Objective To explore the application of standard interaction theory in the nursing care of multidrug resistance patients .Methods 113 cases of multidrug resistance inpatients were randomly divided into the observation group (58 cases) and the control group (55 cases).The observation group was give the nursing care based on the standard interaction theory , while the control group used the conventional nursing method .The psychological condition , medication adherence , treatment effect and satisfaction were compared between the two groups.Results After the intervention, the average score of anxiety in the observation group decreased from (18.51 ±3.71) to (8.20 ±2.82); the average score of depression in the observation group decreased from (57.06 ±8.29) to (35.74 ±10.80).The average score of anxiety in the control group decreased from (18.14 ±3.36) to (13.30 ±4.90); the average score of depression in the control group decreased from (56.94 ±7.24) to (54.74 ±7.25).The differences between groups were significant (t=-6.924,-11.100, respectively;P<0.05).The percentage of medication adherence was 96.5% in the observation group, which was significantly higher than 60.0% in the control group.The treatment effect of the observation group (52 cases) was better than (15 cases) in the control group.The satisfaction was (89.53 ±8.187) in the observation group than (79.53 ±10.563) in the control group.The difference between groups was significant (Z=-7.018,-6.646, respectively;t=5.480;P<0.05).Conclusions The standard interaction theory had remarkable effect in the application of nursing care of multidrug resistance patients .It can improve patients ’ psychological condition and medication adherence and satisfaction , thus it is worthy of promoting .

Inflammatory diseases are common medical conditions seen in disorders of human immune system. There is a great demand for anti-inflammatory drugs. There are major inflammatory mediators in arachidonic acid metabolic network. Several enzymes in this network have been used as key targets for the development of anti-inflammatory drugs. However, specific single-target inhibitors can not sufficiently control the network balance and may cause side effects at the same time. Most inflammation induced diseases come from the complicated coupling of inflammatory cascades involving multiple targets. In order to treat these complicated diseases, drugs that can intervene multi-targets at the same time attracted much attention. The goal of this review is mainly focused on the key enzymes in arachidonic acid metabolic network, such as phospholipase A2, cyclooxygenase, 5-lipoxygenase and eukotriene A4 hydrolase. Advance in single target and multi-targe inhibitors is summarized.
Animals ; Anti-Inflammatory Agents ; therapeutic use ; Arachidonate 5-Lipoxygenase ; metabolism ; therapeutic use ; Arachidonic Acid ; metabolism ; Cyclooxygenase Inhibitors ; therapeutic use ; Drug Delivery Systems ; methods ; Epoxide Hydrolases ; antagonists & inhibitors ; metabolism ; therapeutic use ; Humans ; Inflammation ; drug therapy ; Lipoxygenase Inhibitors ; Metabolic Networks and Pathways ; drug effects ; Phospholipase A2 Inhibitors ; Phospholipases A2 ; metabolism ; therapeutic use ; Prostaglandin-Endoperoxide Synthases ; metabolism