With the development of molecular biology,the treatment of breast cancer is entering the era of molecular therapy.In order to provide more effective individualized treatment to patients,researchers are finding some new therapeutic targets,new indicators of disease surveillance,new prediction indicators of treatment efficacy and indicators of prognostic evaluation for breast cancer patients.The increasingly in-depth studies have shown that a very important value for the detection of serum tumor markers and circulating tumor cells in breast cancer treatment.In this paper,a series of clinical studies on serum tumor markers and circulating tumor cells in breast cancer were reviewed.