/*pharmacokinetics ; Ursodeoxycholic Acid/*pharmacology

BACKGROUND/AIMS: Changes in gastric motility in patients with liver cirrhosis is not yet established in South Korea. In this study changes in gastric emptying time with attention to factors that effect this change in patients with liver cirrhosis were investigated. METHODS: Fifteen patients with liver cirrhosis (11 males and 4 females) and 15 healthy controls (11 males and 4 females) were enrolled in this study. Gastric emptying time was measured by gastric scintigraphy using a dual-head gamma camera after ingestion of the mixture of 99mTc-labeled egg and fried rice (754Kcal). Data acquisition was performed for 120 minutes with 15 minutes interval and geometric mean and decay correction were calculated for gastric emptying time. RESULTS: There were no differences in age and sex between the two groups. The half time of soild gastric emptying was 78.0+/-87.0 minutes and 70.2+/-2.8 minutes for liver cirrhosis and healthy control group, respectively (p>0.05). The level of serum cholesterol was statistically correlated with gastric emptying time (B=-0.165, p<0.01). CONCLUSIONS: There was no significant difference in gastric emptying time between liver cirrhosis and healthy control group.
Cholesterol ; Eating ; Gamma Cameras ; Gastric Emptying* ; Humans ; Korea ; Liver Cirrhosis* ; Liver* ; Male ; Ovum ; Radionuclide Imaging

The reduction in the amount of asialoglycoprotein (ASGP) receptor, which resides exclusively on the plasma membrane of functioning mammalian hepatocytes, as a consequence of hepato-cellular damage has been demonstrated in various pathologic conditions of the liver. Galac tosylated human serum albumin (GSA) is a newly developed receptor-binding agent, specific for the ASGP receptor. Tc-99m GSA binds quantitatively to liver ASGP receptors and the rate of accumulation in the liver is dependent on hepatic function represented as the amount of receptor, as well as the amount of ligand injected, its affinity to the receptor and the hepatic blood flow. The findings of Tc-99m GSA scintigraphy were reported to reflect the hepatic function of the patients with large hepatic tumors, obstructive jauniice, acute and chronic liver disease. Tc-99m GSA scintigraphy is an easy and reliable test and has the clinical potentials to evaluate the liver function in the patients with hepatic disorders.
Asialoglycoprotein Receptor ; Cell Membrane ; Evaluation Studies as Topic* ; Hepatocytes ; Humans ; Liver Diseases ; Liver* ; Radionuclide Imaging* ; Serum Albumin*

99mTc-galactosyl human serum albumin (Tc-GSA) is a radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically present in the hepatocyte membrane. Because these receptors are decreased in hepatic parenchymal damage, the degree of Tc-GSA accumulation in the liver correlates with findings of liver function test. Hepatic images were performed with Tc-GSA in patients with acute hepatic dysfunction by Amantia Subjunquillea poisoning, and compared with these of liver ultrasonography (USG). Tc-GSA (185 MBq, 3 mg of GSA) was injected intravenously, and dynamic images were recorded for 30 minutes. Time-activity curves for the heart and liver were generated from regions of interest for the whole liver and precordium. Degree of hepatic uptake and clearance rate of Tc-GSA were generated by visual interpretation and semiquantitative analysis parameters (receptor index: LHL15 and index of blood clearance: HH15). Visual assessment of GSA scintigraphy revealed mildly decreased liver uptake in all of subjects. The mean LHL15 and HH15 were 0.886 and 0.621, graded as mild dysfunction in 2, and mild to moderate dysfunction in 1 subject. In contrast, liver USG showed no remarkable changes of hepatic parenchyme. Tc-GSA scintigraphy was considered as a useful imaging modality in the assessment of the hepatic dysfunction.
Asialoglycoprotein Receptor ; Heart ; Hepatocytes ; Humans* ; Liver Function Tests ; Liver* ; Membranes ; Poisoning* ; Radionuclide Imaging* ; Serum Albumin* ; Ultrasonography*