Ethical issues have been the kind of problems that we have to face in medical research.The article,from the perspective of ethical problems in medical research,on the basis of analyzing the reasons and harms of the problem,puts forward the following strategies,such as,strengthen ethical consciousness of the medical scientific research personnel,reinforce ethical responsibility of the medical scientific research personnel,play the role of supervision by the ethical review,improve the scientific management system and system construction.In order to realize the medical purpose,we must put heart and soul into for the people the mental and physical health services.

As an important subject of higher medical education,medical ethics has its unique theoretical system and teaching pattern of education and teaching.A scientific planning of the teaching content of medical ethics is a key component in improving teaching effect,promoting students' moral,intellectual,physical and aesthetical development for being high quality medical talents,and better realizing the teaching target of medical ethics.

Scientific design of the teaching content of medical ethics is a crucial element in achieving satisfying educational effect of medical ethics,making it more consistent with the developing tendency of diversity in majors and arrangement of medical colleges,better solving the conflict between the limitations of teaching time span and the diversity of teaching content,promoting teaching effects,and contributing the all-round development of medical students.

With the rapid development of modern medicine,the particularity of medical and health industry becomes more and more prominent.It has increased the public' strong appeal about medical works' reverencing life.On the ethical implication of reverencing life as the breakthrough point,the article elaborated the basic contents of medical students'ethical education about reverencing life,and strive to explore a multi-channel,three-dimensional,all-round education path.

BACKGROUND:There are many experimental studies about compression mechanics of femur after hip replacement at home and aboard. Therefore, it is very important to study the torque, torsion angle, load-displacement relationship of femur after hip replacement. Comparing and analyzing the properties of compression and torsional mechanics of traditional-type prosthesis and anatomical-type prosthesis is of important significance for studying hip replacement and the stability of artificial prosthesis.
OBJECTIVE:To compare and analyze the stability of traditional-type prosthesis and anatomical-type prosthesis by stimulating femoral axial compression and torsion tests after hip replacement, so as to provide biomechanical parameters for clinic practice.
METHODS: Twelve specimens of left- and/or right-side femur were selected. The femoral necks of 6 left-side femur specimens were retained as the anatomical-type titanium artificial joint prosthesis group, and the femoral necks of the 6 right-side femur specimens were removed as the traditional-type cobalt-chromium-molybdenum artificial joint prosthesis group. The femur specimens in these two groups were respectively placed onto the electronic universal testing machine workbench and were imposed compression stress at the experimental velocity of 5 mm/min. The corresponding displacement values were read under the force of 20, 40, 60, 80 and 100 N. And then, both ends of the femur specimens from these two groups were placed within the chuck of torsion testing machine, and were imposed torque at the experimental velocity of 1(°)/s. The corresponding torsion angle values were read under the torque force of 5, 10, 15 and 20 N?m.
RESULTS AND CONCLUSION: Under the external force of 100 N, the displacement was (2.03±0.06) mm in the traditional-type prosthesis group, and (1.83±0.05) mm in the anatomical-type prosthesis group. Under the torque force of 20 N?m, the torsion angle values of traditional-type prosthesis was (21.7±0.7)°, and that of anatomical-type prosthesis was (13.2±0.4)°. The displacement under the external force of 100 N and the torsion angle values under the torque force of 20 N?m in the anatomical-type prosthesis group were al significantly less than those in the traditional-type prosthesis group (P < 0.05). These results suggest that traditional-type and anatomical-type prostheses have different compression and torsion mechanical properties. The anatomical-type femur prosthesis has a better stability than traditional-type femur prosthesis.

Objective To investigate the effect of suppression of ischemia induced retinal neovascularization by VEGF antisense oligodeoxyribonucleotides. [WT5”HZ]Methods [WT5”BZ]Mouse models of hyperoxia induced ischemic retinopathy were established. Retrobulbar injections were performed with VEGF antisense oligodeoxyribonucleotides or NS in 4 groups:normal control and various doses respectively. The nuclei of new vessel buds extending from the retina into the vitreous in different groups were counted and compared under the light microscope. Results There were plenty of new vessel buds in the eyes of mice in hyperoxic condition., while the number of the nuclei of new vessel buds is less in the murine eyes with retrobulbar injection of VEGF antisense oligodeoxyribonucleotides,especially the nuclei were redused with 59.3% in eyes with large dose. Conclusion The proliferation of retinal new vessel may be suppressed by using the retrobulbar injection of VEGF antisense oligodeoxyribonucleotides.

CD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily and is involved in various physiological and pathological activities.Highly expressed on the surface of many tumor cells,CD147 can promote tumor metastasis,angiogenesis and anchorage-independent growth.Targeting CD147 in cancer appears a promising therapeutic strategy.This review outlines the recent findings concerning the role of CD147 in tumor progression.

Objective Discuss the methodology and significance of clinical transfusion assessment,establish an effective evaluation system for blood transfusion,identify rational indexes for the evaluation,and promote quality of clinical transfusion.Methods Development of the clinical blood transfusion assessment regulations,tightened blood transfusion approval system,enhanced medical record check for blood transfusion,better statistics for the data collected,and analysis of data in 2012 to compare changes in blood volume before and after tighter management in place.These efforts aim at improving the assessment system for optimal clinical blood transfusion.Results Compared to Jan.-June in 2012,patients discharged and surgical cases in Dec.of the same year dropped 2.15％ and 0.73％ respectively.However,the volume of blood transfusion decreased 22.7％,the percentage of blood transfusion for inpatients decreased from 8.78％ to 7.17％,and the average use of blood for inpatients decreased from 0.73U to 0.57U.Conclusion Reasonable and scientific assessment for blood transfusion and better clinical blood use management can improve blood transfusion therapeutic efficacy and save blood resources.

Objective To investigate the change of surface molecules and cytokine expressions of dendritic cells (DC) stimulated with recombinant proteins Com1 and heat shock protein B (HspB) of Coxiella burnetii (Cb).MethodsThe DC cultured for 5 d were stimulated with 20 μg/mL recombinant protein Com1,20μg/mL HspB or 6 μg/mL E.coli lipopolysaccharide (LPS).Twentyfour hours later,the surface mature marker,CD83,and activation-associated markers of T lymphocytes,CD58,CD54,CD40,CD80 and CD86,and expression levels of interleukin (IL)-10 and IL-12 of DC were detected by fluorescence activated cell sorter (FACS).Multiple comparisons were performed by using Student-Newman-Keuls test.ResultsCom1 could induce DC maturation efficiently in vitro.Human monocyte-derived DC exhibited significantly higher expression levels of surface molecules including CD83,CD54,CD58,CD80,CD86,and CD40,which were all ＞80％.CD83 expression induced by Com1 was similar with that induced by 1E.coli LPS,while CD54 and CD86 expressions were slightly higher than those induced by E.coli LPS,and expressions of other molecules were significantly higher than those induced by E.coli LPS (all P＜0.05).After Com1 stimulation,intracellular IL-12 level increased to 9 ％ from zero.HspB could not induce DC maturation in vitro.The intracellular IL-10 level was 6％ after HspB stimulation.DC pulsed with Com1 and HspB exhibited intracellular IL-12 level of zero and IL-10 level of ＜2％.Conclusion Com1 but not HspB can efficiently activate DC and Com1-activated DC can drive T cells toward Th1 cell development due to a high level of IL-12 production.

A cross-sectional study was performed among 5134 health check-up subjects in Tianjin Municipality.Compared with control group [ (274 ± 76)μmol/L],patients with non-alcoholic fatty liver disease (NAFLD) had a higher level of serum uric acid[ (340 ± 81 )μmol/L]. Moreover,in NAFLD patients,along with the increase of the severity of fatty liver from mild,intermediate to severe,the serum levels of uric acid increased from (331 ±78),(347 ± 83) to (377 ±75 ) μmol/L ( F =19.68,P ＜0.01 ).Regression analysis found that sex(β=-0.43 ),serum triglyceride(β =0.53 ),fasting plasma glucose(β =-0.21 )and BMI(β =0.19) were associated with uric acid level in NAFLD patients; but insulin level and homeostasis model of assessment-insulin resistance were not associated with uric acid level. The results indicate that serum uric acid levels may be used as a biomarker for the severity of NAFLD.