No abstract available.
Listeriosis*

No abstract available.
Child* ; Humans ; Listeria monocytogenes ; Listeria* ; Listeriosis* ; Meningitis ; Sepsis

No abstract available.
Animals ; Listeria* ; Listeriosis* ; Mice*

Listeriosis in a healthy child is extremely rare. A previously healthy 9-year-old male was admitted with pyrexia, headache and lethargy. The CSF cultures, taken on admission and on the 5th day, showed growth of Listeria monocytogenes. L. monocytogenes was identified by various methods, including polymerase chain reaction(PCR). Serologically, it showed type 1/2a. However, blood cultures, which were taken on the same days, revealed no growth of L. monocytogenes. Ceftriaxone and amikacin had no effect on the progress of the disease. The combination of ampicillin plus gentamicin, which is regarded as the treatment of choice for L. monocytogenes infection, had an effect in this case. Patient showed severe neurological symptoms and signs, such as diplopia, esotropia, nystagmus, ptosis and other meningeal signs during the hospital days, even though all such symptoms and signs were improved at discharge. We report the case with brief review of related literatures.
Amikacin ; Ampicillin ; Ceftriaxone ; Child* ; Diplopia ; Esotropia ; Fever ; Gentamicins ; Headache ; Humans ; Lethargy ; Listeria monocytogenes ; Listeria* ; Listeriosis ; Male ; Meningitis, Listeria*

Since it has been named as Listeria monocytogenes after its detection in 20th century, listeriosis has been known as a microorganism to parasitize and proliferate in cytoplasm of eucaryotic cell in many researches. As listeriosis has been occurred frequently in malignancy, leukemia, alcoholism, pregnant women, neonates and patients who has been administered immunosuppressants, a declined cell- mediated immune system of these patients has gotten the clinical attention as a common pattern. Infections by listeria have been rarely reported in end stage renal disease patients with a reduction in cell- medicated immune system. Through our experience, we'd like to report a meningitis by Listeria monocytogenes which has not been submitted in Korea yet.
Alcoholism ; Cytoplasm ; Female ; Humans ; Immune System ; Immunosuppressive Agents ; Infant, Newborn ; Kidney Failure, Chronic ; Korea ; Leukemia ; Listeria monocytogenes* ; Listeria* ; Listeriosis ; Meningitis ; Meningitis, Listeria* ; Pregnant Women ; Renal Dialysis*

Listeria monocytogenes (L. monocytogenes) is a foodborne anaerobic gram-positive rod and the third most common pathogen for neonatal meningitis. Although the mortality and morbidity of L. monocytogenes infections are high, thus causing serious problems in Western populations, neonatal listeriosis is relatively rare in Eastern countries, including Korea. Possible routes for intrauterine infection or vertical transmission of L. monocytogenes include infected placentas and the reproductive tract. Intrauterine infections may cause chorioamnionitis, preterm labor, spontaneous abortion, stillbirth, or neonatal infection. A high index of suspicion and early empirical antibiotic treatment are critical to achieve a favorable prognosis for neonatal listeriosis. We managed a case of L. monocytogenes sepsis and pneumonia in a premature neonate born at 26 weeks of gestational age from an asymptomatic mother with culture-proven placental infection. The neonate was successively treated with ampicillin and gentamicin.
Abortion, Spontaneous ; Ampicillin ; Chorioamnionitis ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Korea ; Listeria ; Listeria monocytogenes ; Listeriosis ; Meningitis ; Mothers ; Obstetric Labor, Premature ; Placenta ; Pneumonia ; Pregnancy ; Prognosis ; Sepsis ; Stillbirth

Listeria monocytogenes is a facultative anaerobic, gram-positive bacillus that is isolated from the soil, vegetables, and wild or domestic animals. Listeria occurs predominantly in the elderly, immunocompromised patients, pregnant women and newborns. Infections by this microorganism are rare in healthy infants and children. L. monocytogenes may cause meningitis, meningoencephalitis, brain abscess, pyogenic arthritis, osteomyelitis, and liver abscesses in children. The course of meningoencephalitis by listeria is often severe and even fatal. Acute hydrocephalus can develop as a complication and the mortality associated with listeriosis is significantly high. We present a case of meningoencephalitis caused by L. monocytogenes in a previously healthy 7-year-old girl.
Aged ; Animals, Domestic ; Arthritis ; Bacillus ; Brain Abscess ; Child ; Female ; Humans ; Hydrocephalus ; Immunocompromised Host ; Infant ; Infant, Newborn ; Listeria ; Listeria monocytogenes ; Listeriosis ; Liver Abscess ; Meningitis ; Meningoencephalitis ; Osteomyelitis ; Pregnant Women ; Soil ; Vegetables

BACKGROUND: Listeria monocytogenes is a foodborne oppotunistic pathogen causing meningoencephalitis and bacteremia in certain groups such as neonates, pregnant women, the elderly, or immunosuppressed patients. We investigated the predisposing conditions, and laboratory and clinical features for listeriosis of non-pregnant adult patients in tertiary care hospitals. METHODS: Sixteen patients diagnosed at AMC from 1997 to April 2002 were newly analyzed. In addition, 20 cases published in domestic literatures from 1973 to 1997 were retrospectively reviewed for their medical records or literatures to evaluate demographic, clinical, and laboratory data. RESULTS: While AMC cases comprised 14 bacteremia, 2 meningitis, and 1 peritonitis, literature cases comprised 17 meningitis, 2 bacteremia, and 1 endocarditis. All but one endocarditis patients were in immunocompromised states such as malignancy (19 patients), diabetes (7), transplantation (5), SLE, asthma with steroid therapy (4), elderly alcoholics (1), and elderly tuberculosis (1). Ten of 36 cases developed fever 5 days after admission. All but two strains were susceptible to penicillin or ampicillin, and 28 of 29 treated cases received beta-lactam agents. Fifteen patients (41.6%), including 11 patients with malignancy, expired. Blood cultures were positive in all 19 meningitis cases, but direct smears of CSF for bacteria were positive in only 20%. CONCLUSION: L. monocytogenes frequently caused life-threatening sepsis or meningitis in immunocompromised patients at a tertiary care hospitaL. For early diagnosis of L. monocytogenesis infection, microbiology laboratories are advised to improve the sensitivity of CSF smear.
Adult* ; Aged ; Alcoholics ; Ampicillin ; Asthma ; Bacteremia ; Bacteria ; Early Diagnosis ; Endocarditis ; Female ; Fever ; Humans ; Immunocompromised Host ; Infant, Newborn ; Korea* ; Listeria monocytogenes* ; Listeria* ; Listeriosis ; Medical Records ; Meningitis ; Meningoencephalitis ; Penicillins ; Peritonitis ; Pregnant Women ; Retrospective Studies ; Sepsis ; Tertiary Healthcare ; Tuberculosis

Listeria monocytogenes has been recognized as a pathogen in elderly and immunecompromised hosts with malignancies, alcohol abuse, diabetes mellitus, transplanted organs, liver cirrhosis, renal failure, or acquired immunodeficiency syndrome (AIDS). In adults, it usually presents as neuromeningeal infection, such as meningitis, meningoencephalitis, or encephalitis, or as primary bacteremia. Involvement of the liver with L. monocytogenes is uncommon. We report on a case of multiple liver abscesses and bacteremia associated with L. monocytogenes in a 67-year-old diabetic female with concomitant active multidrug-resistant pulmonary tuberculosis. Blood cultures were positive for L. monocytogenes. In patients with liver abscess with advanced age or who are immune-compromised, including those with diabetes, clinicians should consider Listeria infection as a differential diagnosis.
Acquired Immunodeficiency Syndrome ; Adult ; Aged ; Alcoholism ; Bacteremia ; Diabetes Mellitus ; Diagnosis, Differential ; Encephalitis ; Female ; Humans ; Listeria ; Listeria monocytogenes ; Listeriosis ; Liver ; Liver Abscess ; Liver Cirrhosis ; Meningitis ; Meningoencephalitis ; Renal Insufficiency ; Transplants ; Tuberculosis, Pulmonary

BACKGROUND: Listeria monocytogenes is a foodborne oppotunistic pathogen causing meningoencephalitis and bacteremia in certain groups such as neonates, pregnant women, the elderly, or immunosuppressed patients. We investigated the predisposing conditions, and laboratory and clinical features for listeriosis of non-pregnant adult patients in tertiary care hospitals. METHODS: Sixteen patients diagnosed at AMC from 1997 to April 2002 were newly analyzed. In addition, 20 cases published in domestic literatures from 1973 to 1997 were retrospectively reviewed for their medical records or literatures to evaluate demographic, clinical, and laboratory data. RESULTS: While AMC cases comprised 14 bacteremia, 2 meningitis, and 1 peritonitis, literature cases comprised 17 meningitis, 2 bacteremia, and 1 endocarditis. All but one endocarditis patients were in immunocompromised states such as malignancy (19 patients), diabetes (7), transplantation (5), SLE, asthma with steroid therapy (4), elderly alcoholics (1), and elderly tuberculosis (1). Ten of 36 cases developed fever 5 days after admission. All but two strains were susceptible to penicillin or ampicillin, and 28 of 29 treated cases received beta-lactam agents. Fifteen patients (41.6%), including 11 patients with malignancy, expired. Blood cultures were positive in all 19 meningitis cases, but direct smears of CSF for bacteria were positive in only 20%. CONCLUSION: L. monocytogenes frequently caused life-threatening sepsis or meningitis in immunocompromised patients at a tertiary care hospitaL. For early diagnosis of L. monocytogenesis infection, microbiology laboratories are advised to improve the sensitivity of CSF smear.
Adult* ; Aged ; Alcoholics ; Ampicillin ; Asthma ; Bacteremia ; Bacteria ; Early Diagnosis ; Endocarditis ; Female ; Fever ; Humans ; Immunocompromised Host ; Infant, Newborn ; Korea* ; Listeria monocytogenes* ; Listeria* ; Listeriosis ; Medical Records ; Meningitis ; Meningoencephalitis ; Penicillins ; Peritonitis ; Pregnant Women ; Retrospective Studies ; Sepsis ; Tertiary Healthcare ; Tuberculosis