Objective To study the seizure of uremic encephalopathy and investigate the treatment of this disease. Methods Review analyse clinical data of 13 eases uremic eneephalopathy. Results 8 ease were getting better, 2 cases died of heart failure,2 cases died of lung infectious, 1 ease died of multiple system organ failure, 1 case abandoned treatments. Conclusion Neuropsyehic symptom in end-stage uremia was related to multiple factors.Seizure is one frequent side symptom,the key of rescue uremic encephalopathy is early in time blood dialysis filter(HDF).