Objective To deeply investigate the psychosocial factors affecting Chinese nurse occupational burnout.Methods An online literature search was carried out in China National Knowledge Infrastructure,VIP Database for Chinese Technical Periodicals and Wanfang database to collect relevant articles.CMA2.0 was used to analyze the fifty literatures which satisfied the uniform inclusion and exclusion criteria.Results (1)On emotional exhaustion and depersonalization,passive coping styles had moderate positive effect,neuroticism had high positive effect,work stress had low positive effect; active coping styles,self-efficiency,social support and extroversion had low negative effect.Psychotics and lying had positive or negative moderate effect on depersonalization respectively.(2)On personal accomplishment,self-efficiency had high positive effect,active coping styles,lying and subjective support had moderate positive effect,neuroticism,psychotics and work stress had small negative effect,passive coping styles had no effect.(3)Self-esteem had no significant relationship with occupational burnout.Conclusions Nurse's occupational burnout resulted from psychosocial factors,including coping style,self-efficiency,personality,social support and work stress.

Objective:Comparative analysis detection indexes such as [ inhibition C ( CysC ) , BUN, Scr, eGFR-MDRD and eGFR-cys] of application value in the diagnosis of early DN.Methods: Randomly collected the Type 2 diabetes ( Type 2 diabetes mellitus,T2DM)214 cases patients to our hospital check-up and 100 healthy people from January 2012 to October 2014,and according to the urinary albumin excretion rate could divided into pure T2DM group and diabetes group(DN group),collected the patient′s serum creatinine( Scr) ,urea nitrogen( BUN) ,serum[ inhibition( Cys C) detection indexes such as C,and USES the simplified MDRD formula according to the Scr estimate the eGFR(eGFR-MDRD),while using CysC CHINAcys equation calculated eGFR,eGFR-Cys],make statistical analysis for these measurements.Results: DN group compared with control group ,the BUN,Scr,CysC,eGFR-MDRD and eGFR-cys had significant changes,including BUN,Scr and CysC was significantly higher than control group;EGFR-MDRD and eGFR-cys significantly lower compared with control group,5 testing indexes,P<0.05.Five commonly used detection index curve of ROS area was greater than 0.5,and P<0.05.A single detection index of CysC indicators could reach 80.38,the highest followed by BUN and eGFR-MDRD;And joint detection of eGFR MDRD+Cys C much higher sensitivity and an index of eGFR-MDRD+eGFR-Cys and other individual detection index.Conclusion:eGFR-MDRD CysC indicator in the diagnosis of early DN screening is an effective,feasible, and the method of high accuracy.

Heart rate variability (HRV) is an important point to judge a person's state in modern medicine. This paper is aimed to research a person's fatigue level connected with vagal nerve based on the HRV using the improved Welch method. The process of this method is that it firstly uses a time window function on the signal to be processed, then sets the length of time according to the requirement, and finally makes frequency domain analysis. Compared with classical periodogram method, the variance and consistency of the present method have been improved. We can set time span freely using this method (at present, the time of international standard to measure HRV is 5 minutes). This paper analyses the HRV's characteristics of fatigue crowd based on the database provided by Physio-Net. We therefore draw the conclusion that the accuracy of Welch analyzing HRV combining with appropriate window function has been improved enormously, and when the person changes to fatigue, the vagal activity is diminished and sympathetic activity is raised.
Fatigue ; diagnosis ; Heart Rate ; Humans ; Regression Analysis

A new method was developed for the determination of 11 fat_soluble vitamins ( A, D, E and K) and its derivatives in vitamin tablets by ultra performance convergence chromatography ( UPC2 ) . The mobile phase was the mixture of supercritical CO2 and acetonitrile at a flow rate of 1 mL/min. The separation was carried out on the Waters Acquity UPC2 HSS C18 SB 100 mm × 3. 0 mm i. d. , 1. 8 μm column. The UV detector was set at a wavelength of 284 nm. The limits of detection ( LOD) were 1. 5-2. 0 mg/L, and the calibration linear for VK1 , VK2 , VK3 and VB3 was 3-300 mg/L, linear for VA, VA palmitate, VA formic acid, VE, VE acetate, VD2 and VD3 was 5-300 mg/L, respectively. Its spiked recoveries were 97. 31%-98. 76%, and the relative standard deviations ( RSDs) were 0. 41%-0. 96%. The method is applicable for the determination of fat_soluble vitamins ( A, D, E and K) and Their derivatives in vitamin tablets.

Objective To explore the corresponding relationship between isolated Q waves in lead Ⅲ on the electrocardiography(ECG) and echocardiographie segmental diagnosis of myocardial infarction(MI).Methods The shape magnitude of Q waves of 27 patients with MI and the relationship with eehocardiographie features were investigated. Results Twenty-four patients with inferior wall myocardial infarction had close relationship with isolated Q waves in lead Ⅲ on the ECG. Conclusions There is definite corresponding relation between isolated Q waves in lead Ⅲ and inferior wall myocardial infarction.

Objective To compare the difference of prospective memory(PM) between schizophrenia patients and normal people,and to analyze the internal component of prospective memory using multinomial processing tree(MPT) model.Methods 17 schizophrenia patients and 17 age-and education-matched control participants completed an event-based PM task which was embedded within an ongoing computer-based color-matching task.Internal component of prospective memory was analyzed using multinomial processing tree(MPT) model.Results The scores of prospective memory performance in schizophrenia patients and normal controls were (21.83± 2.46) ％ and (38.81±2.26) ％, and the difference was statistically significant (t=2.11, P＜0.05).The difference of ongoing task between schizophrenia patients ((75.88±0.43) ％) and controls ((71.44±0.45) ％) was statistically significant (t=2.79, P＜0.05).The reaction time of schizophrenia patients was significantly longer than that of normal controls((2.34±1.41) s vs (1.81± 1.19) s, t=11.24, P＜ 0.05).The MPT model revealed a significant group difference in the prospective component (0.82 vs 0.97, G2(1)=14.17, P＜ 0.01) and retrospective component (0.54 vs 0.41 ,G2(1) 14.17, P＜0.01).Conclusion The prospective component of event-based prospective memory of schizophrenia patients was lower than normal controls,which may result in the impairment of PM performance.

This article is dedicated to present a comprehensive review on the latest progress and future trends in developing detection methods of CTCs and cancer biomarkers. The article especially analyzes the methods to isolate, quantify and detect cancer cells via their distinctively different physical properties. The advantages and disadvantages of different detection approaches are also evaluated. The target towards cancer early detection was discussed. The important direction for developing comprehensive multi-mode detection method was emphasized.
Biomarkers, Tumor ; Early Detection of Cancer ; methods ; Humans ; Neoplasms ; diagnosis ; Neoplastic Cells, Circulating

OBJECTIVE:To explore the method for the scientific and standard management of clinical trial drugs. METHODS:By theory analysis and empirical analysis,the management model of clinical trial drugs in our hospital was introduced in terms of software and hardware construction of clinical trial pharmacy,the formulation of drug management system and standard operation procedure,regular quality control and drug information management platform construction,etc. RESULTS:In the experience of our hospital,it could safeguard the safety of drug use in subjects and scientificity and preciseness of drug clinical trial results through the concentrated administration trial drugs by full-time pharmacists according to national laws and regulations,management system and standard operation procedure,and regular quality control inspection by quality control group. CONCLUSIONS:Drug clinical trial institute strictly abide the requirements of Good Clinical Practice,strengthen the management of trial drugs and im-prove information management continuously,which is of important significance to construct standardized,detailed and high-effi-ciency centralized management system of clinical trial drugs.

Objective To evaluate the role of 11C-methionine positron emission tomographv(MET PET-CT)in differentiating tumor recurrence from radiation necrosis in brain slioma patients.Methods From June 2008 to September 2009,30 brain glioma patients with suspected tumor recurvence or radiation necrosis after radiotherapy were evaluated by MET PET-CT.The median time between initial radiotherapy and PET examination was 13.5 months.Tumor recurrence were confirmed by histological analysis while necrosis was based on histological analysis or the subsequent clinical follow-up.Results Eighteen out of 19 patients were histologically confirmed tumor recurrence among those tumor recurrence shown by MET PET-CT after surgery or stereotactic biopsy.11 patients were considered to have radiation necrosis because of stable neurological sympotoms and without massive enlargement of the lesion during the after follow-up.The sensitivity,specificity and accuracy of MET PET-CT for detecting tumor recurrence were 100%,91.7%and 96.7%respectively.Conclusion MET PET-CT is a powerful tool in differentiating brain tumor recurrence from radiation necrosis after radiotherapy.

Object To explore the antitumor mechanism of Stellera chamaejasme Linn.(SC).Methods SC containing-serum(SCCS)was derived from mice pretreated with different doses of SC.Cultured human leukemia HL-60 and human gastric adenocarcinoma SGC-7901 cells were used.Inhibition of proliferation was measured using MTT assay.Morphological assessment of apoptosis was performed with fluorescence microscope.DNA fragmentation was assessed by agarose gel electrophoresis and flow cytometry.Expression of bcl-2 protein was measured with immunohistochemistry.Results Exposure of exponentially growing HL-60 cells to mice serum containing 10% SC(pretreated with SC3,6, and 12 g/kg)for 48h resulted in growth inhibition in a dose-dependent manner.Typical morphological changes of apoptosis and DNA fragmentation in HL-60 cells were induced."Apobodies'in the apoptotic cells were observed,'ladder"pattern of agarose gel electrophoresis of DNA from 11.7% to 57.4%.Treatment with SC containing serum decreased the percentage of SGC-7901 cell of bcl-2 protein positive expression from 78.3% to 32.9%.Conclusion SC could induce apoptosis of HL-60 cells and decrease the expression of bcl-2 protein of gastric adenocarcinoma SGC-7901 cells.