Serious and/or continuous cerebral hemodynamics disorder is the main cause of neonatal brain injury.Monitoring its changes by using simple,accurate and effective techniques has guiding significances in maintaining the stability of neonatal cerebral hemodynamics.This paper aims to introduce several cerebral hemodynamic monitoring techniques,including color Doppler ultrasound,near infrared spectroscopy,noninvasive magnetic resonance imaging,and provide references to the clinical application in neonatal field.

Objective To investigate the clinical value of the optical microscope on the quality control of the coagulation specimen microscopic examination before the coagulation test.Methods 92 patients with coagulation specimens agglutination occurs which taken were selected as the experimental group,92 patients re-blood microscopy to ensure that no agglutination phenomenon was set to control,observed differences in coagulation indexes of the two groups.Results The PT,APTT,TT and Fg were statistically significant(P ＜ 0.05) between experimental group and control group by the q test.Different agglutination specimens group in the experimental group by analysis of variance,PT,APTT.TT and Fg were statistically significant(P ＜ 0.05) between groups comparison of the q test analysis,PT,APTT,TT and Fg were significant differences (P ＜ 0.05).With the aggravation of blood specimens agglutination,PT,APTT and TT time extension and Fg concentration reduce more serious.Conclusion Optical microscope before the introduction of clotting function tests experimental quality control a large extent,to enhance the accuracy of laboratory coagulation test results,clinical diagnosis and preoperative preparation has important clinical value.

Neurofeedback as a behavior therapy measurement for ADHD has gained increasing attention in recent years.Based on researches have been published of neurofeedback in ADHD in nearly 5 years,the researches development of neurofeedback are reviewed.The data showed that TBR,SMR and SCP neurofeedback are clinically effective treatment for ADHD.Future controlled clinical trials should focus on such known protocols for specific research,and be designed in line with learning theory.

Objective To explore the effect of protocatechuic acid on serum tumor necrosis factor-α( TNF-α) , interleukin-1β( IL-1β) and oxidative stress products levels in Parkinson rats.Methods 60 male SD rats were randomly divided into normal control group ( n=10 ) , model group (n=10), madopar group (n=20) and protocatechuic acid group (n=20).Rat model with Parkinson disease were builded in model group, madopar group and protocatechuic acid group.Madopar group and protocatechuic acid group were given corresponding drug with a consecutive treatment of two weeks.After treatment,the serum TNF-α,malondialdehyde (MDA), superoxide dismutase (SOD) and IL-1βlevels were detected in all groups.Results Compared with normal control group, the serum TNF-α, IL-1βand MDA levels in model group were significantly higher, and SOD level was lower (P<0.05).Compared with model group, the serum TNF-α, IL-1βand MDA levels in madopar group pre-treatment were significantly lower, and SOD level was higher (P<0.05).There were no significant difference of serum TNF-α, IL-1β, MDA and SOD levels between madopar group and protocatechuic acid group.Conclusion The protocatechuic acid could significantly reduce the serum TNF-α, MDA and IL-1βlevels in Parkinson model rats, enhance the activity of SOD, which has protective effect on oxidative stress injury induced by Parkinson disease.

Objective:To review the research hotspots and evolution of electroencephalogram (EEG) biofeedback in attention-deficit/hyperactivity disorder (ADHD) by knowledge mapping software.Methods:Based on web of science core collection database,we searched the literature with keywords (EEG biofeedback OR neurofeedback) AND (ADHD OR attention-deficit/hyperactivity disorder) in topic and time limit set before December 31,2015.319 literature were accepted,using the CiteSpace to depict the hot keywords,cited references and countries.Results:United States of America,Germany,Netherlands were top 3 countries in publishing papers of EEG biofeedback in ADHD.Based on burst of cited references,the research evolution of EEG biofeedback in ADHD could be divided into three stages.The hotspots of EEG biofeedback in ADHD were Slow Cortical Potentials protocol and double-blind placebo-controlled study.Conclusion:Future research should focus on the mechanism of EEG biofeedback and such known protocols for individualized treatment,or be designed along the lines of learning theory.

Objective To investigate the early influences of laser photocoagulation on macular retinal thickness in diabetic retinopathy(DR). Methods Optic coherence tomography examination was performed in 30 eyes with DR(phase Ⅲ~Ⅳ) before, and on the 3rd day and the 7th day after photocoagulation respectively. The thickness of neuroretina and pigment epithelium were measured in the areas of fovea macula and 750 ?m from fovea macula. Results Three days after photocoagulation, significant thickening of neuroretina was observed in the fovea macula, which is positively related with age, fasting blood sugar and duration of DR. There was no significant changes in the thickness of pigment epithelium in macula and in the thickness of neuroretina 750 ?m from fovea macula. Conclusion Significant thickening of neuroretina in fovea macula in DR early after photocoagulation reveals progressed macular edema induced by photocoagulation which is positively related with age, fasting blood sugar and duration of DR.

Five-zang is the nucleus of viscera state doctrine. The nonequilibrium of Five-zang's different properties guides syndrome differentiation and treatment in TCM. This article discusses five-zang's nonequilibrium from lung being a delicate viscus,correlation between lung and five-zang,physiology and pathology of lung and so on. It attaches the importance to five-zang's nonequilibrium and clinical level of syndrome differentiation.

Objective To study the relationship between expression of Fas ligand (FasL) in colorectal cancer tissues and apoptosis of tumor-infiltrating lymphocytes (TIL). Methods FasL protein and its mRNA were measured by immunohistochem istry and in situ hybridization in the consecutive tissue slices of 30 colorecta l cancers respectively. Immunohistochemistry and terminal deoxynucleotidyl tra nsferase mediated dUTP nick end labeling assay (TUNEL) were used to detect the cell count of TIL and the count of TIL being apoptosis in both negative and pos i tive regions of FasL in the consecutive tissue slices of cancers respectively. T UN EL method was used to detect apoptosis of tumor cells among different FasL expre ssion regions. Results ①High expression of FasL was examined in 30 cases of colo rectal cancer; there were expressions of FasL in more than 75% tissues in each slice. ②In the consecutive tissue slices, the location of expression of FasL protein corresponded with that of FasL mRNA. ③FasL expression was not eve n in the same or among different tissues. The cell count of TIL was less in FasL positive region than that in FasL negative region in the same tissue, the latt er be ing as 2.88 times as the former. ④ The cell count of TIL being apoptotic in the positive regions was as 2.13 times as that in the negative ones. ⑤ Apoptotic r ate of tumor cells was higher in FasL negative region (81.2%) than that in FasL positive region (47.4%, P

This paper would review the experimental research over acupuncture associated with milieu therapy towards neonatal rats with hypoxic-ischemic brain damage during the past decade, while focus on exploring the therapeutical mechanism of acupuncture and rehabilitation for cerebral palsy.

Objective　To evaluate the result of unilateral ex ploration for the treatment of hyperparathyroidism caused by parathyroid adeno ma.　Methods　Clinical data of 20 case s from 1986 to 1999 were retrospectively analysed. Preoperative imaging examinat ion was suggestive of unilateral lesion and unilateral exploration was performed accordingly.Results were compared with that of bilateral exploration.　Results　In 19 out of 20 cases the result of u nilateral exploration was satisfactory making bilateral approach unnecessary exc ept for one whose symptom was later proved to be caused by bilateral lesions.Conclusions　The authors came to the c onclusi on that solitary adenoma is the most common cause of hyperparathyroidism in Chin ese patients,hence unilateral exploration is of advantages.