OBJECTIVE:To study the pharmacological actions of compound Yinshen granules(CYSG) on cerebral ischemia injuries in rats METHODS:Using an established middle cerebral artery occlusion(MCAO)model devised by Tamura,we observed infarction areas of the brain and behaviour grade of cerebral apoplexy,and calculated brain water content and brain index RESULTS:CYSG(10 0g/kg,5 0g/kg in rats)significantly reduced infarction areas,ameliorated neurological symptoms,decreased brain water content and brain index after MCAO in rats CONCLUSION:CYSG can protect ischemia cerebral injuries in rats

Chemotherapy has been the cornerstone of cancer treatment for decades. However, albeit remarkable, the response to chemotherapy is generally short-lived. With deepened understanding of cancer immunology, resurgence was recently witnessed in the field of cancer immunotherapy. Unlike chemotherapy, immunotherapy induces a relatively mild but stable response. Accumulating evi-dence reveals that apart from chemotherapy's direct cytotoxic activity, chemotherapy exerts immune-potentiating effects by increas-ing the immunogenicity of tumor cells or by disrupting the tumor-induced immunosuppression and altering the immune microenviron-ment. The latter mechanism serves as the basis for the combined use of chemotherapy and immunotherapy. In this review, we exam-ine the rationale for combinatorial therapy in accordance with the current understanding on tumor immunity and newly discovered im-mune-based chemotherapeutic mechanisms. We further discuss the available preclinical and clinical studies on the combination of chemotherapy and immunotherapy for cancer treatment. We aim to provide a framework for further research.

Objective:To study the clinical characteristics of children with paragonimus pericarditis.Methods:The diagnosis and treatment effect of 43 children with paragonimus pericarditis were retrospectively analysed.Results:There was diversity in the clicinal manifestations.Thirty-four cases were treated with praziquantel,pericardiocentesis,open pericardial drainage and so on.In 30 cases that were followed up,26 cases were cured and 4 cases developed pericardial constriction.Four cases with constrictive pericarditis were cured after pericardiectomy.Conclusion:The children with paragonimus pericarditis could be diagnosed early by careful asking of the case history of eating crabs,routine examination of the numbers of the acidophile in blood and pericardial effusion and paragonimus antigen intracutaneous test.It is possible to develop pericardial constriction after clinical cure in those cases that have had a long course of disease before treatment.

Vasovagal syncope (VVS) although is a benign disease,repeated syncope attacks can reduce quality of life in patients,in some cases,can also lead to serious body injures.Therefore,it is required and necessary to the treatment of patients with VVS.The treatment of VVS includes health education,drug treatment and non-drug treatment.

Tachycardia induced cardiomyopathy is a kind of cardiomyopathy caused by sustained or recurrent tachycardia.Various types of tachyarrhythmias can cause TIC, and the main clinical manifestations of it are cardiac dilatation and cardiac dysfunction.TIC can occur at all ages and is a reversible and acquired cardiomyopathy with a generally benign prognosis.After early diagnosis and reasonable treatment to relive the tachycardia, the function of the heart can partially or completely recover.In clinical practice, pediatricians do not fully understand the disease, as a result, it is easily missed, misdiagnosed, then the proper diagnosis and treatment will be delayed.This article provides a systematic overview of the pathogenesis, clinical characteristics, diagnosis, differential diagnosis, treatment and prognosis of TIC in children, and aims to provide a basis for clinical pediatricians to recognize it early and treat it promptly.

Kawasaki disease shock syndrome (KDSS)is a critical state of Kawasaki disease(KD)characterized by peripheral circulatory perfusion disorder and hypotension.The main causes of shock include cytokine imbalance, myocardial dysfunction and vasculitis with continuous capillary leakage.Compared with KD, KDSS shows longer fever duration, more severe inflammatory reaction, more obvious increase of D-dimer level, higher incidence of cardiovascular system abnormalities and multiple organ dysfunction, and higher proportion of unresponsive IVIG and glucocorticoid use.The early clinical manifestations and laboratory examination results of KDSS are not typical, so it is difficult to make an earlier diagnosis.The therapy of KDSS mainly includes anti-shock therapy and anti-inflammatory therapy may be associated with faster remission of shock and inflammation and better improvement of long-term prognosis.Many factors are related to the occurrence and development of KDSS.

ObjectiveTo compare children's resilience and peer relationship in divorced and complete family,and explore the moderating effect of psychological resilience between family structure and peer relationship.Methods208 children from divorced family and 465 children from complete family were surveyed.Results(1)There were significant differences in children's resilience(divorced family (3.58±0.73),complete family(3.83±0.59),t=-2.765,P=0.006) and peer relationship(divorced family (3.47±0.72),complete family(3.73±0.59),t=-2.069,P=0.042) between complete and divorced family.(2) Family structure had remarkable negative correlation with resilience and peer relationship(r1=-0.19,r2=-0.20),and resilience had positive correlation with peer relationship(r=0.43).(3)The moderating effect of resilience between family structure and peer relationship was significant(β=0.641,P<0.05).ConclusionParent divorce has negative influence on children's resilience and peer relationship.Furthermore,the relationship of family structure and peer relationship is mediated by resilience.The negative influence of parent divorce on peer relationship is not significant among children with high resilience,while it is significant on children with low resilience.

Lung cancer is the leading cause of cancer death worldwide. Significant advancements have been observed in the thera-py for non-small celllung cancer (NSCLC). With constant extension of new awareness regarding the histopathology of lung cancer, ho-mologous chemotherapeutic regimens have been developed on the basis of histopathological sub-typing methods. With developments in molecular biology, driving gene mutations during tumorigenesis and progression have been discovered. A series of targeted drugs for various molecular subtypes has also been investigated and developed on the basis of these mutations. This review summarizes recently published clinical outcomes on the management of advanced NSCLC and strategies to apply drugs in clinical treatments.

Objective:To analyze data of 5604 cases who received health examination in our hospital ,and understand morbidities of overweight and obesity in these people and their relationship with blood glucose level . Methods :Morning venous blood was taken from the 5604 subjects undergoing health examination to measure blood glucose lev‐el ,and their body weight and height were measured at the same time ,then body mass index (BMI) was calculated and analyzed .Results:Among the 5604 subjects , prevalence rates of overweight and obesity were 42.1% and 13. 3% respectively ,and they were 50% and 16. 4% in men ,and 25. 4% and 6. 8% in women respectively .Among different age groups (except ≥71 years group) , prevalence rate of overweight in men was significantly higher than that of women , P<0.01 all;except ≥61 years subjects , prevalence rate of obesity in men was significantly higher than that of women ,P<0.01 .In overweight group ,risk relative (RR) of impaired fasting blood glucose and dia‐betes mellitus to those of subjects with normal body weight was 2.32 (95% CI 1.91~2.82) and 2.92 (95% CI 2.31~3.70) respectively ;in obesity group , RR of impaired fasting blood glucose and diabetes mellitus to those of subjects with normal body weight was 3.2 (95% CI 2.57~3.99) and 5.17 (95% CI 4.53~5.90) respectively , P=0.001 all . Conclusion:Overweight and obesity have become a common problem among our customer groups .Compared with those with normal body weight ,overweight and obesity greatly increase risk ratio of impaired fasting blood glucose .

Holter monitoring remains an useful diagnostic tool in the evaluation of syncope in children if synco-pe remains unexplained after the initial examination.But it should not be used as a screening tool.Holter monitoring is recommended in children who were suspected as cardiac syncope or who had an abnormal electrocardiogram.For chil-dren with frequent syncope,Holter monitoring is highly recommended.More information can be provided with extended Holter monitoring to 48 hours if possible.Heart rate variability is probably useful in predicting head -up tilt test diagno-sis of neurally mediated syncope.