Objective To explore the effect of integrated traditional Chinese medicine ( TCM) and western medicine on prognosis and quality of life of dysphagia in patients with stroke after surgery. Methods A total of 80 patients who underwent surgical treatment for stroke in our hospital were evaluated by GUSS, and 48 patients were found having dysphagia and were randomly divided into the control group and the observation group. Patients in the control group was given routine nursing, while the observation group was given integrated TCM and western medicine nursing combined with routine nursing. The complication rates, SDS and SAS scores were compared between two groups.Results The complication rates in the observation group was 8.3 %, and was 29.2% in the control group (χ2=4.25, P<0.05); the rehabilitation rate was 70.8% in the observation group and was 50.0% in the control group (χ2=4.18, P<0.05). After nursing intervention, scores of SAS and SDS in the observation group were significantly lower than the control group (t=4.45, 5.01;P<0.05). Conclusions Integrative TCM and western medicine nursing can effectively improve patients′ prognosis, decrease complication rates, alleviate negative emotion and improve quality of life.