Objective To discuss the influence of Doula delivery and non -Doula delivery on cesarean section(CS)morbidity. Methods796 cases with Doula delivery and 800 cases with non-Doula delivery were compared in CS morbidity, CS causes, dystocia morbidity in vaginal delivery and neonatal distress. ResultsThe main causes of CS in both groups were fetal distress, fetal malposition and cephalopelvic disproportion and uterine inertia (problems of"power"), The CS morbidity in Doula delivery group(24.37%) was significantly lower than that in non-Doula group(38.25%) (P<0.01). In Doula delivery, CS due to uterine inertia was significantly less than that in non-Doula delivery (P<0.05). However, CS rate due to fetal distress was higher in the former group (P<0.05). In the vaginal delivery cases of the two groups, dystocia morbidity in Doula delivery group(6.00%) was statistically lower than that in non-Doula delivery group(9.72%) (P<0.05). The rates of neonatal distress in the two groups were not significantly different (P>0.05). ConclusionDoula delivery can decrease the CS morbidity without increasing the rate of neonatal distress. Therefore, Doula delivery is worth administering in clinical practice.

Animal models are very important tools to study the pathogenesis,pathology and treatment of atherosclerosis.Animal models for studying atherosclerosis include rodents,rabbits,pigs and nonhuman primates.Among them,ApoE-/-mouse and LDLR-/-mouse are currently the most widely used.They can form atherosclerotic lesions,but in some respects there are significant differences.In this paper,the differences between the two model mice in lipid metabolism,plaque formation and pathology,lymphocytes,macrophages,dendritic cells,microRNA expression and regulation were reviewed.

Objective To evaluate the clinical factors correlated to eclampsia.MethodsPregnant women with pregnancy－ induced hypertension syndrome (PIH) in 5 years were retrospectiv-ely studied. The relations between eclampsia and prenatal care, PIH degree and the dose of magnesiumsulphate used were evaluated, as well as the eclarnptic aural symptoms and their occurring time. Re-sults The incidence of eclampsia in pregnant women was 0.56 %, and 8.33 % in the PIH cases. Eclamp-sia was significantly correlated to antenatal care. The incidence of eclempsia in cases with moderate andsevere PIH were higher than that with wild PIH. Less than 15g magnesium sulphate (MgSO4) used perday in moderate and severe PIH cases had an eclampsia incidence rate as high as 20.00 %. And the inci-dence in the mild PIH cases was comparatively lower, but still as high as 6.19%. Aural symptoms al-ways appeared prior to eclampsia. Almost all eclampsia cases had the aura within 24h prior to the attack.ConclusionProper and effective antenatal care was of great importance in the prevention of the eclamp-sia. In moderate and severe PIH the eclampsia incidence was higher, but could be decreased by the pro-per use and sufficient amount of MgSO4. It should be emphasized that mild PIH could still develop intoeclampsia. All eclampsia cases had aura which must be paid attention to in PIH cases.

Objective: To investigate the effect of different analgesia methods on blood coagulation in patients who underwent esophageal carcinoma surgery through thrombelastography (TEG). Methods:A total of 60 patients who underwent radical esophagecto-my were randomly divided into the patient-controlled epidural analgesia (PCEA) group and patient-controlled intravenous analgesia (PCIA) group with 30 cases each. The visual analogue scale (VAS) and patient-controlled analgesia (PCA) bottom pressing times were recorded at 6, 12, 24, and 48 h after surgery. The TEG parameters were measured at the time before anesthesia (T0), the end of surgery (T1), first day after operation (T2), second day after operation (T3), and third day after operation (T4). Results:(1) Compared with the PCIA group, the VAS scores and PCA bottom pressing times were significantly lower (P<0.05). (2) The R and K values of the PCEA group had no significant difference compared with T0 (P>0.05), and were significantly prolonged than those in the PCIA group at T2, T3, and T4 (P<0.05). (3) The platelet amount of the two groups decreased at T2 and T3 compared with that at T0 (P<0.05). Conclu-sion:The analgesic effect of PCEA was better than that of PCIA in patients who underwent esophageal carcinoma surgery, and may im-prove their hypercoagulability.

Radiotherapy is a primary treatment for lung cancer, especially for non-small cell lung cancer (NSCLC). Compared with conventional fractionated radiotherapy, hypofractionated radiotherapy (HFRT) is a powerful method in NSCLC treatment because of its convenience and excellent clinical efficacy. Although HFRT has been significantly developed for treating NSCLC, radiation resistance with an unknown molecular mechanism is still observed in tumors. The PI3K/AKT/mTOR signaling pathway significantly affects resistance to conventional fractionated radiotherapy. However, whether this pathway induces radiation resistance to HFRT remains unclear. The underlying molecular mechanisms between HFRT and the PI3K/AKT/mTOR signal pathway may be used as targets in radiation sensitivity or in the modification of radiation resistance in NSCLC patients. New predictive biomarkers can also be expected in the PI3K/AKT/mTOR signaling pathway when the clinical specimen is screened using HFRT.

A briefly introduction of action mechanism of preservatives,deterioration caused by microorganism and the commonly used preservatives in cosmetics were presented in this paper. Sample pretreatment method and instrumental analysis method were summarized also. The popular preservatives in cosmetics were parabens. The consumption of new preservatives in cosmetics (iodopropynyl butylcarbamate,diazolidinyl urea,imidazolidinyl urea) is increasing. The analysis method of preservatives by the high-performance liquid chromatography was most widespread. Regarding kathon,the sensitivity of gas chromatography is higher than that of high-performance liquid chromatography. The other analysis methods are semi-quantitative thin layer chromatography and simultaneously determination water-soluble and the fat soluble preservatives capillary electrophoresis. The methods for determination of 55 limited preservatives of Hygienic Standard for Cosmetics(in 2002 version) are still not satisfactory,more methods should be developed.

Breast-conserving surgery (BCS) has become the most common treatment for breast ductal carcinoma in situ (DCIS).BCS followed by radiotherapy (RT) can reduce the risk of recurrence.However,controversy exists regarding the region of RT,which low-risk patients can avoid RT after BCS,and the role of accelerated partial breast irradiation (APBI) in the treatment of BCS.However,most trials have indicated that all DCIS patients can obtain benefit from RT after BCS.Further prospective studies are warranted to identify whether RT can be safely omitted for low-risk patients with DCIS.Long-term results of ongoing studies on outcome of BCS alone suggest that RT should be routinely recommended after BCS for all patients except those with contraindication.

Objective To summarize the characteristics of images and clinical diagnosis of bladdernon-epithelial tumors,and to investigate the relationship between the therapeutic methods and prognosis of thedisease. Methods The clinical data of 25 patients (16 males and 9 females,aged between 2 -71 years)with bladder non-epithelial tumors treated in our hospital were retrospectively analyzed.The clinical manifes-tations included hematuria (6 patients),lower abdominal lump (2),frequent urination (14),dysuria (2)and fainting during voiding (1).Ultrasound and CT examinations suggested space-occupying lesions in thebladder in 22 patients and pelvic tumor involving the bladder wall in the other3 patients.Cystoscopy was per-formed in all patients and 17 patients got biopsy. Results Simple tumor resection or partial cystectomywas carried out in 15 patients with benign tumors;the rest 10 patients with malignant tumors underwent par-tial or radical cystectomy. Adjuvant radiotherapy and chemotherapy were performed in malignant tumor pa-tients.Follow-up time was 3 months to 11years.No recurrence was found in benign tumor patients.Nine pa-tients with malignant tumors died in 3 years after operation (mean survival time of 16 months).A patientwith bladder malignant lymphoma survived for6 years.Three recurrences occurred in another bladder leiomy-osarcoma patient who had tumor resection. Conclusions Bladder non-epithelial tumors are relatively rarein clinical.The pathological types of the tumors are complicated,most of them are malignant and the progno-sis is relatively poor.The clinical perception of these tumors is inadequate and misdiagnosis rate is high.Deep-site biopsy under cystoscope can improve the diagnostic rate.Partial or radical cystectomy is the maintherapy for these tumors,and adjuvant radiotherapy and chemotherapy can be used according to the pathologi-cal features, but the effects are uncertain and the prognosis is quite different.

ObjectiveTo explore methods and prevent complication with transection and intra fixation of breastbone and costa to treat pectus excavatum in children. Methods35 cases cured with transection and intra fixation of breastbone and costa to treat pectus excavatum were analyzed. Results35 cases have good contours in one operation. 1 case's pleurisy was wounded slightly. 2 case complicated with lung infection. Conclusionstransection and intra fixation of breastbone and costa is a simple methods to treat pectus excavatum in children and it has little complication..It's orthopaedic is obvious. It is worth to spread.

Objective: To study the dosage application of herbs in class formulas of KaixinSan recorded in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy (Taiping Huimin Hejiju Fang), Essential Recipes for Emergent Use Worth A Thousand Gold (Beiji Qianjin Yao Fang) and Records of Approved Cases of Ancient and Recent Times (Gujin Luyan) and their actions on depression. Method: According to the dosage proportion of different herbs in the three formulas in the three books, two methods were adopted in terms of decocting different herbs separately and mixing them thereafter(group of decocting separately) as well as extracting after decocted all the herbs together (group of decocting together). Classical anti-depression mice models--forced swimming and tail suspending experiments were observed. The data of immovability time of mice were analyzed by statistics. Result: All the class formulas of KaixinSan which have the same medication but different proportion in the three medical books can reduce the immovability time of mice in forced swimming and tail suspending experiments. But the action of KaixinSan recorded in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy was prominent, and the action of the group of decocting together was superior to that of separated decocting. There was significant difference between the group of decocting together in low dosage and the controlled one (P