Incisional hernia is open a major postoperative complication that abdominal surgery remains. The incision type, suture technique, and the choice of primary suture materials are the main factors affecting wound healing. Prophylactic subfascial non-absorbable mesh can be used in high-risk patients to prevent in-cisional hernia.

Intermedin can promote tumor angiogenesis through a variety of signaling pathways. Hypoxia of tumor cells can induce an increased expression of intermedin. Recently, there have been a surge of researches on the relation between intermedin and tumor initiation, progression and metastasis. Intermedin may be a new target for tumor therapy.

Acquired resistance of EGFR-TKIs has become the major limitation of the efficacy of targeted therapy for lung cancer. Lung cancer has been treated by traditional Chinese medicine (TCM) combined with EGFR-TKIs, which originated from clinic. In recent years, reversing research has been conducted based on clinic application to discuss TCM intervening, improving and reversing EGFR-TKIs acquired resistance becoming a novel target for research. This article reviewed mechanism and effects of TCM herbs and compounds’ with the efficacy of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis strengthening the body resistance, and invigorating the circulation of blood, and proposed that the whole regulation and targeted therapy of TCM may carry out synergistic effect and become innovation treatment model for lung cancer.

Objective To explore the correlation between anemia and the pathogenesis and prognosis of patients with lung cancer. Methods From January 2013 to December 2014, 257 patients with primary lung cancer who were firstly treated at the First Affiliated Hospital of Anhui Medical University were retrospectively analyzed. The clinical data of the patients were collected and the patients were divided into anemia group and control group. The relationship of gender, age, and pathogenesis with anemia was analyzed by x 2 test. Survival analysis was evaluated by Kaplan-Meier and Log-rank test. Results The TNM stage, lymph nodes and remote metastasis , and ECOG score between the two groups were statistically different (x 2 values were 7.94, 4.97, 4.69, 9.02, all P< 0.05). The survival of the two groups showed statistical differences (x2=7.02, P=0.008). Conclusion Anemia might be correlated with the stage, lymph nodes and remote metastasis, ECOG score and prognosis of patients with lung cancer.

Endothelin-1 (ET-1) was characterized as a powerful vasoconstrictor and mitogen for smooth muscle. ET-1 binds to two types of receptors: ET_ A-R and ET_ B-R. Pulmonary arterial hypertension (PH) is a severe condition characterized by a progressive increase in pulmonary vascular resistance. The Endothelial dysfunction plays an important role in the development of pulmonary arterial hypertension. PH can be treated by antagonism of ET-1.

Objective:To evaluate therapeutic effect and safety of Firebird stent combined tirofiban on acute myocar‐dial infarction (AMI) .Methods :A total of 86 AMI patients treated in our hospital from Aug 2011 to Aug 2013 were selected .According to random number table method ,patients were divided into combined treatment group (n=50 , received Firebird stenting combined tirofiban treatment ) and routine treatment group (n=36 ,received bare metal stenting) .Patients were followed up for 12~18 months ,therapeutic effects ,incidence rates of clinical events were compared between two groups .Results:After PCI ,compared with routine treatment group ,there were significant reductions in percentage of TIMI class 1~2 (13.9% vs .4.0% ) and corrected TIMI frame [ (29.2 ± 4.4) vs .(21.4 ± 5.1)] ,significant rise in percentage of TIMI class 3~4 (86.1% vs .96.0% ) in combined treatment group , P<0.05 all;on six months after PCI ,compared with routine treatment group ,there were significant reductions in inci‐dence rates of subacute thrombosis (2.8% vs .0% ) and myocardial infarction (2.8% vs . 0% ) in combined treat‐ment group (P<0.05 both);on 12 months after operation ,compared with routine treatment group ,there were sig‐nificant reductions in incidence rates of angina pectoris (16.7% vs .6.0% ) ,subacute thrombosis rate (11.1% vs . 0% ) ,myocardial infarction (8.3% vs .0% ) ,heart failure (2.8% vs .0% ) and rehospitalization rate (11.1% vs . 0% ) in combined treatment group , P<0.05 or <0.01 .Conclusion:Firebird stent combined tirofiban possesses sig‐nificant therapeutic effect on acute myocardial infarction ,and it's safe and reliable ,which is worth extending .

Objective To study the effects of cyclooxygenase( COX)?2 selective inhibitors on post?endoscopic retrograde cholangiopancreatography ( ERCP ) pancreatitis ( PEP ) and hyperamylasemia for common bile duct stones. Methods A total of 128 patients with normal serum amylase underwent ERCP from June 2014 to February 2015 in our hospital and were given corresponding drugs to prevent PEP.The pa?tients were divided randomly into four groups:combination group( n=33) , celecoxib group( n=34) , nitro?glycerin group(n=32) and control group(n=29). The serum amylase(AMS), C?reactive protein(CRP) and direct bilirubin( Dbil) after ERCP were measured. Abdominal pain was observed, and the incidence of PEP and post?ERCP hyperamylasemia were recorded. Results The incidence of PEP in combination group, celecoxib group were lower than those in nitroglycerin group and the control group ( 3?03%, 2?94% VS 15?63%, 17?24%),but the difference was not statistically significant(P=0?078).The incidence of post?ERCP hyperamylasemia in combination group and celecoxib group were lower than that in the control group ( 3?03%,5?88% VS 31?03%) with statistically significant difference( P=0?003, P=0?010) . There was no significant difference between nitroglycerin group ( 25%) and control group. The abdominal pain grades of combination group and celecoxib group were lower than those in nitroglycerin group and control group with significant difference(P<0?05). Celecoxib may reduce CRP after ERCP(P=0?001) and nitroglycerin may reduce Dbil after ERCP(P=0?016). Conclusion Celecoxib may reduce the incidence of hyperamylasemia and can help to reduce the abdominal pain and inflammatory reactions after ERCP . Nitroglycerin can help to reduce the Dbil after ERCP .

Exosome is a sort of vesicle structure attached to cell membrane and released by cells, which contains numerous bioactive molecules, such as proteins, lipids, mRNA, microRNA and DNA fragments. These bioactive molecules are involved in the regulation of many biological processes, not only the participation in the occurrence and development of diverse diseases, but also the close relationship with the invasion and metastasis of tumors. The recent study has indicated that lots of exosomes released from cancer cells participate in a variety of pathological processes as a messenger of cell functions. This article will elaborate the function and application of exosomes in some malignant cancers.

Objective Mapping the sites of earliest activation in AF patients with rheumatic heart disease. Finding out the ratio of AF originate from the pulmonary veins. Methods There were 9 patients with valvular atrial fibrillation (1 male, 8 females age (42?13) years, histories of rheumatic heart disease (11?9) years, and mitral valve area 1.01?0.02 cm2) involved in the research. 3 patients had organized thrombus in left atrial appendage. 6 patients with persistent AF received anticoagulation therapy (warfarin 2 or 3 weeks) and drug cardioversion (amiodarone 400 mg, three times per day, for 7 days) before procedures, while other 3 patients with paroxysmal AF received neither anticoagulation therapy nor drug cardioversion. All patients received percutaneous balloon mitral valvotomy (PBMV). After finished PBMV, four multipolar electrode catheters were placed in the high right atrium (HRA), coronary sinus (CS), left atrium (LA) and pulmonary veins (PVs). S1S2 and S1S2S3 programmed stimuli were delivered in HRA, CS, LA and PVs respectively. For the patients who failed to induce AF, burst stimuli were used. Results 11 AF generating sites, which induced by S1S2 and S1S2S3 programmed stimuli, could be confirmed by identification of the earliest regions of atrial activation for the first AF cycle. However, 1 AF obtained by 260 ms RR interval burst stimuli, affirmed by shortest activation cycle length. All confirmed 12 AF original sites were original as following: RA (n=4), LA (n=1), CS (n=2); PVs (n=5). Among the 5 PVs original sites, 3 was from left superior pulmonary vein, while the other 2 were from right superior pulmonary vein and left inferior pulmonary respectively. Conclusion PVs could be the ectopic origin of valvular AF.

AIM: To separate and determine berberine type alkaloids in Huanglian Shangqing Pills(tablets)(Rhizoma Coptidis,Fructus Gardeniae,Fructus Forsythiae,Cortex Phellodendri Chinensis,etc.). METHODS: RP-HPLC was used,and the mobile phase consisted of acetonitrile-solution of potassium phosphate(3.4 g?L~(-1),adjust pH to 3.0 with H_3PO_4)(40∶60),with 1.7 g?L~(-1) SDS.The detecting wavelength was at 345 nm. RESULTS: The contents of five kinds of berberine type alkaloids,berberine,palmatine,coptisine,epiberberine and jatrorrhizine in Huanglian Shangqing Pills(tablets) produced by 10 pharmaceutical factories were determined. CONCLUSION: The method is simple,accurate with a good recovery and repeatability.The method can be used to control the quality of Huanglian Shangqing Pills(Tablets).