1.How to carry out the translational medicine research effectively in gastrointestinal tumors.
Chinese Journal of Gastrointestinal Surgery 2013;16(1):1-3
As a new concept, the definition of translational medicine remains obscure. The translational medicine connects the bench to bedside, and its importance would be more remarkable. The development of gastrointestinal surgery reflects the idea of translational medicine. To carry out the translational study, the gastrointestinal surgeon must learn how to find subjects from clinical problems, how to collect complete information and tissues, how to collect complete information and tissues, how to collaborate with others from different fields and how to utilize all kinds of resources. By translational studies, gastrointestinal surgeons may further improve the survival of patients with gastrointestinal tumor.
Gastrointestinal Neoplasms
;
Humans
;
Translational Medical Research
4.One case of nasal septum chordoma.
Yan LIU ; Xin-yi LIU ; Xiao-feng ZHANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2012;47(6):514-515
Adult
;
Chordoma
;
Humans
;
Male
;
Nasal Septum
;
pathology
;
Nose Neoplasms
5.Application of robotic system in gastrointestinal surgery.
Xin-Yu QIN ; Feng-Lin LIU ; Yi-Hong SUN
Chinese Journal of Gastrointestinal Surgery 2011;14(5):311-313
Robotic system helps surgeons in performing surgery. Currently Da Vinci system is the most popular. Da Vinci system has been used for the stomach and bowel diseases in 27 cases(18 cases of stomach and 9 cases of colon and rectum) in the Zhongshan Hospital, Fudan University. Accurate preoperative staging is crucial, and Da Vinci system is advantageous in lymph node dissection, preservation of nerve plexus, and complete resection of mesorectum. Adoption of gastrointestinal tract reconstruction technique should depend on the operation and experience in surgery. Though Da Vinci system has limitations and the cost is high, it is believed to be the future trend.
Digestive System Surgical Procedures
;
methods
;
Humans
;
Robotics
;
methods
8.Injury in myocardial cells induced by citreoviridin.
Mi-feng LIU ; Xin JIANG ; Hong-ju YAO
Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(3):177-178
Animals
;
Apoptosis
;
drug effects
;
Aurovertins
;
toxicity
;
Cells, Cultured
;
DNA Damage
;
drug effects
;
Female
;
Male
;
Myocytes, Cardiac
;
drug effects
;
Rats
;
Rats, Wistar
9.Application of array-based comparative genomic hybridization in primary amenorrhea women
Qiong FENG ; Fang FU ; Can LIAO ; Xin YANG ; Liang ZHANG ; Feng TIAN ; Bin CAI ; Shuai LIU
Chinese Journal of Laboratory Medicine 2010;33(11):1079-1082
Objective To explore the molecular mechanisms of primary amenorrhea by using arrayCGH technology. Methods Ten patients with primary amenorrhea and 10 female volunteers with regular menstrual cycles as healthy controls were selected. All patients and control samples were analyzed by conventional chromosome analysis (G-banding technology) and array-CGH technology, respectively. ArrayCGH was performed using Affymetrix Cytogenetic 2. 7M arrays following the manufacturer's standard protocol. Results Both the patient group and control group analyzed by conventional G-banding karyotype technology showed a negative result with a normal female karyotype: 46, XX. The result of array-CGH analysis demonstrated a microdeletion of approximately 110 000 bp located at the end of the short arm of X chromosome [46, X, del (X) (p22. 33 )] were identified in 5 patients, which was not detected in the control group. All healthy control samples by array-CGH analysis showed no pathological DNA copy number variation. Conclusions Array-CGH technology can improve the diagnosis rate of chromosomal disease at the DNA level. It is necessary to provide array-CGH for higher resolution genetic analysis of idiopathic primary amenorrhea patient who can not be identified by conventional technology.
10.Pulmonary infections after kidney transplantation:analysis of CT findings
Feng XUE ; Shiyuan LIU ; Li LI ; Xin GAO ; Kai LIU ; Huimin LI
Chinese Journal of Radiology 2009;43(1):12-16
Objective To review the CT findings in patients with pulmonary infection after kidney transplantation and to determine the characteristic features in different infections.Methods The medical records were reviewed in 446 patients with pulmonary infection after kidney transplantation and 121 patients who had pulmonary thin-section CT were included in this study.The pattern and distribution of the pulmonary abnormalities were interpreted independently by two thoracic radiologists.Statistical analysis was performed using the X2 test and the Fisher's exact teat.Results (1)Time course:65(14.6/) patients initially had pulmonary infection in the first 30 days,147(32.9/)between 1 and 3 months,91(20.4/)between 3 and 6 months,23(5.2/)between 6 and 12 months,120(26.9/)afler 12 months of transplantation.In the first month after procedure,bacterial infection(4/5,80.0/)was the most common infection,bacterial(34/41,82.9/)、mixed(19/41,46.3/)and virus infections(11/41.26.8/)were seen commonly 1 to 6 months following transplant,the incidence of fungal(14/38,36.8/)and myeobaeterial(5/38,1 3.2/)infections was increased after 1 2 months of transplantation.(2)Pathogens:Baeterial(34,28/)and mixed infections(34,28/)were the most common,followed by fungus infeetion(9.7/),TB(7,6/)and eytomegalovirus(5,4/).(3)CT findings:Ground-galss attenuations(69,57.0/)was the most common findings of pneumonia,followed by reticular or linear opacities(68,56.2/),nodules (66,54.5/),pleural thickening(41,33.9/),consolidations(31,25.6/),tree-in-bud patterns(24,19.8/),pleural effusion(22,18.2/),and bronchovascular bundle thickening(16,13.2/).Ground-glass attenuation was commonly seen in cytomegalovirus pneumonia (4,80.0/),and nodule was commonly observed in bacterial infection(23.67.6/),tree-in-bud pattern was the most common finding in pulmonary tuberculosis (4.P=0.049).There were no statistically significant difierences in the prevalence of other CT paRerns (P>0.05).Conclusions The peak incidence of pulmonary infection is in the 3 month after renal transplantation and bacterial infection is the most common.The CT diagnosis of infeetion can be made by combining the time course of infection,clinical laboratory data and lesion distribution.