may sever as an indicator for the progression of malignant melanoma.

The fetal stage is a critical period for brain development. Intrauterine growth restriction(IUGR)af-fects the growth of fetus and impairs the brain development severely,resulting in long - term neurological sequelae such as motor and behavioral disorders. Since their brain underdevelopment originated in the uterus,postnatal interventions usually fail to improve the brain function. Then antenatal interventions become urgent to protect the brain,taurine has appeared a high practical value in improving the brain development. The adverse effects of IUGR on fetal brain develop-ment and the possibilities of antenatal interventions were introduced in this paper in order to improve the prognosis of the nervous system.

The clinical probation is an important part of medical education, which is also a bridge from theoretical learning to clinic practice. To improve the quality of clinical probation teaching of hematology department, multiple teaching activities have been carried out, including full preparation before teaching, creating better medical environment, arousing enthusiasm, tralning the physician-patient communication ability and strengthening operating skill of the students. Good study effect has been achieved.

Mammalian gonadotropin-releasing hormone(termed GnRHⅠ) is a decapeptide that plays key role in the process of reproduction.In addition to its well-known endocrine function, it has become evident that GnRHⅠ and the second GnRH subtype(termed GnRHⅡ) are potentially important autocrine and/or paracrine regulators in placental trophoblast cells.The effects of GnRHⅠ and GnRHⅡ on trophoblastic cell invasion were investigated in human choriocarcinoma cell line(JEG-3) by the methods of invasion assay, RNA interference, Western blot and Real-time PCR.The data revealed that exogenous native peptide of these two forms of GnRH significantly induced the expression of typeⅠ GnRH receptor(GnRHRⅠ) in JEG-3 cells.The specific siRNA for GnRHR Ⅰ was capable of blocking the invasion-promoting effect of GnRHⅠ, but did not influence the effect of GnRHⅡ.The data suggested that the two hormones may be elicited by distinct receptors.Interference of the activities of ERK and JNK was capable of attenuating GnRH Ⅰ and Ⅱ-induced MMP-2 expression and trophoblast invasion, indicating that activation of ERK and JNK are required in both GnRH Ⅰ and GnRH Ⅱ-mediated MMP-2 production and invasion-promoting effect in human trophoblastic cells.

Objective To compare the effects of Chinese herbal fumigation and ultraviolet light exposure on air disinfection in neurosurgical intensive care unit.Methods The floors and the tables in the rooms of ICU were all disinfected using 0.02%84 disinfectant.The air disinfection was performed in the rooms using Chinese herbal(elsholtziae,ramulus cinnamomi,forsythia suspense,flos caryophylli)fumigation as the experiment group and those using ultraviolet light exposure as the control group,both for 30 times.The two disinfection methods were compared before air disinfection,at hours 0,1,2,4,8 and 12 in terms of bacteria tests.Results The air quality on natural bacteria in both groups met the standard of Class Ⅱ Environmental Health Criteria at hour 0,l after air disinfection,without significant difference between the two groups at each time point(P>0.05).In the control group,the bacteria began to grow in number one hour after ultraviolet light exposure and overgrew two hours after air disinfection.In the experiment group,the bacteria grew less,never exceeding the standard level at all time points.The disinfection effect of the experimental group was all significantly better than that of the control group at the time points of 2 h,4 h,8 h,12 h(P<0.05 or P<0.01). Conclusions Chinese herbal fumigation is superior to the UV light irradiation disinfection.It is safe and harmless even in case of medical staff working in the unit.

The regeneration of neurons are very weak after the central nervous system is injured,the lack of growth factors in the internal environment and the existence of various inhibitors in the microenvironment are main reasons. Rho-ROCK signaling pathway mediates inhibitory signals to prevent regeneration of nerve cells in the central nervous system. In this paper,the advances in the research on biological property and regulation and interventions of Rho-ROCK signaling pathway are reviewed.

Objectives: To test whether early prophylactic antidepressant treatment by paroxetine has any beneficial influence on the rate of post-stroke depression (PSD) and rehabilitation of stroke patients. Methods: A randomized, placebo controlled study involved 64 consecutive patients admitted to hospital for an acute stroke; they were treated with placebo, paroxetine (20mg/d) respectively. Before and at the end of the observation, we assessed the rate of PSD and activities of daily living (ADL), degree of neurological deficit (modified Edinburgh-Scandinavia scale, MESS) of all the subjects.Results:At the end of 12-week treatment, the treatment group had lower rate of PSD (10.7%) than control (41.4%); and they had lower score in ADL (27.6?4.8/32.8?4.1) and lower score in MESS (11.1?4.3/13.6?3.2).Conclusion:Prophylactic antidepressant treatment by paroxetine can decrease the rate of PSD and improve the neurological function of post-stroke patients.

Data quality issues of TCM structured data warehouse system is very important.This paper analyzed the data quality issues from the data repository to the data extraction,cleansing,transformation,loading (ETL) into the data warehouse process and established the principle of corresponding control,and researched improving data quality measures to ensure the success of data warehouse and right decision support.

Parkinson’s disease (PD)is one of familiar neurodegenerative disorder. The pathogenesis of PD,up to now,has not been fully understood. Although heredity,aging and environmental factors were involved,the combination effects of these factors were much concerned. PD animal model is an indispensable tool for exploring the mechanism,neuro-protective drugs and therapy strategies. Some kinds of animal models were introduced in this paper. MPTP mouse model is the most important and most universal use.The consideration of the effect of multiple risk factors may be the start of new era in the research field of PD animal models.