Objective To establish a method for simultaneous determination of 13 components in Jieyu Anshen granules by quantitative analysis of multi components by single marker(QAMS),and to construct its comprehensive quality evaluation model.Methods The mobile phase was acetonitrile-0.1%phosphoric acid,the contents of regaloside C,regaloside E,regaloside B,gardenoside,geniposide,spinosin,jujuboside A,jujuboside B,saikosaponin a,saikosaponin d,bisdemethoxycurcumin,desmethoxycurcumin and curcumin in Jieyu Anshen granules were determined.Orthogonal partial least squares-discriminant analysis(OPLS-DA)and entropy weight-technique for order preference by similarity to an ideal solution(EW-TOPSIS)methods were used for comprehensive quality evaluation.Results The methodological verification met the requirements of Chinese Pharmacopoeia.The orthogonal partial least squares-discriminant analysis(OPLS-DA)showed that geniposide,yayoisaponin d,regaloside B,curcumin,spinosin and saikosaponin a were the main factors for the quality difference of Jieyu Anshen granules.The EW-TOPSIS method showed that the average values of Ci of 14 batches of samples were 0.284 9-0.640 7.Conclusion The established method can be used for the quality control and overall evaluation of Jieyu Anshen granules.