Objectives: To explore and summarize the beneficial effects of a traditional Chinese medicine prepara-tion, Tripterygium glycosides tablets (TGT), in rheumatoid arthritis (RA) animal models of neo-vascularization, and to provide a reference for future clinical applications and research on its pharmacologic mechanism.Methods: We searched the databases PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, VIP, Wan Fang and SinoMed (China Biomedical Document Service System) to identify studies of TGT with outcome indicators of angiogenesis-related factors that were published before April 2020. Subgroup analysis and meta-regression were performed for dosage and duration of TGT. Statistical tests and subgroup analysis were conducted using RevMan 5.3, and meta-regression and sensitivity analysis were conducted using STATA/SE 15.0. Results: Fourteen studies of TGT in RA rats were included in this analysis. Treatment with TGT signifi-cantly reduces synovial microvessel density and the expression of vascular endothelial growth factor (VEGF), VEGF receptor 2, hypoxia inducible factor α, c-Fos, c-Jun, angiopoietin-1 and angiopoietin-2 compared with control groups (P < .05). Subgroup analysis did not show a significant association of the mRNA levels of VEGF in synovium, assessed using quantitative real-time PCR, with duration or dosage of TGT. Meta-regression analysis also indicated that the effects of dosage and duration were not significantly associated with differences in VEGF mRNA levels. Sensitivity analysis on VEGF mRNA levels did not fundamentally change the results. Conclusions: TGT can reduce synovial neovascularization by decreasing synovial microvessel density and expression of VEGF, VEGF receptor 2, hypoxia-inducible factorα, c-Fos, c-Jun, Ang-1 and Ang-2, thereby suppressing pannus formation and bone destruction in rat models of RA. Additional well-designed studies are required to confirm these findings.

Objective? To explore the disinfection effects of Cavi wipes and chlorine containing disinfectant on object surface touched frequently among multidrug resistance infection patients in intensive care unit. Methods? We selected 40 multidrug resistance infection patients with mechanical ventilation in general intensive care unit (GICU) and respiratory intensive care unit (RICU) at Liangxiang Hospital in Fangshan District from June 2016 to May 2018 by convenience sampling. All of the patients were randomly divided into control group (object surface disinfection by 500 mg/L chlorine containing disinfectant) and experimental group (object surface disinfection by Cavi wipes). We carried out sampling and bacterial culture in object surface touched by patients frequently both groups (right bed handrail, ventilator panel parameter key and infusion pump on/off key) before, 5 minutes, 6 hours and 8 hours after disinfection and monitored the target drug-resistance bacteria. Results? Before disinfection, there were no statistical differences in the bacterial culture results of object surface touched frequently in patients between two groups (P＞ 0.05). After disinfection, the bacterial colony counting of object surface touched frequently in patients between two groups was lower than that before with statistical differences (P＜0.01). The colony counting 8 hours after disinfection of experimental group were lower than those of control group with statistical differences (P＜0.05). Conclusions? Cavi wipes and 500 mg/L chlorine containing disinfectant all have good disinfection effects. Disinfection effects of Cavi wipes in bed and other object surface touched frequently are better than those of chlorine containing disinfectant which is convenient and is worthy of being widely used in clinical application.

AIM:To observe the clinical effect of ciliary sulcus suture fixation of intraocular lens(IOL)with the scleral tunnel technique.METHODS: The clinical data of 36 patients(38 eyes)who underwent ciliary sulcus suture fixation of IOL with the scleral tunnel technique in our hospital from May 2021 to September 2023 were retrospectively analyzed. The patients were followed up for a total of 3-26 mo. The postoperative IOL position, visual acuity, refraction, intraocular pressure and complications were observed, and the results of tear film break-up time(BUT), corneal fluorescein staining(FL)and Schirmer Ⅰ test(SⅠt )were evaluated.RESULTS: The uncorrected visual acuity and best corrected visual acuity of all eyes were improved at 3 mo after surgery(all P<0.01). The differences of BUT and FL score before operation, and at 1 and 3 mo after operation were statistically significant(all P<0.05). Postoperative slit lamp examination showed the IOL of all eyes remained well positioned, and no suture erosion was observed.CONCLUSION: Ciliary sulcus suture fixation of IOL with the scleral tunnel technique is a safe, efficient, and minimally invasive procedure.