Serious and/or continuous cerebral hemodynamics disorder is the main cause of neonatal brain injury.Monitoring its changes by using simple,accurate and effective techniques has guiding significances in maintaining the stability of neonatal cerebral hemodynamics.This paper aims to introduce several cerebral hemodynamic monitoring techniques,including color Doppler ultrasound,near infrared spectroscopy,noninvasive magnetic resonance imaging,and provide references to the clinical application in neonatal field.

Objective To investigate the clinical value of the optical microscope on the quality control of the coagulation specimen microscopic examination before the coagulation test.Methods 92 patients with coagulation specimens agglutination occurs which taken were selected as the experimental group,92 patients re-blood microscopy to ensure that no agglutination phenomenon was set to control,observed differences in coagulation indexes of the two groups.Results The PT,APTT,TT and Fg were statistically significant(P ＜ 0.05) between experimental group and control group by the q test.Different agglutination specimens group in the experimental group by analysis of variance,PT,APTT.TT and Fg were statistically significant(P ＜ 0.05) between groups comparison of the q test analysis,PT,APTT,TT and Fg were significant differences (P ＜ 0.05).With the aggravation of blood specimens agglutination,PT,APTT and TT time extension and Fg concentration reduce more serious.Conclusion Optical microscope before the introduction of clotting function tests experimental quality control a large extent,to enhance the accuracy of laboratory coagulation test results,clinical diagnosis and preoperative preparation has important clinical value.

Neurofeedback as a behavior therapy measurement for ADHD has gained increasing attention in recent years.Based on researches have been published of neurofeedback in ADHD in nearly 5 years,the researches development of neurofeedback are reviewed.The data showed that TBR,SMR and SCP neurofeedback are clinically effective treatment for ADHD.Future controlled clinical trials should focus on such known protocols for specific research,and be designed in line with learning theory.

Objective To explore the effect of protocatechuic acid on serum tumor necrosis factor-α( TNF-α) , interleukin-1β( IL-1β) and oxidative stress products levels in Parkinson rats.Methods 60 male SD rats were randomly divided into normal control group ( n=10 ) , model group (n=10), madopar group (n=20) and protocatechuic acid group (n=20).Rat model with Parkinson disease were builded in model group, madopar group and protocatechuic acid group.Madopar group and protocatechuic acid group were given corresponding drug with a consecutive treatment of two weeks.After treatment,the serum TNF-α,malondialdehyde (MDA), superoxide dismutase (SOD) and IL-1βlevels were detected in all groups.Results Compared with normal control group, the serum TNF-α, IL-1βand MDA levels in model group were significantly higher, and SOD level was lower (P<0.05).Compared with model group, the serum TNF-α, IL-1βand MDA levels in madopar group pre-treatment were significantly lower, and SOD level was higher (P<0.05).There were no significant difference of serum TNF-α, IL-1β, MDA and SOD levels between madopar group and protocatechuic acid group.Conclusion The protocatechuic acid could significantly reduce the serum TNF-α, MDA and IL-1βlevels in Parkinson model rats, enhance the activity of SOD, which has protective effect on oxidative stress injury induced by Parkinson disease.

Objective:To review the research hotspots and evolution of electroencephalogram (EEG) biofeedback in attention-deficit/hyperactivity disorder (ADHD) by knowledge mapping software.Methods:Based on web of science core collection database,we searched the literature with keywords (EEG biofeedback OR neurofeedback) AND (ADHD OR attention-deficit/hyperactivity disorder) in topic and time limit set before December 31,2015.319 literature were accepted,using the CiteSpace to depict the hot keywords,cited references and countries.Results:United States of America,Germany,Netherlands were top 3 countries in publishing papers of EEG biofeedback in ADHD.Based on burst of cited references,the research evolution of EEG biofeedback in ADHD could be divided into three stages.The hotspots of EEG biofeedback in ADHD were Slow Cortical Potentials protocol and double-blind placebo-controlled study.Conclusion:Future research should focus on the mechanism of EEG biofeedback and such known protocols for individualized treatment,or be designed along the lines of learning theory.

Animals ; Hippocampus ; metabolism ; Long-Term Potentiation ; Male ; Neurogranin ; biosynthesis ; Rats ; Rats, Wistar ; Sleep Deprivation ; metabolism

Objective To explore the auxiliary effect of ultrasonic guidance for percutaneous transhepatic varices embolization ( PTVE) for the treatment of hemorrhage of upper gastrointestinal with cirrhosis. Methods Fifty-two patients arranged PTVE by ultrasonic guidance were considered as observation group,and 37 patients arranged PTVE by blind paracentesis were considered as control group. The paracentesis success ratio,time of paracentesis,results and rate of complications in the two groups were compared. Results The achievement ratio of one-time puncture in observation group(73. 1%) was significantly increased than that in control group(43. 25). The differences were statistically significant(P<0. 05). The time of paracentesis in observation group (2. 3±0. 6) min was shorter than that in control group(4. 2±0. 8) min. The differences were statistically significant(P<0. 05). The rate of embolization rate in observation group(100%) was obviously higher than that in control group(86. 5%),the differences were statistically significant(P<0. 05),and the rate of complications was less than that in control group. Conclusion The ultrasonic guidance plays an important assistant roles for PTVE,it is helpful to determine the location of portal vein and increase the paracentesis succeed ratio and speed. It is safe and deserved to be spread.

[Objective]To investigate the effects of alendronate(ALN)on subchondral bone and articular cartilage in the rat osteoarthritis model induced by anterior cruciate ligament transaction(ACLT).[Method]Twenty-four three-month-old female Sprague-Dawley rats were divided randomly into three groups:Sham group(n=8),ACLT+NS group(n=8) and ACLT+ALN group(n=8)(20 ?g?kg-1?2 d-1 subcutaneous injection for 12 weeks).Bone mineral density(BMD) measurement and bone histomorphometric analysis were made for the subchondral bone of right distal femur and proximal tibia in all rats at 12 weeks post surgery.Degree of cartilage degeneration was scored by Mankin scoring system.Immunostaining for matrix metalloproteinase 13(MMP-13) was performed to investigate the effect of ALN on cartilage matrix loss.[Result]BMD of the subchondral bone in the ACLT+NS group were significantly lower than those in the Sham group and the ACLT+ALN group(P

The present study on 24 cases disclosed that the erythrocyte deformability(ED) of patients with acute myocardial infarction (AMI) was significantly lower than normal control. After incubate the patients' erythrocyte with Prop-lene Glycol Mannituse Sulfate(PGMS) and Pro-plene Glycol Alginate Sudium Sulfate (PSS ) , The ED was significantly higher than that of in-cubated without drug. PGMS was more effi-cious. The result indicated that PGMS and PSS may have high value in improving the microcir-culation of patient with AMI, increasing the blood flow of capilliaries in ischemic myocardium and reducing the area of infarction.

Five-zang is the nucleus of viscera state doctrine. The nonequilibrium of Five-zang's different properties guides syndrome differentiation and treatment in TCM. This article discusses five-zang's nonequilibrium from lung being a delicate viscus,correlation between lung and five-zang,physiology and pathology of lung and so on. It attaches the importance to five-zang's nonequilibrium and clinical level of syndrome differentiation.