Objective:To investigate the methods of seamless integration between supplies management system for orthopedic implant consumables and HIS, and realize real-time dynamic monitoring of orthopedics implant material.Methods: After full investigation and process reengineering, we have carried out the dictionary to reconsider and code corresponding to orthopedic implant consumables, by implementing integration with HIS, successfully establishing the real-time dynamic supervision mode of orthopedics implant material.Results: Two systems have completed seamless integration, and safely use more than three years with remarkable application results.Conclusion: We make the successful innovation of advanced management ideas combined with information technology, to solve the problem of orthopedic implant consumables management and provide adequate protection to continuously improve the level of medical safety and quality management.

End-tidal carbon dioxide tension or concentration monitoring is characterized with noninvasive,convenient and fast reaction,which Can be continuously monitored and dynamically displayed On electrocardiogram monitor.The technique has been extensively applied in the operation room,intensive care unit and emergency room.

Objective To evaluate the efficacy of stellate ganglion block ( SGB) in the treatment of ischemic optic neuropathy ( ION ) as compared with that of steroids. Methods Eighty-two eyes were involved in seventy patients with ION. The patients were randomly assigned to receive either steroids (dexamethason 15 mg iv q.d. for 5-10 days followed by peroral prednisone 20 mg q.d.) ( n = 34, 38 eyes) or ipsilateral SGB (2% lidocaine 2-3 ml q.d. 10-15 days) ( n = 36, 44 eyes). The criteria for judging the efficacy of the treatment were changes in visual acuity, ocular fundus, visual field and visual evoked potential (VEP) . The effectiveness of the treatment was divided into four grades : excellent, good, improved and no effect. Results In steroid group the results of treatment were rated as excellent for 10, good for 12, improved for 3 and no effect for 13 eyes (the overall success rate was 65.8%), while in SGB group the results were rated as excellent for 15, good for 14, improved for 5 and no effect for 10 eyes ( the overall success rate was 77.3 % ). In patients who were successfully treated, the visual acuity improved, the pale edema of optic papilla was disappearing and the color and blood vessels of retina were returning to normal. The latent time of VEP P100 was significantly shortened and the amplitude increased in both groups. Conclusion SGB is a safe, reliable and effective method of treatment for ION.

Objective:To study the clinical therapeutic effect of acupoint stimulation on obssession.Methods:60 inpatients and outpatients of obsession were divided into two groups,a chlorimipramine group(control group)and an acupoint stimulation plus chlorimipramine group(treatment group),30 cases in each group.Their therapeutic effect and adverse effects were evaluated with Y-BOCS, HAND,BPRS and TESS,respectively.Results:The cured rate and the markedly effective rate were 26.7% and 56.6% in control group and 43.3% and 76.7% in treatment group,respectively,the treatment group being better than the control group.The adverse reactive rate was 73.33% in control group and 46.67% in the treatment group with a significant difference between the two groups(P

Objective To investigate the relationship between molecular biological markers and recombinant human endostatin targeted therapy in non-small-cell lung cancer(NSCLC).Methods 68 cases patients with non-small-cell lung cancer to meet the requirements were randomly divided into group A (n=34)and group B (n=34).Group A received docetaxel and cisplatin(DP)and gefitinib;group B received recombinant human endostatin on the base of group A.The biological markers species,such as,EGFR,KRAS,VEGF,BRCA1,EML4-ALK,ERCC1,β-tubulin and CD3 were detected by immunohistochemical.The types of population for different programs were summarized according to the expression of biological markers and progression free survival (PFS)of the two groups. Results Group B median PFS was significantly longer than that in group A;no matter low or high expression of VEGF and BRCA1,group B median PFS was significantly longer than that in group A(P<0.05);high expression of ERCC1,KRAS,EML4-ALK andβ-tubulin,group B median PFS was significantly longer than that in group A(P<0.05);low expression of EGFR and CD3,group B median PFS was significantly longer than that in group A (P<0.05 ).Conclusion No matter low or high expression of VEGF and BRCA1 ,low expression of KRAS, ERCC1,EML4-ALK and β-tubulin and high expression of EGFR and CD3 in patients with non-small cell lung cancer may be more sensitive to the treatment of DP and gefitinib combined with recombinant human endostatin.

Objective To investigate diagnostic significance of detecting p53 protein in cytologic specimens by endoscopic pancreatic duct brushing for pancreatic cancer. Methods p53 protein in cytologic specimens was detected by immunohistochemistry, and the resules were compared with cytologic specimens by HE staining. Results Sensitivity, specificity, and accuracy of HE staining for pancreatic cancer is 53%, 100% and 70% respectively. Sensitivity, specificity, and accuracy of detecting p53 protein for pancreatic cancer is 59%, 100%, 74% respectively. Sensitivity, specificity, and accuracy of HE staining and detecting p53 protein for pancreatic cancer is 71%, 100%, 81% respectively. Conclusions HE staining combined with detecting p53 protein in cytologic specimens by endoscopic pancreatic duct brushing is a useful stool for diagnosis of pancreatic cancer. It is helpful to differentiate benign diseases of pancreas from malignant tumor of pancreas.

Objective To investigate the clinical, rad iographic and pathological features of intraductal papillary-mucinous tumor of the pancreas(IPMT). Methods The features, imaging manifestation and pathological find ings of 9 patients with IPMT were reviewed. Results There were 6 male and 3 female in this series with ag e ra nging from 37 to 76 years(average 68.4 years). The common complaint was upper ab dominal pain. Most of the tumors located at the head of pancreas. The feature of ERCP findings include dilation of the orifice of the papilla of Vater, swelling of the papilla of Vater, massive mucin production and dilation of main pancreat ic duct. The pathological finding is adenoma or adenocarcinoma. Conclusions IPMT is a kind of pancreatic tumor and its prognosis i s better than pancreatic duct cancer. We should differentiate IPMT from other pa ncreatic tumors.

Objective To investigate the diagnostic value of detecting K ras gene codon 12 mutations in cytologic specimens by endoscopic pancreatic duct brushing for pancreatic cancer. Methods Thirty five patients at Changhai hospital between 1999 and 2001 were enrolled. Cells from pancreatic duct burshings during ERCP were suspended with PBS. DNA of the cells was extracted and K ras gene codon 12 mutations were detected by means of PCR SSCP. Results K ras gene mutation rate of pancreatic cancer was 70%, which was higher than that of chronic pancreatitis (14%, P

AIM: To use the increasing rate of hygroscopic weight added to represent the mechanical properties of microcapsules, and to study the influence of excipients on the mechanical properties of microcapsules. METHODS: To develop a method of processing the microcapsules, which simulates the rubbing, shearing effect on the microcapsules during manufacturing, and calculate the increasing rate of hygroscopic weight added to study the influence of excipients on the mechanical properties. RESULTS: The excipients could affect the mechanical properties of microcapsules. CONCLUSION: The mechanical properties of microcapsules is the important quality standard, We can use it for selecting excipients used for microcapsulation.

Objective In order to study the structure-activity relationship of oridonin,Some derivatives of oridonin were synthesized and their cytotoxicity activity was evaluated.Methods Oridonin (Ⅰ) was isolated and purified by silica gel column chromatography.The derivatives were synthesized from oridonin through oxidation and acylation.All compounds were confirmed by spectrum analyses and their cytotoxicity was evaluated by MTT method.Results Six compounds were obtained and identified as: 14-acetyl-oridonin(Ⅱ),1,14-diacetyl-oridonin(Ⅲ),14-p-tolylsulfonyl-oridonin(Ⅳ),1-oxo-oridonin(Ⅴ),14-acetyl-1-oxo-oridonin(Ⅵ),14-p-tolylsulfonyl-1-oxo-oridonin(Ⅶ).Among them compounds Ⅳ,Ⅵ,and Ⅶ were new compounds.Five compounds showed better cytotoxicity than oridonin.Conclusion The cytotoxicity of 1oxo oridonin derivatives is first evaluated and shows the stronger cytotoxicity than oridonin.