Objective To evaluate the effect of high-level spinal cord injury (SCI) on the myocardial energy metabolism in rats.Methods Sixty healthy male Sprague-Dawley rats,weighing 250-300 g,were randomly divided into 2 groups (n=30 each) using a random number table:sham operation (group S) and SCI group.SCI was induced in anesthetized rats by dropping a 10 g weight onto C7 spinal cord from 5 cm height falling freely inside a vertical hollow glass tube.At 6,12,24,48 and 72 h after SCI,6 rats in each group were chosen and arterial blood samples were taken for measurement of serum creatine kinase (CK) and creatine kinase isoenzyme-MB (CK-MB) activities.The rats were then sacrificed and myocardial specimens were obtained for examination of myocardial ultrastructure and for determination of ATP weight ratio,levels of Na+-K+-ATPase,Ca2+-Mg2+-ATPase,non-esterified fatty acids (NEFA) and lactic acid (LD),and expression of peroxisome proliferator-activated receptor alpha (PPARα) mRNA and protein (using fluorescent quantitative PCR and Western blot).Results Compared with group S,the serum CK and CK-MB activities were significantly increased,the ATP weight ratio,activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase and levels of NEFA and LD were decreased,and the expression of PPAR-α mRNA and protein was down-regulated in SCI group.No pathological changes of myocardium were found in group S,and the pathological changes of myocardium were obvious in SCI group.Conclusion High-level SCI can lead to decrease in the myocardial energy metabolism in rats,and down-regulated expression of PPARα is involved in the mechanism.

Objective To analyze the current status,hotspots and difficulties of research on colo-rectal serrated polyps using CiteSpace software.Methods Chinese literature was searched in the Chi-na National Knowledge Infrastructure(CNKI)database from its inception to March 6,2023.English literature was searched in the Medline database from its inception to March 21,2023.CiteSpace soft-ware was used to create visual maps and conduct visual analysis of publication volume,institutions and keywords.Results A total of 198 Chinese articles were included in this study,with Beijing Military General Hospital publishing the most articles."Pathology"appeared with the highest frequency,and clinic and endoscopic characteristics had been research hotspots in recent years.This study included 1257 English articles.The keyword"colorectal cancer"appeared with the highest frequency,adenoma detection,colon cancer screening,computer-aided detection,adenoma missed diagnosis rate and arti-ficial intelligence had been research hotspots in recent years.Conclusion The research interest in colorectal serrated polyps is gradually increasing both domestically and internationally,with research hotspots focusing on adenoma detection,colon cancer screening,computer-aided detection,adenoma missed diagnosis rate,and artificial intelligence.

Objective To analyze the current status,hotspots and difficulties of research on colo-rectal serrated polyps using CiteSpace software.Methods Chinese literature was searched in the Chi-na National Knowledge Infrastructure(CNKI)database from its inception to March 6,2023.English literature was searched in the Medline database from its inception to March 21,2023.CiteSpace soft-ware was used to create visual maps and conduct visual analysis of publication volume,institutions and keywords.Results A total of 198 Chinese articles were included in this study,with Beijing Military General Hospital publishing the most articles."Pathology"appeared with the highest frequency,and clinic and endoscopic characteristics had been research hotspots in recent years.This study included 1257 English articles.The keyword"colorectal cancer"appeared with the highest frequency,adenoma detection,colon cancer screening,computer-aided detection,adenoma missed diagnosis rate and arti-ficial intelligence had been research hotspots in recent years.Conclusion The research interest in colorectal serrated polyps is gradually increasing both domestically and internationally,with research hotspots focusing on adenoma detection,colon cancer screening,computer-aided detection,adenoma missed diagnosis rate,and artificial intelligence.