2.Nonalcoholic fatty liver disease and immune disturbance.
Lan WANG ; You-ming LI ; Fu-chu HE ; Ying JIANG
Chinese Journal of Hepatology 2008;16(11):870-871
3.The immunological mechanisms of liver fibrosis.
Chinese Journal of Hepatology 2010;18(8):566-568
4.Update on hepatic fibrosis research.
Chinese Journal of Hepatology 2010;18(8):563-565
6.The role of hepatic sinusoids in local control of the immune response.
Chinese Journal of Hepatology 2002;10(3):229-230
Animals
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Endothelium
;
immunology
;
Humans
;
Immunity
;
Kupffer Cells
;
immunology
;
Liver
;
immunology
7.Progress in immune mechanism for process of liver failure.
Chinese Journal of Hepatology 2012;20(10):733-736
8.γδ T cells in liver diseases.
Frontiers of Medicine 2018;12(3):262-268
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.
Animals
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Cytokines
;
immunology
;
Humans
;
Liver Diseases
;
immunology
;
Liver Regeneration
;
immunology
;
Mice
;
T-Lymphocytes, Regulatory
;
immunology
9.NKT cells in liver diseases.
Shasha ZHU ; Huimin ZHANG ; Li BAI
Frontiers of Medicine 2018;12(3):249-261
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma. Controversial results from previous studies are discussed, and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver diseases, which might be caused by changes in natural killer T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CD1d-expressing cells or bystander cells.
Animals
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Autoimmune Diseases
;
immunology
;
Humans
;
Liver
;
pathology
;
Liver Diseases
;
immunology
;
Natural Killer T-Cells
;
immunology
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